Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Brasil, Pedro Emmanuel Alvarenga Americano do
Data de Publicação: 2016
Outros Autores: Castro, Rodolfo, Castro, Liane de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29300
Resumo: Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Doença de Chagas, Rio de Janeiro, RJ, Brasil
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spelling Brasil, Pedro Emmanuel Alvarenga Americano doCastro, RodolfoCastro, Liane de2018-10-03T17:49:55Z2018-10-03T17:49:55Z2016DO BRASIL, P. E. A. A.; CASTRO, R.; CASTRO, L. Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-Analysis. Memórias do Instituto Oswaldo Cruz, v. 111, n. 1, p. 1-19, 2016.0074-0276https://www.arca.fiocruz.br/handle/icict/2930010.1590/0074-02760150296engCommercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Doença de Chagas, Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil./ Universidade Federal do Estado do Rio de Janeiro, Instituto de Saúde Coletiva, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Farmacogenética, Rio de Janeiro, RJ, BrasilChronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA or PCR for the diagnosis of chronic Chagas disease were systematically searched in PubMed, Scopus, Embase, ISI Web, and LILACS through the bibliography from 1980-2014 and by contact with the manufacturers. The risk of bias was assessed with QUADAS-2. Heterogeneity was estimated with the I2 statistic. Accuracies provided by the manufacturers usually overestimate the accuracy provided by academia. The risk of bias is high in most tests and in most QUADAS dimensions. Heterogeneity is high in either sensitivity, specificity, or both. The evidence regarding commercial ELISA and ELISA-rec sensitivity and specificity indicates that there is overestimation. The current recommendation to use two simultaneous serological tests can be supported by the risk of bias analysis and the amount of heterogeneity but not by the observed accuracies. The usefulness of PCR tests are debatable and health care providers should not order them on a routine basis. PCR may be used in selected cases due to its potential to detect seronegative subjects.Chagas diseaseTrypanosoma cruziDiagnosisPolymerase chain reactionEnzyme-linked immunosorbent assayinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29300/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCommercial enzyme-linked immunosorbent assay versus polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdfCommercial enzyme-linked immunosorbent assay versus polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdfapplication/pdf3967546https://www.arca.fiocruz.br/bitstream/icict/29300/2/Commercial%20enzyme-linked%20immunosorbent%20assay%20versus%20polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdff43000e3cde7142b8a2c0987e53572f7MD52TEXTCommercial enzyme-linked immunosorbent assay versus polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdf.txtCommercial enzyme-linked immunosorbent assay versus polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdf.txtExtracted texttext/plain86153https://www.arca.fiocruz.br/bitstream/icict/29300/3/Commercial%20enzyme-linked%20immunosorbent%20assay%20versus%20polymerase_Rodolfo_Castro_etal_INI_Lapclin-AIDS_2016.pdf.txt3524b87908a29b7261da9c738dbd1981MD53icict/293002019-04-15 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dc.title.pt_BR.fl_str_mv Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
title Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
spellingShingle Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
Brasil, Pedro Emmanuel Alvarenga Americano do
Chagas disease
Trypanosoma cruzi
Diagnosis
Polymerase chain reaction
Enzyme-linked immunosorbent assay
title_short Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
title_full Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
title_fullStr Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
title_full_unstemmed Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
title_sort Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis
author Brasil, Pedro Emmanuel Alvarenga Americano do
author_facet Brasil, Pedro Emmanuel Alvarenga Americano do
Castro, Rodolfo
Castro, Liane de
author_role author
author2 Castro, Rodolfo
Castro, Liane de
author2_role author
author
dc.contributor.author.fl_str_mv Brasil, Pedro Emmanuel Alvarenga Americano do
Castro, Rodolfo
Castro, Liane de
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Trypanosoma cruzi
Diagnosis
Polymerase chain reaction
Enzyme-linked immunosorbent assay
topic Chagas disease
Trypanosoma cruzi
Diagnosis
Polymerase chain reaction
Enzyme-linked immunosorbent assay
description Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica em Doença de Chagas, Rio de Janeiro, RJ, Brasil
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2018-10-03T17:49:55Z
dc.date.available.fl_str_mv 2018-10-03T17:49:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv DO BRASIL, P. E. A. A.; CASTRO, R.; CASTRO, L. Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-Analysis. Memórias do Instituto Oswaldo Cruz, v. 111, n. 1, p. 1-19, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29300
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760150296
identifier_str_mv DO BRASIL, P. E. A. A.; CASTRO, R.; CASTRO, L. Commercial enzyme-linked immunosorbent assay versus polymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-Analysis. Memórias do Instituto Oswaldo Cruz, v. 111, n. 1, p. 1-19, 2016.
0074-0276
10.1590/0074-02760150296
url https://www.arca.fiocruz.br/handle/icict/29300
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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