Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23448 |
Resumo: | Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brazil. |
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Ribeiro, Edlene LimaBarbosa, Karla Patricia de SouzaFragoso, Ingrid TavaresDonato, Mariana Aragão MatosGomes, Fabiana Oliveira dos SantosSilva, Bruna Santos daSoares e Silva, Amanda KarolinaRocha, Sura Wanessa SantosSilva Junior, Valdemiro Amaro daPeixoto, Christina Alves2017-11-29T12:18:36Z2017-11-29T12:18:36Z2014RIBEIRO, E. L. et al. Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. Mediators of Inflammation, v. 2014, p. 105120, 2014.1466-1861https://www.arca.fiocruz.br/handle/icict/2344810.1155/2014/105120engDECAnti-InflamatóriosLesão PulmonarDECAnti-Inflammatory AgentsLung InjuryCarrageninaefeitos adversosDietilcarbamazinaquímicaRegulação da Expressão Gênicaefeitos de drogasLesão Pulmonarinduzido quimicamenteLesão Pulmonartratamento farmacológicoAdministração OralAnimaisAnti-InflamatóriosquímicaCiclo-Oxigenase 2metabolismoInflamaçãoMasculinoInterleucina-1betametabolismoLeucócitosefeitos de drogasInibidores de LipoxigenasequímicaCamundongosÓxido Nítrico Sintase Tipo IIPleurisiainduzido quimicamenteDistribuição AleatóriaDiethylcarbamazine attenuates the development of carrageenan-induced lung injury in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil.Universidade Federal Rural de Pernambuco. Departamento de Morfologia e Fisiologia Animal. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratorio de Ultraestrutura. Recife, PE, Brazil.Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-α and increased expression of interleukin-1β, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-κB. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23448/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. Diethylcarbamazine Attenuates - ribeiro.pdfart. Diethylcarbamazine Attenuates - ribeiro.pdfapplication/pdf6007802https://www.arca.fiocruz.br/bitstream/icict/23448/2/art.%20Diethylcarbamazine%20Attenuates%20-%20ribeiro.pdfac1b6700ec4b292331a13203cb3744f4MD52TEXTart. Diethylcarbamazine Attenuates - ribeiro.pdf.txtart. 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| dc.title.pt_BR.fl_str_mv |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| title |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| spellingShingle |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice Ribeiro, Edlene Lima DEC Anti-Inflamatórios Lesão Pulmonar DEC Anti-Inflammatory Agents Lung Injury Carragenina efeitos adversos Dietilcarbamazina química Regulação da Expressão Gênica efeitos de drogas Lesão Pulmonar induzido quimicamente Lesão Pulmonar tratamento farmacológico Administração Oral Animais Anti-Inflamatórios química Ciclo-Oxigenase 2 metabolismo Inflamação Masculino Interleucina-1beta metabolismo Leucócitos efeitos de drogas Inibidores de Lipoxigenase química Camundongos Óxido Nítrico Sintase Tipo II Pleurisia induzido quimicamente Distribuição Aleatória |
| title_short |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| title_full |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| title_fullStr |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| title_full_unstemmed |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| title_sort |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| author |
Ribeiro, Edlene Lima |
| author_facet |
Ribeiro, Edlene Lima Barbosa, Karla Patricia de Souza Fragoso, Ingrid Tavares Donato, Mariana Aragão Matos Gomes, Fabiana Oliveira dos Santos Silva, Bruna Santos da Soares e Silva, Amanda Karolina Rocha, Sura Wanessa Santos Silva Junior, Valdemiro Amaro da Peixoto, Christina Alves |
| author_role |
author |
| author2 |
Barbosa, Karla Patricia de Souza Fragoso, Ingrid Tavares Donato, Mariana Aragão Matos Gomes, Fabiana Oliveira dos Santos Silva, Bruna Santos da Soares e Silva, Amanda Karolina Rocha, Sura Wanessa Santos Silva Junior, Valdemiro Amaro da Peixoto, Christina Alves |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ribeiro, Edlene Lima Barbosa, Karla Patricia de Souza Fragoso, Ingrid Tavares Donato, Mariana Aragão Matos Gomes, Fabiana Oliveira dos Santos Silva, Bruna Santos da Soares e Silva, Amanda Karolina Rocha, Sura Wanessa Santos Silva Junior, Valdemiro Amaro da Peixoto, Christina Alves |
| dc.subject.other.pt_BR.fl_str_mv |
DEC Anti-Inflamatórios Lesão Pulmonar |
| topic |
DEC Anti-Inflamatórios Lesão Pulmonar DEC Anti-Inflammatory Agents Lung Injury Carragenina efeitos adversos Dietilcarbamazina química Regulação da Expressão Gênica efeitos de drogas Lesão Pulmonar induzido quimicamente Lesão Pulmonar tratamento farmacológico Administração Oral Animais Anti-Inflamatórios química Ciclo-Oxigenase 2 metabolismo Inflamação Masculino Interleucina-1beta metabolismo Leucócitos efeitos de drogas Inibidores de Lipoxigenase química Camundongos Óxido Nítrico Sintase Tipo II Pleurisia induzido quimicamente Distribuição Aleatória |
| dc.subject.en.pt_BR.fl_str_mv |
DEC Anti-Inflammatory Agents Lung Injury |
| dc.subject.decs.pt_BR.fl_str_mv |
Carragenina efeitos adversos Dietilcarbamazina química Regulação da Expressão Gênica efeitos de drogas Lesão Pulmonar induzido quimicamente Lesão Pulmonar tratamento farmacológico Administração Oral Animais Anti-Inflamatórios química Ciclo-Oxigenase 2 metabolismo Inflamação Masculino Interleucina-1beta metabolismo Leucócitos efeitos de drogas Inibidores de Lipoxigenase química Camundongos Óxido Nítrico Sintase Tipo II Pleurisia induzido quimicamente Distribuição Aleatória |
| description |
Universidade Federal de Pernambuco. Pós-Graduação em Ciências Biológicas. Recife, PE, Brazil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brazil. |
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2014 |
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2014 |
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2017-11-29T12:18:36Z |
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2017-11-29T12:18:36Z |
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RIBEIRO, E. L. et al. Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. Mediators of Inflammation, v. 2014, p. 105120, 2014. |
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1466-1861 |
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10.1155/2014/105120 |
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RIBEIRO, E. L. et al. Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. Mediators of Inflammation, v. 2014, p. 105120, 2014. 1466-1861 10.1155/2014/105120 |
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