Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice

Detalhes bibliográficos
Autor(a) principal: Nogueira, Denise Silva
Data de Publicação: 2016
Outros Autores: Guimarães, Pedro Henrique Gazzinelli, Barbosa, Fernando Sérgio, Resende, Nathália Maria, Silva, Caroline Cavalcanti, Oliveira, Luciana Maria de, Amorim, Chiara Cássia Oliveira, Oliveira, Fabrício Marcus Silva, Mattos, Matheus Silvério, Kraemer, Lucas Rocha, Caliari, Marcelo Vidigal, Jangola, Soraya Torres Gaze, Bueno, Lilian Lacerda, Russo, Remo de Castro, Fujiwara, Ricardo Toshio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16903
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, Brasil
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spelling Nogueira, Denise SilvaGuimarães, Pedro Henrique GazzinelliBarbosa, Fernando SérgioResende, Nathália MariaSilva, Caroline CavalcantiOliveira, Luciana Maria deAmorim, Chiara Cássia OliveiraOliveira, Fabrício Marcus SilvaMattos, Matheus SilvérioKraemer, Lucas RochaCaliari, Marcelo VidigalJangola, Soraya Torres GazeBueno, Lilian LacerdaRusso, Remo de CastroFujiwara, Ricardo Toshio2017-01-20T17:32:40Z2017-01-20T17:32:40Z2016NOGUEIRA, Denise Silva et al. Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice. PLoS Negl Trop Dis., vol. 10, n. 1, p. e0004382.1935-2735https://www.arca.fiocruz.br/handle/icict/1690310.1371/journal.pntd.0004382engPublic Library of SciencehelmintoseparasitologiaLung/parasitologyAscaris suum/physiologyMice, Inbred BALB C Th17 Cells/immunologyTh2 Cells/immunologyMultiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, Brasil/Universidade Federal do Mato Grosso. Instituto de Biologia e Ciencia da Saude. Cuiabá, MT, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Patologia Geral. Instituto de Ciencias Biologicas. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Fisiologia e Biofisica Laboratorio de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Fisiologia e Biofisica Laboratorio de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Patologia Geral. Instituto de Ciencias Biologicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, Brasil/University of Nottingham. United KingdomUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Fisiologia e Biofisica Laboratorio de Imunologia e Mecânica Pulmonar. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, Brasil/Universidade Federal do Mato Grosso. Instituto de Biologia e Ciencia da Saude. Cuiabá, MT, BrasilAscaris spp. infection affects 800 million people worldwide, and half of the world population is currently at risk of infection. Recurrent reinfection in humans is mostly due to the simplicity of the parasite life cycle, but the impact of multiple exposures to the biology of the infection and the consequences to the host's homeostasis are poorly understood. In this context, single and multiple exposures in mice were performed in order to characterize the parasitological, histopathological, tissue functional and immunological aspects of experimental larval ascariasis. The most important findings revealed that reinfected mice presented a significant reduction of parasite burden in the lung and an increase in the cellularity in the bronchoalveolar lavage (BAL) associated with a robust granulocytic pulmonary inflammation, leading to a severe impairment of respiratory function. Moreover, the multiple exposures to Ascaris elicited an increased number of circulating inflammatory cells as well as production of higher levels of systemic cytokines, mainly IL-4, IL-5, IL-6, IL-10, IL-17A and TNF-α when compared to single-infected animals. Taken together, our results suggest the intense pulmonary inflammation associated with a polarized systemic Th2/Th17 immune response are crucial to control larval migration after multiple exposures to Ascaris.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16903/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Nogueira_Denise_Multiple Exposures_CPqRR_2016.pdfve_Nogueira_Denise_Multiple Exposures_CPqRR_2016.pdfapplication/pdf7283772https://www.arca.fiocruz.br/bitstream/icict/16903/2/ve_Nogueira_Denise_Multiple%20Exposures_CPqRR_2016.pdf9287d516a1c1fa65a4453682a7bd231fMD52TEXTve_Nogueira_Denise_Multiple Exposures_CPqRR_2016.pdf.txtve_Nogueira_Denise_Multiple Exposures_CPqRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
title Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
spellingShingle Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
Nogueira, Denise Silva
helmintose
parasitologia
Lung/parasitology
Ascaris suum/physiology
Mice, Inbred BALB C Th17 Cells/immunology
Th2 Cells/immunology
title_short Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
title_full Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
title_fullStr Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
title_full_unstemmed Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
title_sort Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice
author Nogueira, Denise Silva
author_facet Nogueira, Denise Silva
Guimarães, Pedro Henrique Gazzinelli
Barbosa, Fernando Sérgio
Resende, Nathália Maria
Silva, Caroline Cavalcanti
Oliveira, Luciana Maria de
Amorim, Chiara Cássia Oliveira
Oliveira, Fabrício Marcus Silva
Mattos, Matheus Silvério
Kraemer, Lucas Rocha
Caliari, Marcelo Vidigal
Jangola, Soraya Torres Gaze
Bueno, Lilian Lacerda
Russo, Remo de Castro
Fujiwara, Ricardo Toshio
author_role author
author2 Guimarães, Pedro Henrique Gazzinelli
Barbosa, Fernando Sérgio
Resende, Nathália Maria
Silva, Caroline Cavalcanti
Oliveira, Luciana Maria de
Amorim, Chiara Cássia Oliveira
Oliveira, Fabrício Marcus Silva
Mattos, Matheus Silvério
Kraemer, Lucas Rocha
Caliari, Marcelo Vidigal
Jangola, Soraya Torres Gaze
Bueno, Lilian Lacerda
Russo, Remo de Castro
Fujiwara, Ricardo Toshio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nogueira, Denise Silva
Guimarães, Pedro Henrique Gazzinelli
Barbosa, Fernando Sérgio
Resende, Nathália Maria
Silva, Caroline Cavalcanti
Oliveira, Luciana Maria de
Amorim, Chiara Cássia Oliveira
Oliveira, Fabrício Marcus Silva
Mattos, Matheus Silvério
Kraemer, Lucas Rocha
Caliari, Marcelo Vidigal
Jangola, Soraya Torres Gaze
Bueno, Lilian Lacerda
Russo, Remo de Castro
Fujiwara, Ricardo Toshio
dc.subject.other.pt_BR.fl_str_mv helmintose
parasitologia
topic helmintose
parasitologia
Lung/parasitology
Ascaris suum/physiology
Mice, Inbred BALB C Th17 Cells/immunology
Th2 Cells/immunology
dc.subject.en.pt_BR.fl_str_mv Lung/parasitology
Ascaris suum/physiology
Mice, Inbred BALB C Th17 Cells/immunology
Th2 Cells/immunology
description Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia. Laboratorio de Imunologia e Genomica de Parasitos. Belo Horizonte, MG, Brasil
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-01-20T17:32:40Z
dc.date.available.fl_str_mv 2017-01-20T17:32:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NOGUEIRA, Denise Silva et al. Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice. PLoS Negl Trop Dis., vol. 10, n. 1, p. e0004382.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16903
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0004382
identifier_str_mv NOGUEIRA, Denise Silva et al. Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice. PLoS Negl Trop Dis., vol. 10, n. 1, p. e0004382.
1935-2735
10.1371/journal.pntd.0004382
url https://www.arca.fiocruz.br/handle/icict/16903
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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