Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Azevedo, Christianne Terra de Oliveira
Data de Publicação: 2016
Outros Autores: Brasil, Pedro Emmanuel Alvarenga Americano do, Guida, Letícia, Moreira, Maria Elisabeth Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31494
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
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spelling Azevedo, Christianne Terra de OliveiraBrasil, Pedro Emmanuel Alvarenga Americano doGuida, LetíciaMoreira, Maria Elisabeth Lopes2019-02-08T13:13:27Z2019-02-08T13:13:27Z2016AZEVEDO, Christianne Terra de Oliveira et al. Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis, Plos One, p. 1-26, 7 Apr. 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/3149410.1371/journal.pone.01499381932-6203engPublic Library of SciencePerformance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Introduction: Congenital infection caused by Toxoplasma gondii can cause serious damage that can be diagnosed in utero or at birth, although most infants are asymptomatic at birth. Prenatal diagnosis of congenital toxoplasmosis considerably improves the prognosis and outcome for infected infants. For this reason, an assay for the quick, sensitive, and safe diagnosis of fetal toxoplasmosis is desirable. Goal: To systematically review the performance of polymerase chain reaction (PCR) analysis of the amniotic fluid of pregnant women with recent serological toxoplasmosis diagnoses for the diagnosis of fetal toxoplasmosis. Method: A systematic literature review was conducted via a search of electronic databases; the literature included primary studies of the diagnostic accuracy of PCR analysis of amniotic fluid from pregnant women who seroconverted during pregnancy. The PCR test was compared to a gold standard for diagnosis. Results: A total of 1.269 summaries were obtained from the electronic database and reviewed, and 20 studies, comprising 4.171 samples, met the established inclusion criteria and were included in the review. The following results were obtained: studies about PCR assays for fetal toxoplasmosis are generally susceptible to bias; reports of the tests’ use lack critical information; the protocols varied among studies; the heterogeneity among studies was concentrated in the tests’ sensitivity; there was evidence that the sensitivity of the tests increases with time, as represented by the trimester; and there was more heterogeneity among studies in which there was more time between maternal diagnosis and fetal testing. The sensitivity of the method, if performed up to five weeks after maternal diagnosis, was 87% and specificity was 99%. Conclusion: The global sensitivity heterogeneity of the PCR test in this review was 66.5% (I2). The tests show low evidence of heterogeneity with a sensitivity of 87% and specificity of 99% when performed up to five weeks after maternal diagnosis. The test has a known performance and could be recommended for use up to five weeks after maternal diagnosis, when there is suspicion of fetal toxoplasmosis.Polymerase chain reaction analysisAmniotic fluidDiagnosisCongenital toxoplasmosisToxoplasmosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31494/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Azevedo_Christianne_etal_INI_2016.PDFve_Azevedo_Christianne_etal_INI_2016.PDFapplication/pdf5232061https://www.arca.fiocruz.br/bitstream/icict/31494/2/ve_Azevedo_Christianne_etal_INI_2016.PDFeb9b80fa1d5c302a4cd0c1059f181745MD52TEXTve_Azevedo_Christianne_etal_INI_2016.PDF.txtve_Azevedo_Christianne_etal_INI_2016.PDF.txtExtracted 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dc.title.pt_BR.fl_str_mv Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
title Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
spellingShingle Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
Azevedo, Christianne Terra de Oliveira
Polymerase chain reaction analysis
Amniotic fluid
Diagnosis
Congenital toxoplasmosis
Toxoplasmosis
title_short Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
title_full Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
title_fullStr Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
title_full_unstemmed Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
title_sort Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis
author Azevedo, Christianne Terra de Oliveira
author_facet Azevedo, Christianne Terra de Oliveira
Brasil, Pedro Emmanuel Alvarenga Americano do
Guida, Letícia
Moreira, Maria Elisabeth Lopes
author_role author
author2 Brasil, Pedro Emmanuel Alvarenga Americano do
Guida, Letícia
Moreira, Maria Elisabeth Lopes
author2_role author
author
author
dc.contributor.author.fl_str_mv Azevedo, Christianne Terra de Oliveira
Brasil, Pedro Emmanuel Alvarenga Americano do
Guida, Letícia
Moreira, Maria Elisabeth Lopes
dc.subject.en.pt_BR.fl_str_mv Polymerase chain reaction analysis
Amniotic fluid
Diagnosis
Congenital toxoplasmosis
Toxoplasmosis
topic Polymerase chain reaction analysis
Amniotic fluid
Diagnosis
Congenital toxoplasmosis
Toxoplasmosis
description Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-02-08T13:13:27Z
dc.date.available.fl_str_mv 2019-02-08T13:13:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEVEDO, Christianne Terra de Oliveira et al. Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis, Plos One, p. 1-26, 7 Apr. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31494
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0149938
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv AZEVEDO, Christianne Terra de Oliveira et al. Performance of polymerase chain reaction analysis of the amniotic fluid of pregnant women for diagnosis of congenital toxoplasmosis: a systematic review and meta-analysis, Plos One, p. 1-26, 7 Apr. 2016.
1932-6203
10.1371/journal.pone.0149938
url https://www.arca.fiocruz.br/handle/icict/31494
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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