Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial

Detalhes bibliográficos
Autor(a) principal: Silva, Gilberto M Sperandio da
Data de Publicação: 2012
Outros Autores: Chambela, Mayara C, Sousa, Andrea Silvestre de, Sangenis, Luiz Henrique Conde, Xavier, Sergio Salles, Costa, Andrea R, Brasil, Pedro Emmanuel Alvarenga Americano do, Hasslocher-Moreno, Alejandro Marcel, Saraiva, Roberto M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55450
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Gilberto M Sperandio daChambela, Mayara CSousa, Andrea Silvestre deSangenis, Luiz Henrique CondeXavier, Sergio SallesCosta, Andrea RBrasil, Pedro Emmanuel Alvarenga Americano doHasslocher-Moreno, Alejandro MarcelSaraiva, Roberto M2022-11-04T11:31:44Z2022-11-04T11:31:44Z2012SILVA, Gilberto M. Sperandio et al. Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure: randomized clinical trial. Trials, v. 13, n. 244. p. 1-7, 2012.1745-6215https://www.arca.fiocruz.br/handle/icict/5545010.1186/1745-6215-13-244engBMCImpact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: Pharmaceutical care is the direct interaction between pharmacist and patient, in order to improve therapeutic compliance, promote adequate pharmacotherapeutic follow-up, and improve quality of life. Pharmaceutical care may be effective in reducing complications and in improving the quality of life of patients with chronic diseases, like Chagas heart disease, while bringing a positive impact on health system costs. The morbidity and mortality indexes for patients with Chagas heart disease are high, especially if this heart disease is complicated by heart failure. In this setting, we hypothesize that pharmaceutical care might be an important tool for the clinical management of these patients by improving their quality of life, as a better compliance to their treatment and the avoidance and prompt correction of drug-related problems will minimize their symptoms, improve their functional class, and decrease the number of hospital admissions. Therefore, the aim of this trial is to evaluate the contribution of pharmaceutical care to clinical treatment of patients with Chagas heart disease complicated by heart failure. Methods/design: A prospective, single-center randomized clinical trial will be conducted in patients with Chagas heart disease complicated by heart failure. A total of 88 patients will be randomly assigned into two parallel groups: an intervention group will receive standard care and pharmaceutical care, and a control group will receive only standard care. Both groups will be subjected to a follow-up period of 12 months. The primary outcome of this trial is the evaluation of quality of life, measured by the 36-item short-form and the Minnesota Living with Heart Failure Questionnaire. Secondary outcomes include drug-related problems, exercise tolerance as measured by the standard six-minute-walk test, and compliance. Discussion: Patients with Chagas heart disease complicated by heart failure under pharmaceutical care are expected to improve their quality of life, present with a lower incidence of drug-related problems, improve their functional capacity, and improve in their compliance to treatment.Chagas diseaseHeart failurePharmaceutical careQuality of lifeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55450/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALImpact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial.pdfImpact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial.pdfMain 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dc.title.en_US.fl_str_mv Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
title Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
spellingShingle Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
Silva, Gilberto M Sperandio da
Chagas disease
Heart failure
Pharmaceutical care
Quality of life
title_short Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
title_full Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
title_fullStr Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
title_full_unstemmed Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
title_sort Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure Randomized clinical trial
author Silva, Gilberto M Sperandio da
author_facet Silva, Gilberto M Sperandio da
Chambela, Mayara C
Sousa, Andrea Silvestre de
Sangenis, Luiz Henrique Conde
Xavier, Sergio Salles
Costa, Andrea R
Brasil, Pedro Emmanuel Alvarenga Americano do
Hasslocher-Moreno, Alejandro Marcel
Saraiva, Roberto M
author_role author
author2 Chambela, Mayara C
Sousa, Andrea Silvestre de
Sangenis, Luiz Henrique Conde
Xavier, Sergio Salles
Costa, Andrea R
Brasil, Pedro Emmanuel Alvarenga Americano do
Hasslocher-Moreno, Alejandro Marcel
Saraiva, Roberto M
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Gilberto M Sperandio da
Chambela, Mayara C
Sousa, Andrea Silvestre de
Sangenis, Luiz Henrique Conde
Xavier, Sergio Salles
Costa, Andrea R
Brasil, Pedro Emmanuel Alvarenga Americano do
Hasslocher-Moreno, Alejandro Marcel
Saraiva, Roberto M
dc.subject.en.en_US.fl_str_mv Chagas disease
Heart failure
Pharmaceutical care
Quality of life
topic Chagas disease
Heart failure
Pharmaceutical care
Quality of life
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2022-11-04T11:31:44Z
dc.date.available.fl_str_mv 2022-11-04T11:31:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Gilberto M. Sperandio et al. Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure: randomized clinical trial. Trials, v. 13, n. 244. p. 1-7, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55450
dc.identifier.issn.en_US.fl_str_mv 1745-6215
dc.identifier.doi.none.fl_str_mv 10.1186/1745-6215-13-244
identifier_str_mv SILVA, Gilberto M. Sperandio et al. Impact of pharmaceutical care on the quality of life of patients with Chagas disease and heart failure: randomized clinical trial. Trials, v. 13, n. 244. p. 1-7, 2012.
1745-6215
10.1186/1745-6215-13-244
url https://www.arca.fiocruz.br/handle/icict/55450
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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