Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Silva, Luciano Kalabric
Data de Publicação: 2006
Outros Autores: Silva, M. B. S., Rodart, Itatiana Ferreira, Lopes, Gisele Barreto, Costa, F. Q., Melo, M. E., Gusmão, E., Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7549
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
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spelling Silva, Luciano KalabricSilva, M. B. S.Rodart, Itatiana FerreiraLopes, Gisele BarretoCosta, F. Q.Melo, M. E.Gusmão, E.Reis, Mitermayer Galvão dos2014-04-28T16:09:31Z2014-04-28T16:09:31Z2006SILVA, L. K. et al. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 595-602, 2006.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/7549engFaculdade de Medicina de Ribeirao Preto Associacao Brasileira de DivulgacaoPrevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Departamento de Medicina Interna. Salvador, BA, Brasil4Comissão Estadual de Nefrologia. Salvador, BA, BrasilHepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on chronic hemodialysis (HD), despite the important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and the use of recombinant erythropoietin to treat anemia. A cross-sectional study was performed to estimate the prevalence of HCV infection and genotypes among HD patients in Salvador, Northeastern Brazil. Anti- HCV seroprevalence was determined by ELISA in 1243 HD patients from all ten different dialysis centers of the city. HCV infection was confirmed by RT-PCR and genotyping was performed by restriction fragment length polymorphism. Anti-HCV seroprevalence among HD patients was 10.5% (95% CI: 8.8-12.3) (Murex anti-HCV, Abbott Murex, Chicago, IL, USA). Blood samples for qualitative HCV detection and genotyping were collected from 125/130 seropositive HD patients (96.2%). HCV-RNA was detected in 92/125 (73.6%) of the anti-HCV-positive patients. HCV genotype 1 (77.9%) was the most prevalent, followed by genotype 3 (10.5%) and genotype 2 (4.6%). Mixed infections of genotypes 1 and 3 were found in 7.0% of the total number of patients. The present results indicate a significant decrease in anti-HCV prevalence from 23.8% detected in a study carried out in 1994 to 10.5% in the present study. The HCV genotype distribution was closely similar to that observed in other hemodialysis populations in Brazil, in local candidate blood donors and in other groups at risk of transfusion-transmitted infection.Hepatitis CSeroprevalenceViremiaHemodialysisGenotypeBrazilGenótipoHepacivirus/genéticaAnticorpos Anti-Hepatite C/sangueHepatite C/epidemiologiaDiálise Renal/efeitos adversosBrasil/epidemiologiaEstudos TransversaisEletroforese em Gel de ÁgarEnsaio de Imunoadsorção EnzimáticaHepacivirus/imunologiaHepatite C/diagnósticoHepatite C/etiologiaHumanosReação em Cadeia da PolimerasePolimorfismo de Fragmento de RestriçãoPrevalênciaRNA Viral/análiseEstudos Soroepidemiológicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva LK Prevalence of hepatitis....pdfSilva LK Prevalence of hepatitis....pdfapplication/pdf591164https://www.arca.fiocruz.br/bitstream/icict/7549/1/Silva%20LK%20Prevalence%20of%20hepatitis....pdf581c3941f1ff2cefbde86e7579e4a5ecMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7549/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSilva LK Prevalence of hepatitis....pdf.txtSilva LK Prevalence of hepatitis....pdf.txtExtracted texttext/plain30341https://www.arca.fiocruz.br/bitstream/icict/7549/5/Silva%20LK%20Prevalence%20of%20hepatitis....pdf.txt77ee8426648d9a3c148b01cdec167015MD55THUMBNAILSilva LK Prevalence of hepatitis....pdf.jpgSilva LK Prevalence of hepatitis....pdf.jpgGenerated Thumbnailimage/jpeg1692https://www.arca.fiocruz.br/bitstream/icict/7549/4/Silva%20LK%20Prevalence%20of%20hepatitis....pdf.jpgdeaa077dceb35f6a2e1b4ba27f3142f1MD54icict/75492023-03-15 14:33:12.284oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
title Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
spellingShingle Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
Silva, Luciano Kalabric
Hepatitis C
Seroprevalence
Viremia
Hemodialysis
Genotype
Brazil
Genótipo
Hepacivirus/genética
Anticorpos Anti-Hepatite C/sangue
Hepatite C/epidemiologia
Diálise Renal/efeitos adversos
Brasil/epidemiologia
Estudos Transversais
Eletroforese em Gel de Ágar
Ensaio de Imunoadsorção Enzimática
Hepacivirus/imunologia
Hepatite C/diagnóstico
Hepatite C/etiologia
Humanos
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Prevalência
RNA Viral/análise
Estudos Soroepidemiológicos
title_short Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
title_full Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
title_fullStr Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
title_full_unstemmed Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
title_sort Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil
author Silva, Luciano Kalabric
author_facet Silva, Luciano Kalabric
Silva, M. B. S.
Rodart, Itatiana Ferreira
Lopes, Gisele Barreto
Costa, F. Q.
Melo, M. E.
Gusmão, E.
Reis, Mitermayer Galvão dos
author_role author
author2 Silva, M. B. S.
Rodart, Itatiana Ferreira
Lopes, Gisele Barreto
Costa, F. Q.
Melo, M. E.
Gusmão, E.
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Luciano Kalabric
Silva, M. B. S.
Rodart, Itatiana Ferreira
Lopes, Gisele Barreto
Costa, F. Q.
Melo, M. E.
Gusmão, E.
Reis, Mitermayer Galvão dos
dc.subject.en.pt_BR.fl_str_mv Hepatitis C
Seroprevalence
Viremia
Hemodialysis
Genotype
Brazil
topic Hepatitis C
Seroprevalence
Viremia
Hemodialysis
Genotype
Brazil
Genótipo
Hepacivirus/genética
Anticorpos Anti-Hepatite C/sangue
Hepatite C/epidemiologia
Diálise Renal/efeitos adversos
Brasil/epidemiologia
Estudos Transversais
Eletroforese em Gel de Ágar
Ensaio de Imunoadsorção Enzimática
Hepacivirus/imunologia
Hepatite C/diagnóstico
Hepatite C/etiologia
Humanos
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Prevalência
RNA Viral/análise
Estudos Soroepidemiológicos
dc.subject.decs.pt_BR.fl_str_mv Genótipo
Hepacivirus/genética
Anticorpos Anti-Hepatite C/sangue
Hepatite C/epidemiologia
Diálise Renal/efeitos adversos
Brasil/epidemiologia
Estudos Transversais
Eletroforese em Gel de Ágar
Ensaio de Imunoadsorção Enzimática
Hepacivirus/imunologia
Hepatite C/diagnóstico
Hepatite C/etiologia
Humanos
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Prevalência
RNA Viral/análise
Estudos Soroepidemiológicos
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-04-28T16:09:31Z
dc.date.available.fl_str_mv 2014-04-28T16:09:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, L. K. et al. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 595-602, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7549
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv SILVA, L. K. et al. Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 595-602, 2006.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/7549
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto Associacao Brasileira de Divulgacao
publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto Associacao Brasileira de Divulgacao
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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