Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59307 |
Resumo: | Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. |
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Mendes, Veronica G.Rimolo, LorenaLima, Ana Carolina B. deFerreira, Roberto R.Oliveira, Luciano S.Nisimura, Lindice M.Horita, Samuel I. M.Costa, Andréa R.Silva, Gilberto Marcelo S. daSangenis, Luiz Henrique C.Mendes, Fernanda S. N. S.Sousa, Andrea S.Veloso, Henrique H.Holanda, Marcelo T.Mediano, Mauro F. F.Waghabi, Mariana C.Garzoni, Luciana R.Moreira, Otacílio C.Britto, ConstançaCunha, Ademir B.Hasslocher-Moreno, Alejandro MarcelSaraiva, Roberto M.2023-06-30T15:01:47Z2023-06-30T15:01:47Z2023MENDES, Veronica G. et al. Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease. Journal of the American Heart Association, v. 12, n. 12, p. 1-25, June 2023.2047-9980https://www.arca.fiocruz.br/handle/icict/5930710.1161/JAHA.122.028810engWileyAnálise de tensão bidimensionalEcocardiografia tridimensionalDoença de ChagasMortalidadePrognósticoChagas diseaseMortalityPrognosisDimensional strain analysisDimensional echocardiographyBiomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Antonio Pedro University Hospital. Niterói, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Molecular Biology and Endemic Diseases Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Applied Genomics and Bioinnovations. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Innovations in Therapies. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Innovations in Therapies, Education and Bioproducts. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Applied Genomics and Bioinnovations. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Innovations in Therapies, Education and Bioproducts. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Molecular Virology and Parasitology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Molecular Biology and Endemic Diseases Laboratory. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Antonio Pedro University Hospital. Niterói, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.Background: Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not been well studied. Methods and Results: There were 361 patients with chronic CD (57.6% men, 61±11 years of age, clinical forms: indeterminate 27.1%, cardiac 56.6%, digestive 3.6%, cardiodigestive 12.7%) included in this single-center, observational, prospective longitudinal study. Echocardiographic evaluation included strain analyses of left atrial, left ventricular (LV), and right ventricular and 3-dimensional analyses of left atrial and LV volumes. Biomarkers included cardiac troponin I, brain natriuretic peptide, transforming growth factor β1, tumor necrosis factor, matrix metalloproteinases, and Trypanosoma cruzi polymerase chain reaction. The studied end point was a composite of CD-related mortality, heart transplant, hospital admission due to worsening heart failure, or new cardiac device insertion. Event-free survival was analyzed by multivariable regression analyses adjusted for competing risks. P values <0.05 were considered significant. The composite event occurred in 79 patients after 4.9±2.0 years follow-up. LV end-diastolic volume (hazard ratio [HR], 1.01 [95% CI, 1.00-1.02]; P=0.02), peak negative global atrial strain (HR, 1.08 [95% CI, 1.00-1.17]; P=0.04), LV global circumferential strain (HR, 1.12 [95% CI, 1.04-1.21]; P=0.003), LV torsion (HR, 0.55 [95% CI, 0.35-0.81]; P=0.003), brain natriuretic peptide (HR, 2.03 [95% CI, 1.23-3.34]; P=0.005), and positive T cruzi polymerase chain reaction (HR, 1.80 [95% CI, 1.12-2.91]; P=0.01) were end point predictors independent from age, sex, 2-dimensional echocardiographic indexes, hypertension, previous cardiac device, and CD cardiac form. Conclusions: Two-dimensional strain- and 3-dimensional-derived parameters, brain natriuretic peptide, and positive T cruzi polymerase chain reaction can be useful for prediction of CD cardiovascular events.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59307/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVeronicaMendesPLucianaGarzoni_etal_IOC_2023.pdfVeronicaMendesPLucianaGarzoni_etal_IOC_2023.pdfapplication/pdf681881https://www.arca.fiocruz.br/bitstream/icict/59307/2/VeronicaMendesPLucianaGarzoni_etal_IOC_2023.pdf375a6c97f09fc20180e7a8053aac17ebMD52icict/593072023-09-04 10:54:02.652oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T13:54:02Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
title |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
spellingShingle |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease Mendes, Veronica G. Análise de tensão bidimensional Ecocardiografia tridimensional Doença de Chagas Mortalidade Prognóstico Chagas disease Mortality Prognosis Dimensional strain analysis Dimensional echocardiography |
title_short |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
title_full |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
title_fullStr |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
title_full_unstemmed |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
title_sort |
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease |
author |
Mendes, Veronica G. |
author_facet |
Mendes, Veronica G. Rimolo, Lorena Lima, Ana Carolina B. de Ferreira, Roberto R. Oliveira, Luciano S. Nisimura, Lindice M. Horita, Samuel I. M. Costa, Andréa R. Silva, Gilberto Marcelo S. da Sangenis, Luiz Henrique C. Mendes, Fernanda S. N. S. Sousa, Andrea S. Veloso, Henrique H. Holanda, Marcelo T. Mediano, Mauro F. F. Waghabi, Mariana C. Garzoni, Luciana R. Moreira, Otacílio C. Britto, Constança Cunha, Ademir B. Hasslocher-Moreno, Alejandro Marcel Saraiva, Roberto M. |
author_role |
author |
author2 |
Rimolo, Lorena Lima, Ana Carolina B. de Ferreira, Roberto R. Oliveira, Luciano S. Nisimura, Lindice M. Horita, Samuel I. M. Costa, Andréa R. Silva, Gilberto Marcelo S. da Sangenis, Luiz Henrique C. Mendes, Fernanda S. N. S. Sousa, Andrea S. Veloso, Henrique H. Holanda, Marcelo T. Mediano, Mauro F. F. Waghabi, Mariana C. Garzoni, Luciana R. Moreira, Otacílio C. Britto, Constança Cunha, Ademir B. Hasslocher-Moreno, Alejandro Marcel Saraiva, Roberto M. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mendes, Veronica G. Rimolo, Lorena Lima, Ana Carolina B. de Ferreira, Roberto R. Oliveira, Luciano S. Nisimura, Lindice M. Horita, Samuel I. M. Costa, Andréa R. Silva, Gilberto Marcelo S. da Sangenis, Luiz Henrique C. Mendes, Fernanda S. N. S. Sousa, Andrea S. Veloso, Henrique H. Holanda, Marcelo T. Mediano, Mauro F. F. Waghabi, Mariana C. Garzoni, Luciana R. Moreira, Otacílio C. Britto, Constança Cunha, Ademir B. Hasslocher-Moreno, Alejandro Marcel Saraiva, Roberto M. |
dc.subject.other.en_US.fl_str_mv |
Análise de tensão bidimensional Ecocardiografia tridimensional Doença de Chagas Mortalidade Prognóstico |
topic |
Análise de tensão bidimensional Ecocardiografia tridimensional Doença de Chagas Mortalidade Prognóstico Chagas disease Mortality Prognosis Dimensional strain analysis Dimensional echocardiography |
dc.subject.en.en_US.fl_str_mv |
Chagas disease Mortality Prognosis Dimensional strain analysis Dimensional echocardiography |
description |
Oswaldo Cruz Foundation. Chagas Disease Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-06-30T15:01:47Z |
dc.date.available.fl_str_mv |
2023-06-30T15:01:47Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MENDES, Veronica G. et al. Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease. Journal of the American Heart Association, v. 12, n. 12, p. 1-25, June 2023. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59307 |
dc.identifier.issn.en_US.fl_str_mv |
2047-9980 |
dc.identifier.doi.none.fl_str_mv |
10.1161/JAHA.122.028810 |
identifier_str_mv |
MENDES, Veronica G. et al. Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease. Journal of the American Heart Association, v. 12, n. 12, p. 1-25, June 2023. 2047-9980 10.1161/JAHA.122.028810 |
url |
https://www.arca.fiocruz.br/handle/icict/59307 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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