Plasmodium falciparum Induces trained Innate Immunity

Detalhes bibliográficos
Autor(a) principal: Schrum, Jacob E.
Data de Publicação: 2018
Outros Autores: Crabtree, Juliet N., Dobbs, Katherine R., Kiritsy, Michael C., Reed, George W., Gazzinelli, Ricardo Tostes, Netea, Mihai G., Kazura, James W., Dent, Arlene E., Fitzgerald, Katherine A., Golenbock, David Taylor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32685
Resumo: 2020-01-01
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spelling Schrum, Jacob E.Crabtree, Juliet N.Dobbs, Katherine R.Kiritsy, Michael C.Reed, George W.Gazzinelli, Ricardo TostesNetea, Mihai G.Kazura, James W.Dent, Arlene E.Fitzgerald, Katherine A.Golenbock, David Taylor2019-04-23T16:58:10Z2019-04-23T16:58:10Z2018SCHRUM, Jacob E et al. Plasmodium falciparum Induces trained Innate Immunity. The Journal of immunology, v. 200, n. 4, p. 1243-1248, 2018.0022-1767https://www.arca.fiocruz.br/handle/icict/3268510.4049/jimmunol.1701010engThe American Association of ImmunologistsMaláriaPlasmodium falciparumMalariaPlasmodium falciparumPlasmodium falciparum Induces trained Innate Immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA.Department of Pediatrics. Rainbow Babies and Children's Hospital. Cleveland, OH, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA / Corrona. LLC, Southborough, MA, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA / Department of Pediatrics. Rainbow Babies and Children's Hospital. Cleveland, OH, USA / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Department of Internal Medicine and Radboud Center for Infectious Diseases. Radboud University Medical Center. Nijmegen, the Netherlands.Center for Global Health and Disease. Case Western Reserve University. Cleveland, OH, USA.Department of Pediatrics. Rainbow Babies and Children's Hospital. Cleveland, OH 44106 / Center for Global Health and Disease, Case Western Reserve University, Cleveland, OH, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA.Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA.Malarial infection in naive individuals induces a robust innate immune response. In the recently described model of innate immune memory, an initial stimulus primes the innate immune system to either hyperrespond (termed training) or hyporespond (tolerance) to subsequent immune challenge. Previous work in both mice and humans demonstrated that infection with malaria can both serve as a priming stimulus and promote tolerance to subsequent infection. In this study, we demonstrate that initial stimulation with Plasmodium falciparum-infected RBCs or the malaria crystal hemozoin induced human adherent PBMCs to hyperrespond to subsequent ligation of TLR2. This hyperresponsiveness correlated with increased H3K4me3 at important immunometabolic promoters, and these epigenetic modifications were also seen in Kenyan children naturally infected with malaria. However, the use of epigenetic and metabolic inhibitors indicated that the induction of trained immunity by malaria and its ligands may occur via a previously unrecognized mechanism(s).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/32685/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCutting Edge.pdfCutting Edge.pdfapplication/pdf513714https://www.arca.fiocruz.br/bitstream/icict/32685/2/Cutting%20Edge.pdf924278a789caaa3caadfaeec935aa581MD52TEXTCutting Edge.pdf.txtCutting Edge.pdf.txtExtracted texttext/plain34886https://www.arca.fiocruz.br/bitstream/icict/32685/3/Cutting%20Edge.pdf.txt5f63f51a523bff70615326317429ca8fMD53icict/326852021-03-24 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dc.title.pt_BR.fl_str_mv Plasmodium falciparum Induces trained Innate Immunity
title Plasmodium falciparum Induces trained Innate Immunity
spellingShingle Plasmodium falciparum Induces trained Innate Immunity
Schrum, Jacob E.
Malária
Plasmodium falciparum
Malaria
Plasmodium falciparum
title_short Plasmodium falciparum Induces trained Innate Immunity
title_full Plasmodium falciparum Induces trained Innate Immunity
title_fullStr Plasmodium falciparum Induces trained Innate Immunity
title_full_unstemmed Plasmodium falciparum Induces trained Innate Immunity
title_sort Plasmodium falciparum Induces trained Innate Immunity
author Schrum, Jacob E.
author_facet Schrum, Jacob E.
Crabtree, Juliet N.
Dobbs, Katherine R.
Kiritsy, Michael C.
Reed, George W.
Gazzinelli, Ricardo Tostes
Netea, Mihai G.
Kazura, James W.
Dent, Arlene E.
Fitzgerald, Katherine A.
Golenbock, David Taylor
author_role author
author2 Crabtree, Juliet N.
Dobbs, Katherine R.
Kiritsy, Michael C.
Reed, George W.
Gazzinelli, Ricardo Tostes
Netea, Mihai G.
Kazura, James W.
Dent, Arlene E.
Fitzgerald, Katherine A.
Golenbock, David Taylor
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schrum, Jacob E.
Crabtree, Juliet N.
Dobbs, Katherine R.
Kiritsy, Michael C.
Reed, George W.
Gazzinelli, Ricardo Tostes
Netea, Mihai G.
Kazura, James W.
Dent, Arlene E.
Fitzgerald, Katherine A.
Golenbock, David Taylor
dc.subject.other.pt_BR.fl_str_mv Malária
Plasmodium falciparum
topic Malária
Plasmodium falciparum
Malaria
Plasmodium falciparum
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium falciparum
description 2020-01-01
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-04-23T16:58:10Z
dc.date.available.fl_str_mv 2019-04-23T16:58:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHRUM, Jacob E et al. Plasmodium falciparum Induces trained Innate Immunity. The Journal of immunology, v. 200, n. 4, p. 1243-1248, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32685
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.1701010
identifier_str_mv SCHRUM, Jacob E et al. Plasmodium falciparum Induces trained Innate Immunity. The Journal of immunology, v. 200, n. 4, p. 1243-1248, 2018.
0022-1767
10.4049/jimmunol.1701010
url https://www.arca.fiocruz.br/handle/icict/32685
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The American Association of Immunologists
publisher.none.fl_str_mv The American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32685/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32685/2/Cutting%20Edge.pdf
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