Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint)
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44945 |
Resumo: | Hongchao Pan (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Richard Peto (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Ana-Maria Henao-Restrepo (World Health Organization. Geneva, Switzerland); Marie-Pierre Preziosi (World Health Organization. Geneva, Switzerland); Vasee Sathiyamoorthy (World Health Organization. Geneva, Switzerland); Quarraisha Abdool Karim (Centre for the AIDS Programme of Research in South Africa. Durban, South Africa); Marissa M. Alejandria (University of the Philippines. National Institutes of Health. Institute of National Epidemiology. Manila, Philippines); César Hernández García (Spanish Agency of Medicines and Medical Devices. Madrid, Spain / Hospital Clínico San Carlos. Madrid, Spain); Marie-Paule Kieny (Institut National de la Santé et de la Recherche Médicale. Paris, France); Reza Malekzadeh (Tehran University of Medical Sciences. Digestive Disease Research Institute. Tehran, Iran); Srinivas Murthy (University of British Columbia. Vancouver, Canada); K. Srinath Reddy (Public Health Foundation of India. New Delhi, India); Mirta Roses Periago (National Academy of Sciences of Buenos Aires. Buenos Aires, Argentina); Pierre Abi Hanna (Rafic Hariri University Hospital. Beirut, Lebanon); Florence Ader (Hospices Civils de Lyon. Lyon, France); Abdullah M. Al-Bader (Ministry of Health. Kuwait City, Kuwait); Almonther Alhasawi (Infectious Diseases Hospital. Kuwait City, Kuwait); Emma Allum (University of Bristol. Bristol, United Kingdom); Athari Alotaibi (Ministry for Preventive Health. Riyadh, Saudi Arabia); Carlos A. Alvarez-Moreno (Universidad Nacional de Colombia. Bogotá, Colombia / Clinica Colsanitas. Bogotá, Colombia); Sheila Appadoo (University of Bern. Bern, Switzerland); Abdullah Asiri (Ministry for Preventive Health. Riyadh, Saudi Arabia); Pål Aukrust (Oslo University Hospital. Oslo, Norway); Andreas Barratt-Due (Oslo University Hospital. Oslo, Norway); Samir Bellani (University of Bristol. Bristol, United Kingdom); Mattia Branca (University of Bern. Bern, Switzerland); Heike B.C. Cappel-Porter (University of Bristol. Bristol, United Kingdom); Nery Cerrato (Secretaria de Salud de Honduras. Tegucigalpa, Honduras); Ting S. Chow (Penang Hospital. Penang, Malaysia); Najada Como (University Hospital Center "Mother Teresa". Tirana, Albania); Joe Eustace (University College Cork. HRB Clinical Research Facility. Cork, Ireland); Patricia J. García (Universidad Peruana Cayetano Heredia. Lima, Peru); Sheela Godbole (Indian Council of Medical Research. New Delhi, India / National AIDS Research Institute. Pune, Maharashtra, India); Eduardo Gotuzzo (Universidad Peruana Cayetano Heredia. Lima, Peru); Laimonas Griskevicius (Vilnius University Hospital Santaros Klinikos. Vilnius, Lithuania); Rasha Hamra (Ministry of Public Health. Beirut, Lebanon); Mariam Hassan (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Mohamed Hassany (National Hepatology and Tropical Medicine Research Institute. Cairo, Egypt); David Hutton (University of Bristol. Bristol, United Kingdom); Irmansyah Irmansyah (National Institute of Health Research and Development. Jakarta, Indonesia); Ligita Jancoriene (Vilnius University. Faculty of Medicine. Institute of Clinical Medicine. Vilnius, Lithuania); Jana Kirwan (University of Bristol. Bristol, United Kingdom); Suresh Kumar (Sungai Buloh Hospital. Selangor, Malaysia / Jalan Hospital. Selangor, Malaysia); Peter Lennon (Department of Health and Children. Dublin, Ireland); Gustavo Lopardo (Fundación del Centro de Estudios Infectológicos. Buenos Aires, Argentina); Patrick Lydon (World Health Organization. Geneva, Switzerland); Nicola Magrini (Italian Medicines Agency. Rome, Italy); Teresa Maguire (Department of Health and Children. Dublin, Ireland); Suzana Manevska (Ministry of Health. Skopje, North Macedonia); Oriol Manuel (Lausanne University Hospital. Lausanne, Switzerland); Sibylle McGinty (University of Bern. Bern, Switzerland); Marco T. Medina (Universidad Nacional Autónoma de Honduras. Tegucigalpa, Honduras); María L. Mesa Rubio (Ministry of Health. Bogotá, Colombia); Maria C. Miranda-Montoya (World Health Organization. Geneva, Switzerland); Jeremy Nel (University of the Witwatersrand. Johannesburg, South Africa); Estevão Portela Nunes (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Markus Perola (National Institute for Health and Welfare of Finland. Helsinki, Finland / University of Finland. Helsinki, Finland); Antonio Portolés (Universidade Complutense de Madrid. Madrid, Spain / Spanish Clinical Research Network. Madrid, Spain / Hospital Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos. Madrid, Spain); Menaldi R. Rasmin (Rumah Sakit Umum Pusat Persahabatan. Jakarta, Indonesia); Aun Raza (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Helen Rees (Wits Reproductive Health and HIV Institute. Johannesburg, South Africa); Paula P. S. Reges (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Chris A. Rogers (University of Bristol. Bristol, United Kingdom); Kolawole Salami (World Health Organization. Geneva, Switzerland); Marina I. Salvadori (Public Health Agency of Canada. Ottawa, Canada); Narvina Sinani (National Agency for Medicines and Medical Devices. Tirana, Albania); Jonathan A. C. Sterne (University of Bristol. Bristol, United Kingdom); Milena Stevanovikj (University Clinic of Infectious Diseases and Febrile Conditions. Skopje, North Macedonia); Evelina Tacconelli (University of Verona. Verona, Italy); Kari A. O. Tikkinen (Helsinki University Hospital. Helsinki, Finland / South Karelian Central Hospital. Lappeenranta, Finland); Sven Trelle (University of Bern. Bern, Switzerland); Hala Zaid (Ministry of Health and Population. Cairo, Egypt); John-Arne Røttingen (Research Council of Norway. Oslo, Norway); Soumya Swaminathan (World Health Organization. Geneva, Switzerland). |
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Hongchao, PanPeto, RichardHenao-Restrepo, Ana-MariaPreziosi, Marie-PierreSathiyamoorthy, VaseeKarim, Quarraisha AbdoolAlejandria, Marissa M.Hernández García, CésarKieny, Marie-PauleMalekzadeh, RezaMurthy, SrinivasReddy, K. SrinathPeriago, Mirta RosesHanna, Pierre AbiAder, FlorenceAl-Bader, Abdullah M.Alhasawi, AlmontherAllum, EmmaAlotaibi, AthariAlvarez-Moreno, Carlos A.Appadoo, SheilaAsiri, AbdullahAukrust, PålBarratt-Due, AndreasBellani, SamirBranca, MattiaCappel-Porter, Heike B. C.Cerrato, NeryChow, Ting S.Como, NajadaEustace, JoeGarcía, Patricia J.Godbole, SheelaGotuzzo, EduardoGriskevicius, LaimonasHamra, RashaHassan, MariamHassany, MohamedHutton, DavidIrmansyah, IrmansyahJancoriene, LigitaKirwan, JanaKumar, SureshLennon, PeterLopardo, GustavoLydon, PatrickMagrini, NicolaMaguire, TeresaManevska, SuzanaManuel, OriolMcGinty, SibylleMedina, Marco T.Mesa Rubio, María L.Miranda-Montoya, Maria C.Nel, JeremyNunes, Estevão PortelaPerola, MarkusPortolés, AntonioRasmin, Menaldi R.Raza, AunRees, HelenReges, Paula P. S.Rogers, Chris A.Salami, KolawoleSalvadori, Marina I.Sinani, NarvinaSterne, Jonathan A. C.Stevanovikj, MilenaTacconelli, EvelinaTikkinen, Kari A. O.Trelle, SvenZaid, HalaRøttingen, John-ArneSwaminathan, Soumya2020-12-16T19:38:48Z2020-12-16T19:38:48Z2020HONGCHAO, Pan et al. Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (preprint). MedRxiv, p. 1-17, 15 Oct. 2020.https://www.arca.fiocruz.br/handle/icict/4494510.1101/2020.10.15.20209817Hongchao Pan (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Richard Peto (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Ana-Maria Henao-Restrepo (World Health Organization. Geneva, Switzerland); Marie-Pierre Preziosi (World Health Organization. Geneva, Switzerland); Vasee Sathiyamoorthy (World Health Organization. Geneva, Switzerland); Quarraisha Abdool Karim (Centre for the AIDS Programme of Research in South Africa. Durban, South Africa); Marissa M. Alejandria (University of the Philippines. National Institutes of Health. Institute of National Epidemiology. Manila, Philippines); César Hernández García (Spanish Agency of Medicines and Medical Devices. Madrid, Spain / Hospital Clínico San Carlos. Madrid, Spain); Marie-Paule Kieny (Institut National de la Santé et de la Recherche Médicale. Paris, France); Reza Malekzadeh (Tehran University of Medical Sciences. Digestive Disease Research Institute. Tehran, Iran); Srinivas Murthy (University of British Columbia. Vancouver, Canada); K. Srinath Reddy (Public Health Foundation of India. New Delhi, India); Mirta Roses Periago (National Academy of Sciences of Buenos Aires. Buenos Aires, Argentina); Pierre Abi Hanna (Rafic Hariri University Hospital. Beirut, Lebanon); Florence Ader (Hospices Civils de Lyon. Lyon, France); Abdullah M. Al-Bader (Ministry of Health. Kuwait City, Kuwait); Almonther Alhasawi (Infectious Diseases Hospital. Kuwait City, Kuwait); Emma Allum (University of Bristol. Bristol, United Kingdom); Athari Alotaibi (Ministry for Preventive Health. Riyadh, Saudi Arabia); Carlos A. Alvarez-Moreno (Universidad Nacional de Colombia. Bogotá, Colombia / Clinica Colsanitas. Bogotá, Colombia); Sheila Appadoo (University of Bern. Bern, Switzerland); Abdullah Asiri (Ministry for Preventive Health. Riyadh, Saudi Arabia); Pål Aukrust (Oslo University Hospital. Oslo, Norway); Andreas Barratt-Due (Oslo University Hospital. Oslo, Norway); Samir Bellani (University of Bristol. Bristol, United Kingdom); Mattia Branca (University of Bern. Bern, Switzerland); Heike B.C. Cappel-Porter (University of Bristol. Bristol, United Kingdom); Nery Cerrato (Secretaria de Salud de Honduras. Tegucigalpa, Honduras); Ting S. Chow (Penang Hospital. Penang, Malaysia); Najada Como (University Hospital Center "Mother Teresa". Tirana, Albania); Joe Eustace (University College Cork. HRB Clinical Research Facility. Cork, Ireland); Patricia J. García (Universidad Peruana Cayetano Heredia. Lima, Peru); Sheela Godbole (Indian Council of Medical Research. New Delhi, India / National AIDS Research Institute. Pune, Maharashtra, India); Eduardo Gotuzzo (Universidad Peruana Cayetano Heredia. Lima, Peru); Laimonas Griskevicius (Vilnius University Hospital Santaros Klinikos. Vilnius, Lithuania); Rasha Hamra (Ministry of Public Health. Beirut, Lebanon); Mariam Hassan (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Mohamed Hassany (National Hepatology and Tropical Medicine Research Institute. Cairo, Egypt); David Hutton (University of Bristol. Bristol, United Kingdom); Irmansyah Irmansyah (National Institute of Health Research and Development. Jakarta, Indonesia); Ligita Jancoriene (Vilnius University. Faculty of Medicine. Institute of Clinical Medicine. Vilnius, Lithuania); Jana Kirwan (University of Bristol. Bristol, United Kingdom); Suresh Kumar (Sungai Buloh Hospital. Selangor, Malaysia / Jalan Hospital. Selangor, Malaysia); Peter Lennon (Department of Health and Children. Dublin, Ireland); Gustavo Lopardo (Fundación del Centro de Estudios Infectológicos. Buenos Aires, Argentina); Patrick Lydon (World Health Organization. Geneva, Switzerland); Nicola Magrini (Italian Medicines Agency. Rome, Italy); Teresa Maguire (Department of Health and Children. Dublin, Ireland); Suzana Manevska (Ministry of Health. Skopje, North Macedonia); Oriol Manuel (Lausanne University Hospital. Lausanne, Switzerland); Sibylle McGinty (University of Bern. Bern, Switzerland); Marco T. Medina (Universidad Nacional Autónoma de Honduras. Tegucigalpa, Honduras); María L. Mesa Rubio (Ministry of Health. Bogotá, Colombia); Maria C. Miranda-Montoya (World Health Organization. Geneva, Switzerland); Jeremy Nel (University of the Witwatersrand. Johannesburg, South Africa); Estevão Portela Nunes (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Markus Perola (National Institute for Health and Welfare of Finland. Helsinki, Finland / University of Finland. Helsinki, Finland); Antonio Portolés (Universidade Complutense de Madrid. Madrid, Spain / Spanish Clinical Research Network. Madrid, Spain / Hospital Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos. Madrid, Spain); Menaldi R. Rasmin (Rumah Sakit Umum Pusat Persahabatan. Jakarta, Indonesia); Aun Raza (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Helen Rees (Wits Reproductive Health and HIV Institute. Johannesburg, South Africa); Paula P. S. Reges (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Chris A. Rogers (University of Bristol. Bristol, United Kingdom); Kolawole Salami (World Health Organization. Geneva, Switzerland); Marina I. Salvadori (Public Health Agency of Canada. Ottawa, Canada); Narvina Sinani (National Agency for Medicines and Medical Devices. Tirana, Albania); Jonathan A. C. Sterne (University of Bristol. Bristol, United Kingdom); Milena Stevanovikj (University Clinic of Infectious Diseases and Febrile Conditions. Skopje, North Macedonia); Evelina Tacconelli (University of Verona. Verona, Italy); Kari A. O. Tikkinen (Helsinki University Hospital. Helsinki, Finland / South Karelian Central Hospital. Lappeenranta, Finland); Sven Trelle (University of Bern. Bern, Switzerland); Hala Zaid (Ministry of Health and Population. Cairo, Egypt); John-Arne Røttingen (Research Council of Norway. Oslo, Norway); Soumya Swaminathan (World Health Organization. Geneva, Switzerland).Múltipla - ver em NotasBACKGROUND: WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS: Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a (mainly subcutaneous; initially with Lopinavir, later not). COVID-19 inpatients were randomized equally between whichever study drugs were locally available and open control (up to 5 options: 4 active and local standard-of-care). The intent-to-treat primary analyses are of in-hospital mortality in the 4 pairwise comparisons of each study drug vs its controls (concurrently allocated the same management without that drug, despite availability). Kaplan-Meier 28-day risks are unstratified; log-rank death rate ratios (RRs) are stratified for age and ventilation at entry. RESULTS: In 405 hospitals in 30 countries 11,266 adults were randomized, with 2750 allocated Remdesivir, 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon plus Lopinavir, 1412 only Interferon, and 4088 no study drug. Compliance was 94-96% midway through treatment, with 2-6% crossover. 1253 deaths were reported (at median day 8, IQR 4-14). Kaplan-Meier 28-day mortality was 12% (39% if already ventilated at randomization, 10% otherwise). Death rate ratios (with 95% CIs and numbers dead/randomized, each drug vs its control) were: Remdesivir RR=0.95 (0.81-1.11, p=0.50; 301/2743 active vs 303/2708 control), Hydroxychloroquine RR=1.19 (0.89-1.59, p=0.23; 104/947 vs 84/906), Lopinavir RR=1.00 (0.79-1.25, p=0.97; 148/1399 vs 146/1372) and Interferon RR=1.16 (0.96-1.39, p=0.11; 243/2050 vs 216/2050). No study drug definitely reduced mortality (in unventilated patients or any other subgroup of entry characteristics), initiation of ventilation or hospitalisation duration. CONCLUSIONS: These Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. The mortality findings contain most of the randomized evidence on Remdesivir and Interferon, and are consistent with meta-analyses of mortality in all major trials.engMedRxivhttps://www.arca.fiocruz.br/handle/icict/44967Drogas antivirais reutilizadasCOVID-19Organização Mundial da SaúdeOMSRe-purposed antiviral drugsCOVID-19World Health OrganizationWHORepurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNãoPublicadoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en.fl_str_mv |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
title |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
spellingShingle |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) Hongchao, Pan Drogas antivirais reutilizadas COVID-19 Organização Mundial da Saúde OMS Re-purposed antiviral drugs COVID-19 World Health Organization WHO |
title_short |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
title_full |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
title_fullStr |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
title_full_unstemmed |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
title_sort |
Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (Preprint) |
author |
Hongchao, Pan |
author_facet |
Hongchao, Pan Peto, Richard Henao-Restrepo, Ana-Maria Preziosi, Marie-Pierre Sathiyamoorthy, Vasee Karim, Quarraisha Abdool Alejandria, Marissa M. Hernández García, César Kieny, Marie-Paule Malekzadeh, Reza Murthy, Srinivas Reddy, K. Srinath Periago, Mirta Roses Hanna, Pierre Abi Ader, Florence Al-Bader, Abdullah M. Alhasawi, Almonther Allum, Emma Alotaibi, Athari Alvarez-Moreno, Carlos A. Appadoo, Sheila Asiri, Abdullah Aukrust, Pål Barratt-Due, Andreas Bellani, Samir Branca, Mattia Cappel-Porter, Heike B. C. Cerrato, Nery Chow, Ting S. Como, Najada Eustace, Joe García, Patricia J. Godbole, Sheela Gotuzzo, Eduardo Griskevicius, Laimonas Hamra, Rasha Hassan, Mariam Hassany, Mohamed Hutton, David Irmansyah, Irmansyah Jancoriene, Ligita Kirwan, Jana Kumar, Suresh Lennon, Peter Lopardo, Gustavo Lydon, Patrick Magrini, Nicola Maguire, Teresa Manevska, Suzana Manuel, Oriol McGinty, Sibylle Medina, Marco T. Mesa Rubio, María L. Miranda-Montoya, Maria C. Nel, Jeremy Nunes, Estevão Portela Perola, Markus Portolés, Antonio Rasmin, Menaldi R. Raza, Aun Rees, Helen Reges, Paula P. S. Rogers, Chris A. Salami, Kolawole Salvadori, Marina I. Sinani, Narvina Sterne, Jonathan A. C. Stevanovikj, Milena Tacconelli, Evelina Tikkinen, Kari A. O. Trelle, Sven Zaid, Hala Røttingen, John-Arne Swaminathan, Soumya |
author_role |
author |
author2 |
Peto, Richard Henao-Restrepo, Ana-Maria Preziosi, Marie-Pierre Sathiyamoorthy, Vasee Karim, Quarraisha Abdool Alejandria, Marissa M. Hernández García, César Kieny, Marie-Paule Malekzadeh, Reza Murthy, Srinivas Reddy, K. Srinath Periago, Mirta Roses Hanna, Pierre Abi Ader, Florence Al-Bader, Abdullah M. Alhasawi, Almonther Allum, Emma Alotaibi, Athari Alvarez-Moreno, Carlos A. Appadoo, Sheila Asiri, Abdullah Aukrust, Pål Barratt-Due, Andreas Bellani, Samir Branca, Mattia Cappel-Porter, Heike B. C. Cerrato, Nery Chow, Ting S. Como, Najada Eustace, Joe García, Patricia J. Godbole, Sheela Gotuzzo, Eduardo Griskevicius, Laimonas Hamra, Rasha Hassan, Mariam Hassany, Mohamed Hutton, David Irmansyah, Irmansyah Jancoriene, Ligita Kirwan, Jana Kumar, Suresh Lennon, Peter Lopardo, Gustavo Lydon, Patrick Magrini, Nicola Maguire, Teresa Manevska, Suzana Manuel, Oriol McGinty, Sibylle Medina, Marco T. Mesa Rubio, María L. Miranda-Montoya, Maria C. Nel, Jeremy Nunes, Estevão Portela Perola, Markus Portolés, Antonio Rasmin, Menaldi R. Raza, Aun Rees, Helen Reges, Paula P. S. Rogers, Chris A. Salami, Kolawole Salvadori, Marina I. Sinani, Narvina Sterne, Jonathan A. C. Stevanovikj, Milena Tacconelli, Evelina Tikkinen, Kari A. O. Trelle, Sven Zaid, Hala Røttingen, John-Arne Swaminathan, Soumya |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hongchao, Pan Peto, Richard Henao-Restrepo, Ana-Maria Preziosi, Marie-Pierre Sathiyamoorthy, Vasee Karim, Quarraisha Abdool Alejandria, Marissa M. Hernández García, César Kieny, Marie-Paule Malekzadeh, Reza Murthy, Srinivas Reddy, K. Srinath Periago, Mirta Roses Hanna, Pierre Abi Ader, Florence Al-Bader, Abdullah M. Alhasawi, Almonther Allum, Emma Alotaibi, Athari Alvarez-Moreno, Carlos A. Appadoo, Sheila Asiri, Abdullah Aukrust, Pål Barratt-Due, Andreas Bellani, Samir Branca, Mattia Cappel-Porter, Heike B. C. Cerrato, Nery Chow, Ting S. Como, Najada Eustace, Joe García, Patricia J. Godbole, Sheela Gotuzzo, Eduardo Griskevicius, Laimonas Hamra, Rasha Hassan, Mariam Hassany, Mohamed Hutton, David Irmansyah, Irmansyah Jancoriene, Ligita Kirwan, Jana Kumar, Suresh Lennon, Peter Lopardo, Gustavo Lydon, Patrick Magrini, Nicola Maguire, Teresa Manevska, Suzana Manuel, Oriol McGinty, Sibylle Medina, Marco T. Mesa Rubio, María L. Miranda-Montoya, Maria C. Nel, Jeremy Nunes, Estevão Portela Perola, Markus Portolés, Antonio Rasmin, Menaldi R. Raza, Aun Rees, Helen Reges, Paula P. S. Rogers, Chris A. Salami, Kolawole Salvadori, Marina I. Sinani, Narvina Sterne, Jonathan A. C. Stevanovikj, Milena Tacconelli, Evelina Tikkinen, Kari A. O. Trelle, Sven Zaid, Hala Røttingen, John-Arne Swaminathan, Soumya |
dc.subject.other.pt_BR.fl_str_mv |
Drogas antivirais reutilizadas COVID-19 Organização Mundial da Saúde OMS |
topic |
Drogas antivirais reutilizadas COVID-19 Organização Mundial da Saúde OMS Re-purposed antiviral drugs COVID-19 World Health Organization WHO |
dc.subject.en.en.fl_str_mv |
Re-purposed antiviral drugs COVID-19 World Health Organization WHO |
description |
Hongchao Pan (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Richard Peto (University of Oxford. Nuffield Department of Population Health. Medical Research Council Population Health Research Unit. Oxford, United Kingdom); Ana-Maria Henao-Restrepo (World Health Organization. Geneva, Switzerland); Marie-Pierre Preziosi (World Health Organization. Geneva, Switzerland); Vasee Sathiyamoorthy (World Health Organization. Geneva, Switzerland); Quarraisha Abdool Karim (Centre for the AIDS Programme of Research in South Africa. Durban, South Africa); Marissa M. Alejandria (University of the Philippines. National Institutes of Health. Institute of National Epidemiology. Manila, Philippines); César Hernández García (Spanish Agency of Medicines and Medical Devices. Madrid, Spain / Hospital Clínico San Carlos. Madrid, Spain); Marie-Paule Kieny (Institut National de la Santé et de la Recherche Médicale. Paris, France); Reza Malekzadeh (Tehran University of Medical Sciences. Digestive Disease Research Institute. Tehran, Iran); Srinivas Murthy (University of British Columbia. Vancouver, Canada); K. Srinath Reddy (Public Health Foundation of India. New Delhi, India); Mirta Roses Periago (National Academy of Sciences of Buenos Aires. Buenos Aires, Argentina); Pierre Abi Hanna (Rafic Hariri University Hospital. Beirut, Lebanon); Florence Ader (Hospices Civils de Lyon. Lyon, France); Abdullah M. Al-Bader (Ministry of Health. Kuwait City, Kuwait); Almonther Alhasawi (Infectious Diseases Hospital. Kuwait City, Kuwait); Emma Allum (University of Bristol. Bristol, United Kingdom); Athari Alotaibi (Ministry for Preventive Health. Riyadh, Saudi Arabia); Carlos A. Alvarez-Moreno (Universidad Nacional de Colombia. Bogotá, Colombia / Clinica Colsanitas. Bogotá, Colombia); Sheila Appadoo (University of Bern. Bern, Switzerland); Abdullah Asiri (Ministry for Preventive Health. Riyadh, Saudi Arabia); Pål Aukrust (Oslo University Hospital. Oslo, Norway); Andreas Barratt-Due (Oslo University Hospital. Oslo, Norway); Samir Bellani (University of Bristol. Bristol, United Kingdom); Mattia Branca (University of Bern. Bern, Switzerland); Heike B.C. Cappel-Porter (University of Bristol. Bristol, United Kingdom); Nery Cerrato (Secretaria de Salud de Honduras. Tegucigalpa, Honduras); Ting S. Chow (Penang Hospital. Penang, Malaysia); Najada Como (University Hospital Center "Mother Teresa". Tirana, Albania); Joe Eustace (University College Cork. HRB Clinical Research Facility. Cork, Ireland); Patricia J. García (Universidad Peruana Cayetano Heredia. Lima, Peru); Sheela Godbole (Indian Council of Medical Research. New Delhi, India / National AIDS Research Institute. Pune, Maharashtra, India); Eduardo Gotuzzo (Universidad Peruana Cayetano Heredia. Lima, Peru); Laimonas Griskevicius (Vilnius University Hospital Santaros Klinikos. Vilnius, Lithuania); Rasha Hamra (Ministry of Public Health. Beirut, Lebanon); Mariam Hassan (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Mohamed Hassany (National Hepatology and Tropical Medicine Research Institute. Cairo, Egypt); David Hutton (University of Bristol. Bristol, United Kingdom); Irmansyah Irmansyah (National Institute of Health Research and Development. Jakarta, Indonesia); Ligita Jancoriene (Vilnius University. Faculty of Medicine. Institute of Clinical Medicine. Vilnius, Lithuania); Jana Kirwan (University of Bristol. Bristol, United Kingdom); Suresh Kumar (Sungai Buloh Hospital. Selangor, Malaysia / Jalan Hospital. Selangor, Malaysia); Peter Lennon (Department of Health and Children. Dublin, Ireland); Gustavo Lopardo (Fundación del Centro de Estudios Infectológicos. Buenos Aires, Argentina); Patrick Lydon (World Health Organization. Geneva, Switzerland); Nicola Magrini (Italian Medicines Agency. Rome, Italy); Teresa Maguire (Department of Health and Children. Dublin, Ireland); Suzana Manevska (Ministry of Health. Skopje, North Macedonia); Oriol Manuel (Lausanne University Hospital. Lausanne, Switzerland); Sibylle McGinty (University of Bern. Bern, Switzerland); Marco T. Medina (Universidad Nacional Autónoma de Honduras. Tegucigalpa, Honduras); María L. Mesa Rubio (Ministry of Health. Bogotá, Colombia); Maria C. Miranda-Montoya (World Health Organization. Geneva, Switzerland); Jeremy Nel (University of the Witwatersrand. Johannesburg, South Africa); Estevão Portela Nunes (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Markus Perola (National Institute for Health and Welfare of Finland. Helsinki, Finland / University of Finland. Helsinki, Finland); Antonio Portolés (Universidade Complutense de Madrid. Madrid, Spain / Spanish Clinical Research Network. Madrid, Spain / Hospital Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos. Madrid, Spain); Menaldi R. Rasmin (Rumah Sakit Umum Pusat Persahabatan. Jakarta, Indonesia); Aun Raza (Shaukat Khanum Memorial Cancer Hospital and Research Centre. Lahore, Pakistan); Helen Rees (Wits Reproductive Health and HIV Institute. Johannesburg, South Africa); Paula P. S. Reges (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil); Chris A. Rogers (University of Bristol. Bristol, United Kingdom); Kolawole Salami (World Health Organization. Geneva, Switzerland); Marina I. Salvadori (Public Health Agency of Canada. Ottawa, Canada); Narvina Sinani (National Agency for Medicines and Medical Devices. Tirana, Albania); Jonathan A. C. Sterne (University of Bristol. Bristol, United Kingdom); Milena Stevanovikj (University Clinic of Infectious Diseases and Febrile Conditions. Skopje, North Macedonia); Evelina Tacconelli (University of Verona. Verona, Italy); Kari A. O. Tikkinen (Helsinki University Hospital. Helsinki, Finland / South Karelian Central Hospital. Lappeenranta, Finland); Sven Trelle (University of Bern. Bern, Switzerland); Hala Zaid (Ministry of Health and Population. Cairo, Egypt); John-Arne Røttingen (Research Council of Norway. Oslo, Norway); Soumya Swaminathan (World Health Organization. Geneva, Switzerland). |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-12-16T19:38:48Z |
dc.date.available.fl_str_mv |
2020-12-16T19:38:48Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
HONGCHAO, Pan et al. Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (preprint). MedRxiv, p. 1-17, 15 Oct. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44945 |
dc.identifier.doi.none.fl_str_mv |
10.1101/2020.10.15.20209817 |
identifier_str_mv |
HONGCHAO, Pan et al. Repurposed antiviral drugs for COVID-19: interim WHO solidarity trial results (preprint). MedRxiv, p. 1-17, 15 Oct. 2020. 10.1101/2020.10.15.20209817 |
url |
https://www.arca.fiocruz.br/handle/icict/44945 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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https://www.arca.fiocruz.br/handle/icict/44967 |
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openAccess |
dc.publisher.none.fl_str_mv |
MedRxiv |
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MedRxiv |
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bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1798324848066297856 |