Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15195 |
Resumo: | Federal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil |
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Rocha, Paulo NovisMacedo, Michael NascimentoKobayashi, Carla DinaméricaMoreno, LisGuimarães, Luiz Henrique SantosMachado, Paulo Roberto LimaBadaró, Roberto José da SilvaCarvalho Filho, Edgar MarcelinoGlesby, Marshall Jay2016-08-04T16:52:11Z2016-08-04T16:52:11Z2015ROCHA, P. N. et al. Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury. Antimicrobial Agents and Chemotherapy, v. 59, n. 11, p. 6913-6921, 2015.0066-4804https://www.arca.fiocruz.br/handle/icict/1519510.1128/AAC.01079-15engAmerican Society for MicrobiologyRole of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFederal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Divisão de Doenças Infecciosas. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology in Tropical Diseases. INCT-DT. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology in Tropical Diseases. INCT-DT. Salvador, BA, BrasilFederal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Professor Edgard Santos. Divisão de Doenças Infecciosas. Salvador, BA, BrasilFederal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology in Tropical Diseases. INCT-DT. Salvador, BA, BrasilWeill Cornell Medical College. Department of Medicine. New York, NY, USADetermination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would be an early biomarker of drug nephrotoxicity. To test this, we studied hemodynamically stable patients treated with amphotericin B (AmB). We measured the SCr and UrNGAL levels at the baseline and daily after initiation of AmB up to day 14 or development of AKI by the use of the SCr criterion. AKI was defined according to a Kidney Disease: Improving Global Outcomes (KDIGO) criterion (an increase in the SCr level by ≥0.3 mg/dl within 48 h or an SCr level ≥1.5 times the baseline level within 7 days). We studied 24 patients with a mean age of 48.4 ± 16.4 years. Most patients were male, and the patients received AmB (12 received AmB deoxycholate and 12 received liposomal AmB) for the treatment of leishmaniasis (91.7%). Overall, 17/24 patients fulfilled a KDIGO criterion for AKI. Peak UrNGAL levels were higher in patients with AKI than in patients without AKI and in recipients of AmB deoxycholate than in recipients of liposomal AmB. The diagnostic performance of the UrNGAL level on day 5 for the detection of AKI was moderate, with the area under the curve (AUC) being 0.68 (95% confidence interval [CI], 0.41 to 0.95). In the subgroup receiving AmB deoxycholate, however, the AUC rose to 0.89 (95% CI, 0.67 to 1.00). In a patient-level analysis, we found that AKI could be detected 3.2 days earlier by the use of the UrNGAL criterion than by the use of the SCr criterion (times to AKI by the UrNGAL and SCr criteria, 3.7 ± 2.5 versus 6.9 ± 3.3 days, respectively; P = 0.001). Future studies should evaluate if a treatment strategy oriented toward evaluation of UrNGAL levels will improve outcomes. These findings for AmB-induced AKI in leishmaniasis patients could serve as a basis for the investigation of urine biomarkers in the early detection of drug nephrotoxicity in other clinical settings.Amphotericin BCreatinineBiomarkersHumansAcute kidney injuryDrug combinationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15195/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRocha PN Role of urine....pdfRocha PN Role of urine....pdfapplication/pdf637038https://www.arca.fiocruz.br/bitstream/icict/15195/2/Rocha%20PN%20Role%20of%20urine....pdfaa90cec44f806350890e5969f36ce47eMD52TEXTRocha PN Role of urine....pdf.txtRocha PN Role of urine....pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| title |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| spellingShingle |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury Rocha, Paulo Novis Amphotericin B Creatinine Biomarkers Humans Acute kidney injury Drug combination |
| title_short |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| title_full |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| title_fullStr |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| title_full_unstemmed |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| title_sort |
Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury |
| author |
Rocha, Paulo Novis |
| author_facet |
Rocha, Paulo Novis Macedo, Michael Nascimento Kobayashi, Carla Dinamérica Moreno, Lis Guimarães, Luiz Henrique Santos Machado, Paulo Roberto Lima Badaró, Roberto José da Silva Carvalho Filho, Edgar Marcelino Glesby, Marshall Jay |
| author_role |
author |
| author2 |
Macedo, Michael Nascimento Kobayashi, Carla Dinamérica Moreno, Lis Guimarães, Luiz Henrique Santos Machado, Paulo Roberto Lima Badaró, Roberto José da Silva Carvalho Filho, Edgar Marcelino Glesby, Marshall Jay |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Paulo Novis Macedo, Michael Nascimento Kobayashi, Carla Dinamérica Moreno, Lis Guimarães, Luiz Henrique Santos Machado, Paulo Roberto Lima Badaró, Roberto José da Silva Carvalho Filho, Edgar Marcelino Glesby, Marshall Jay |
| dc.subject.en.pt_BR.fl_str_mv |
Amphotericin B Creatinine Biomarkers Humans Acute kidney injury Drug combination |
| topic |
Amphotericin B Creatinine Biomarkers Humans Acute kidney injury Drug combination |
| description |
Federal University of Bahia. Medical School of Bahia. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil |
| publishDate |
2015 |
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2015 |
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2016-08-04T16:52:11Z |
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2016-08-04T16:52:11Z |
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ROCHA, P. N. et al. Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury. Antimicrobial Agents and Chemotherapy, v. 59, n. 11, p. 6913-6921, 2015. |
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https://www.arca.fiocruz.br/handle/icict/15195 |
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0066-4804 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.01079-15 |
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ROCHA, P. N. et al. Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury. Antimicrobial Agents and Chemotherapy, v. 59, n. 11, p. 6913-6921, 2015. 0066-4804 10.1128/AAC.01079-15 |
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American Society for Microbiology |
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American Society for Microbiology |
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