ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection

Detalhes bibliográficos
Autor(a) principal: Torres, Lauana Ribas
Data de Publicação: 2022
Outros Autores: Capobianco, Lyana Rodrigues Pinto Lima, Souza, Audrien Alves Andrade de, Ribeiro, Camilla Rodrigues de Almeida, Cascabulho, Cynthia, Garzoni, Luciana Ribeiro, Portari, Elyzabeth Avvad, Gardel, Marcelo Aranha, Batista, Marcelo Meuser, Paula, Vanessa Salete de, Souza, Elen Mello de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.virol.2022.03.004
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54949
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Torres, Lauana RibasCapobianco, Lyana Rodrigues Pinto LimaSouza, Audrien Alves Andrade deRibeiro, Camilla Rodrigues de AlmeidaCascabulho, CynthiaGarzoni, Luciana RibeiroPortari, Elyzabeth AvvadGardel, Marcelo AranhaBatista, Marcelo MeuserPaula, Vanessa Salete deSouza, Elen Mello de2022-09-30T18:40:48Z2022-09-30T18:40:48Z2022TORRES, Lauana Ribas et al. ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection. Virology, v. 570, p. 45 - 56, 2022.0042-6822https://www.arca.fiocruz.br/handle/icict/5494910.1016/j.virol.2022.03.004engElsevierZIKVBRCoinfecçãoSuscetibilidade placentáriaCitocinaTransmissão congênitaHV-2BRZIKVBRHHV-2BRCoinfectionPlacental susceptibilityCytokineCongenital transmissionHHV-2BRZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat´orio de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborat´orio de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Coordenação Diagnóstica de Anatomia Patológica e Citopatologia.Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil.During the Zika fever outbreak in Brazil in 2015–2016, only some babies from infected mothers had teratogenic effects, suggesting that cofactors may influence congenital transmission. We investigated the ZIKV infection profile in explants and isolated cells from full-term human placenta to infection with the Brazilian Zika virus strain (ZIKVBR) and the effect of coinfection with the Brazilian Human alphaherpesvirus 2 strain (HSV-2BR) on ZIKV replication. We found that the ZIKVBR infect the explants of amniotic and chorionic membranes, as well as chorionic villi core, but not the trophoblasts layer. It was also observed that ZIKV replication was higher in amniotic cells than chorionic and trophoblasts cells. Upon coinfection, the replication of ZIKVBR was reduced according to exposed HSV-2BR load in trophoblasts cells and the levels of TNF-α and IL-6 cytokines were also reduced. These findings suggest that the placental cell types and HSV-2BR coinfection may impact on ZIKV replication.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVanessaSaletePaula_LauanaRTTorres_etal_IOC_2022.pdfVanessaSaletePaula_LauanaRTTorres_etal_IOC_2022.pdfapplication/pdf7616840https://www.arca.fiocruz.br/bitstream/icict/54949/2/VanessaSaletePaula_LauanaRTTorres_etal_IOC_2022.pdfe56d873fb4b0951fdb96a25087511825MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54949/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/549492023-09-04 11:17:46.401oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:17:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
title ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
spellingShingle ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
Torres, Lauana Ribas
ZIKVBR
Coinfecção
Suscetibilidade placentária
Citocina
Transmissão congênita
HV-2BR
ZIKVBR
HHV-2BR
Coinfection
Placental susceptibility
Cytokine
Congenital transmission
HHV-2BR
title_short ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
title_full ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
title_fullStr ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
title_full_unstemmed ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
title_sort ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection
author Torres, Lauana Ribas
author_facet Torres, Lauana Ribas
Capobianco, Lyana Rodrigues Pinto Lima
Souza, Audrien Alves Andrade de
Ribeiro, Camilla Rodrigues de Almeida
Cascabulho, Cynthia
Garzoni, Luciana Ribeiro
Portari, Elyzabeth Avvad
Gardel, Marcelo Aranha
Batista, Marcelo Meuser
Paula, Vanessa Salete de
Souza, Elen Mello de
author_role author
author2 Capobianco, Lyana Rodrigues Pinto Lima
Souza, Audrien Alves Andrade de
Ribeiro, Camilla Rodrigues de Almeida
Cascabulho, Cynthia
Garzoni, Luciana Ribeiro
Portari, Elyzabeth Avvad
Gardel, Marcelo Aranha
Batista, Marcelo Meuser
Paula, Vanessa Salete de
Souza, Elen Mello de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Torres, Lauana Ribas
Capobianco, Lyana Rodrigues Pinto Lima
Souza, Audrien Alves Andrade de
Ribeiro, Camilla Rodrigues de Almeida
Cascabulho, Cynthia
Garzoni, Luciana Ribeiro
Portari, Elyzabeth Avvad
Gardel, Marcelo Aranha
Batista, Marcelo Meuser
Paula, Vanessa Salete de
Souza, Elen Mello de
dc.subject.other.en_US.fl_str_mv ZIKVBR
Coinfecção
Suscetibilidade placentária
Citocina
Transmissão congênita
HV-2BR
topic ZIKVBR
Coinfecção
Suscetibilidade placentária
Citocina
Transmissão congênita
HV-2BR
ZIKVBR
HHV-2BR
Coinfection
Placental susceptibility
Cytokine
Congenital transmission
HHV-2BR
dc.subject.en.en_US.fl_str_mv ZIKVBR
HHV-2BR
Coinfection
Placental susceptibility
Cytokine
Congenital transmission
HHV-2BR
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-30T18:40:48Z
dc.date.available.fl_str_mv 2022-09-30T18:40:48Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TORRES, Lauana Ribas et al. ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection. Virology, v. 570, p. 45 - 56, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54949
dc.identifier.issn.en_US.fl_str_mv 0042-6822
dc.identifier.doi.none.fl_str_mv 10.1016/j.virol.2022.03.004
identifier_str_mv TORRES, Lauana Ribas et al. ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection. Virology, v. 570, p. 45 - 56, 2022.
0042-6822
10.1016/j.virol.2022.03.004
url https://www.arca.fiocruz.br/handle/icict/54949
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54949/2/VanessaSaletePaula_LauanaRTTorres_etal_IOC_2022.pdf
https://www.arca.fiocruz.br/bitstream/icict/54949/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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