Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality

Detalhes bibliográficos
Autor(a) principal: Chumbinho, Lucianne C.
Data de Publicação: 2012
Outros Autores: Pizzini, Caroline C., Oliveira, F. de Souza, Batista, Wanderson, Oliveira, Gabriel M. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15702
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Chumbinho, Lucianne C.Pizzini, Caroline C.Oliveira, F. de SouzaBatista, WandersonOliveira, Gabriel M. de2016-09-06T15:35:31Z2016-09-06T15:35:31Z2012CHUMBINHO, Lucianne C. et al. Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality. Journal of Experimental and Integrative Medicine, v.2, n.3, p.199-206, 2012.1309-4572https://www.arca.fiocruz.br/handle/icict/157022146-3298engGESDAV- Foundation for Education, Health, Social Cooperation and Solidairty of the People of the GulhaneTrypanosoma cruziLesão renal agudaMiocardite agudaAcute kidney injuryAcute myocarditisRAASTrypanosoma cruziCardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortalityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Biofilmes e Ensino. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Introduction: Trypanosoma cruzi infection is a serious public health problem in Latin America. Despite positive results from programs directed to the interruption of vectorial transmission, there are still millions of people infected, and a large number, at the risk of infection. Chagas disease is typically associated with cardiac complications, and chronic symptoms include heart failure and megaesophagus development. Objective: In this study, we aimed to evaluate the importance of the cardiorenal axis and renin-angiotensin-aldosterone system (RAAS) activation in experimental T.cruzi infection. We also evaluated the influence of aldosterone and the angiotensin II receptor type 1 (AT1R) on the mortality of infected mice. Methods: BALB/c mice infected with the Y strain of T.cruzi were treated with spironolactone or losartan. We assessed parasitemia, mortality, and renal and cardiac function by using non-invasive methods. Results: Our data show that AT1R promotes an important (and necessary) inotropic positive effect in the heart and minimizes acute kidney injury. Conversely, aldosterone increases the release of K+ and aggravates heart failure. It also has associated effects on the renal, cardiovascular, and cardiac electrical conduction systems. Consequently, the aldosterone antagonist reduced the mortality rate by 50%, whereas the AT1R antagonist increased it by 20%. Conclusions: The RAAS connects the cardiorenal systems, and its components differentially affect the mortality of animals experimentally infected by T.cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15702/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluciane_chumbinho_etal_IOC_212.pdfluciane_chumbinho_etal_IOC_212.pdfapplication/pdf385612https://www.arca.fiocruz.br/bitstream/icict/15702/2/luciane_chumbinho_etal_IOC_212.pdf3f062fe29eaaed0e499883f879402a8eMD52TEXTluciane_chumbinho_etal_IOC_212.pdf.txtluciane_chumbinho_etal_IOC_212.pdf.txtExtracted texttext/plain32451https://www.arca.fiocruz.br/bitstream/icict/15702/3/luciane_chumbinho_etal_IOC_212.pdf.txt5bceecba2f80d603667486d8a5565fc6MD53icict/157022018-04-02 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dc.title.pt_BR.fl_str_mv Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
title Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
spellingShingle Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
Chumbinho, Lucianne C.
Trypanosoma cruzi
Lesão renal aguda
Miocardite aguda
Acute kidney injury
Acute myocarditis
RAAS
Trypanosoma cruzi
title_short Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
title_full Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
title_fullStr Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
title_full_unstemmed Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
title_sort Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality
author Chumbinho, Lucianne C.
author_facet Chumbinho, Lucianne C.
Pizzini, Caroline C.
Oliveira, F. de Souza
Batista, Wanderson
Oliveira, Gabriel M. de
author_role author
author2 Pizzini, Caroline C.
Oliveira, F. de Souza
Batista, Wanderson
Oliveira, Gabriel M. de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Chumbinho, Lucianne C.
Pizzini, Caroline C.
Oliveira, F. de Souza
Batista, Wanderson
Oliveira, Gabriel M. de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Lesão renal aguda
Miocardite aguda
topic Trypanosoma cruzi
Lesão renal aguda
Miocardite aguda
Acute kidney injury
Acute myocarditis
RAAS
Trypanosoma cruzi
dc.subject.en.pt_BR.fl_str_mv Acute kidney injury
Acute myocarditis
RAAS
Trypanosoma cruzi
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-06T15:35:31Z
dc.date.available.fl_str_mv 2016-09-06T15:35:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHUMBINHO, Lucianne C. et al. Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality. Journal of Experimental and Integrative Medicine, v.2, n.3, p.199-206, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15702
dc.identifier.issn.pt_BR.fl_str_mv 1309-4572
dc.identifier.eissn.none.fl_str_mv 2146-3298
identifier_str_mv CHUMBINHO, Lucianne C. et al. Cardiorenal interaction during the acute phase of experimental Trypanosoma cruzi infection: the influence of aldosterone and the AT1 receptor on mortality. Journal of Experimental and Integrative Medicine, v.2, n.3, p.199-206, 2012.
1309-4572
2146-3298
url https://www.arca.fiocruz.br/handle/icict/15702
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv GESDAV- Foundation for Education, Health, Social Cooperation and Solidairty of the People of the Gulhane
publisher.none.fl_str_mv GESDAV- Foundation for Education, Health, Social Cooperation and Solidairty of the People of the Gulhane
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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