Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy

Detalhes bibliográficos
Autor(a) principal: Cruz, Alda Maria da
Data de Publicação: 1999
Outros Autores: Figueiras, Danilo V., Coutinho, Ziadir, Mayrink, Wilson, Grimaldi Jr., Gabriel, Luca, Paula M. de, Mendonça, Sergio C. F., Coutinho, Sergio G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02761999000400020
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44024
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Humoral. Rio de Janeiro, RJ, Brasil.
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spelling Cruz, Alda Maria daFigueiras, Danilo V.Coutinho, ZiadirMayrink, WilsonGrimaldi Jr., GabrielLuca, Paula M. deMendonça, Sergio C. F.Coutinho, Sergio G.2020-10-16T20:30:07Z2020-10-16T20:30:07Z1999CRUZ, Alda M. da et al. Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 4, p. 537-542, July/Aug. 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/4402410.1590/S0074-027619990004000201678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmaniose mucocutânea humanaSíndrome da Imunodeficiência AdquiridaCélulas CD8 +Interferon-γImunoterapiaHuman mucocutaneous leishmaniasisAcquired immunodeficiency syndromeCD8+ cellsInterferon-γImmunotherapyAtypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Humoral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée-Guinle. Serviço de Dermatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée-Guinle. Serviço de Dermatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.An atypical case of acquired immunodeficiency syndrome-associated mucocutaneous lesions due to Leishmania braziliensis is described. Many vacuolated macrophages laden with amastigote forms of the parasite were found in the lesions. Leishmanin skin test and serology for leishmaniasis were both negative. The patient was resistant to therapy with conventional drugs (antimonial and amphotericin B). Interestingly, remission of lesions was achieved after an alternative combined therapy of antimonial associated with immunotherapy (whole promastigote antigens). Peripheral blood mononuclear cells were separated and stimulated in vitro with Leishmania antigens to test the lymphoproliferative responses (LPR). Before the combined immunochemotherapy, the LPR to leishmanial antigens was negligible (stimulation index - SI=1.4). After the first course of combined therapy it became positive (SI=4.17). The antigen responding cells were predominantly T-cells (47.5%) most of them with CD8+ phenotype (33%). Very low CD4+ cells (2.2%) percentages were detected. The increased T-cell responsiveness to leishmanial antigens after combined therapy was accompanied by interferon-γ (IFN-γ) production as observed in the cell culture supernatants. In this patient, healing of the leishmaniasis lesions was associated with the induction of a specific T-cell immune response, characterized by the production of IFN-γ and the predominance of the CD8+ phenotype among the Leishmania-reactive T-cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44024/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGabrielGJunor_SergioCoutinho_etal_IOC_1999.pdfGabrielGJunor_SergioCoutinho_etal_IOC_1999.pdfapplication/pdf34997https://www.arca.fiocruz.br/bitstream/icict/44024/2/GabrielGJunor_SergioCoutinho_etal_IOC_1999.pdf048a484422f3045037ffe5e683c8980eMD52TEXTGabrielGJunor_SergioCoutinho_etal_IOC_1999.pdf.txtGabrielGJunor_SergioCoutinho_etal_IOC_1999.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
title Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
spellingShingle Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
Cruz, Alda Maria da
Leishmaniose mucocutânea humana
Síndrome da Imunodeficiência Adquirida
Células CD8 +
Interferon-γ
Imunoterapia
Human mucocutaneous leishmaniasis
Acquired immunodeficiency syndrome
CD8+ cells
Interferon-γ
Immunotherapy
title_short Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
title_full Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
title_fullStr Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
title_full_unstemmed Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
title_sort Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
author Cruz, Alda Maria da
author_facet Cruz, Alda Maria da
Figueiras, Danilo V.
Coutinho, Ziadir
Mayrink, Wilson
Grimaldi Jr., Gabriel
Luca, Paula M. de
Mendonça, Sergio C. F.
Coutinho, Sergio G.
author_role author
author2 Figueiras, Danilo V.
Coutinho, Ziadir
Mayrink, Wilson
Grimaldi Jr., Gabriel
Luca, Paula M. de
Mendonça, Sergio C. F.
Coutinho, Sergio G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Alda Maria da
Figueiras, Danilo V.
Coutinho, Ziadir
Mayrink, Wilson
Grimaldi Jr., Gabriel
Luca, Paula M. de
Mendonça, Sergio C. F.
Coutinho, Sergio G.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose mucocutânea humana
Síndrome da Imunodeficiência Adquirida
Células CD8 +
Interferon-γ
Imunoterapia
topic Leishmaniose mucocutânea humana
Síndrome da Imunodeficiência Adquirida
Células CD8 +
Interferon-γ
Imunoterapia
Human mucocutaneous leishmaniasis
Acquired immunodeficiency syndrome
CD8+ cells
Interferon-γ
Immunotherapy
dc.subject.en.pt_BR.fl_str_mv Human mucocutaneous leishmaniasis
Acquired immunodeficiency syndrome
CD8+ cells
Interferon-γ
Immunotherapy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunidade Celular e Humoral. Rio de Janeiro, RJ, Brasil.
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2020-10-16T20:30:07Z
dc.date.available.fl_str_mv 2020-10-16T20:30:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Alda M. da et al. Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 4, p. 537-542, July/Aug. 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44024
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761999000400020
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CRUZ, Alda M. da et al. Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 4, p. 537-542, July/Aug. 1999.
0074-0276
10.1590/S0074-02761999000400020
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44024
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language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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