Selection of targets for drug development against protozoan parasites

Detalhes bibliográficos
Autor(a) principal: Azevedo Junior, Walter Filgueira de
Data de Publicação: 2009
Outros Autores: Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9008
Resumo: Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Biociências. Laboratório de Bioquímica Estrutural. Porto Alegre, RS, Brasil
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spelling Azevedo Junior, Walter Filgueira deSoares, Milena Botelho Pereira2014-11-28T17:31:45Z2014-11-28T17:31:45Z2009AZEVEDO JUNIOR, W. F.; SOARES, M. B. P. Selection of targets for drug development against protozoan parasites. Current Drug Targets, v. 10, n. 3, p. 193-201, 2009.1873-5592https://www.arca.fiocruz.br/handle/icict/9008engBentham Science Publishers LtdSelection of targets for drug development against protozoan parasitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Biociências. Laboratório de Bioquímica Estrutural. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, BrasilSequencing of parasite genomes opened the possibity to identify potential protein targets for drug development. Several protein targets have been found in the genome of Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. Bioinformatics analysis is an important tool for the identification of protein targets for drug development against parasitic diseases. In this review we comment about three protein targets, identified in parasite genomes, and discuss the main features that may guide future efforts for virtual screening initiatives.Virtual screeningParasitesMolecular targetsDrug designAntiprotozoários/farmacologiaSistemas de Liberação de MedicamentosInfecções por Protozoários/quimioterapiaAnimaisDesenho de DrogasGenoma de ProtozoárioHumanosDados de Sequência MolecularDados de Sequência MolecularProteínas Quinases/metabolismoInfecções por Protozoários/parasitologiaPurina-Núcleosídeo Fosforilase/efeitos de drogasÁcido Chiquímico/metabolismoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9008/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALAzevedo Jr WF Selection...pdfAzevedo Jr WF Selection...pdfapplication/pdf245429https://www.arca.fiocruz.br/bitstream/icict/9008/2/Azevedo%20Jr%20WF%20Selection...pdf08227ea991936553310168de39c4b26fMD52TEXTAzevedo Jr WF Selection...pdf.txtAzevedo Jr WF Selection...pdf.txtExtracted texttext/plain47612https://www.arca.fiocruz.br/bitstream/icict/9008/3/Azevedo%20Jr%20WF%20Selection...pdf.txt7adcf64cf2cb9ce86b329fb9556a0125MD53icict/90082023-03-15 14:33:11.125oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Selection of targets for drug development against protozoan parasites
title Selection of targets for drug development against protozoan parasites
spellingShingle Selection of targets for drug development against protozoan parasites
Azevedo Junior, Walter Filgueira de
Virtual screening
Parasites
Molecular targets
Drug design
Antiprotozoários/farmacologia
Sistemas de Liberação de Medicamentos
Infecções por Protozoários/quimioterapia
Animais
Desenho de Drogas
Genoma de Protozoário
Humanos
Dados de Sequência Molecular
Dados de Sequência Molecular
Proteínas Quinases/metabolismo
Infecções por Protozoários/parasitologia
Purina-Núcleosídeo Fosforilase/efeitos de drogas
Ácido Chiquímico/metabolismo
title_short Selection of targets for drug development against protozoan parasites
title_full Selection of targets for drug development against protozoan parasites
title_fullStr Selection of targets for drug development against protozoan parasites
title_full_unstemmed Selection of targets for drug development against protozoan parasites
title_sort Selection of targets for drug development against protozoan parasites
author Azevedo Junior, Walter Filgueira de
author_facet Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
author_role author
author2 Soares, Milena Botelho Pereira
author2_role author
dc.contributor.author.fl_str_mv Azevedo Junior, Walter Filgueira de
Soares, Milena Botelho Pereira
dc.subject.en.pt_BR.fl_str_mv Virtual screening
Parasites
Molecular targets
Drug design
topic Virtual screening
Parasites
Molecular targets
Drug design
Antiprotozoários/farmacologia
Sistemas de Liberação de Medicamentos
Infecções por Protozoários/quimioterapia
Animais
Desenho de Drogas
Genoma de Protozoário
Humanos
Dados de Sequência Molecular
Dados de Sequência Molecular
Proteínas Quinases/metabolismo
Infecções por Protozoários/parasitologia
Purina-Núcleosídeo Fosforilase/efeitos de drogas
Ácido Chiquímico/metabolismo
dc.subject.decs.pt_BR.fl_str_mv Antiprotozoários/farmacologia
Sistemas de Liberação de Medicamentos
Infecções por Protozoários/quimioterapia
Animais
Desenho de Drogas
Genoma de Protozoário
Humanos
Dados de Sequência Molecular
Dados de Sequência Molecular
Proteínas Quinases/metabolismo
Infecções por Protozoários/parasitologia
Purina-Núcleosídeo Fosforilase/efeitos de drogas
Ácido Chiquímico/metabolismo
description Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Biociências. Laboratório de Bioquímica Estrutural. Porto Alegre, RS, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-11-28T17:31:45Z
dc.date.available.fl_str_mv 2014-11-28T17:31:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEVEDO JUNIOR, W. F.; SOARES, M. B. P. Selection of targets for drug development against protozoan parasites. Current Drug Targets, v. 10, n. 3, p. 193-201, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9008
dc.identifier.issn.none.fl_str_mv 1873-5592
identifier_str_mv AZEVEDO JUNIOR, W. F.; SOARES, M. B. P. Selection of targets for drug development against protozoan parasites. Current Drug Targets, v. 10, n. 3, p. 193-201, 2009.
1873-5592
url https://www.arca.fiocruz.br/handle/icict/9008
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers Ltd
publisher.none.fl_str_mv Bentham Science Publishers Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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