Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2002 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40907 |
Resumo: | Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/168/8/4112.full.pdf |
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Silva, Adriana R.Assis, Edson F. deCaiado, Lara F. C.Marathe, Gopal K.Bozza, Marcelo T.McIntyre, Thomas M.Zimmerman, Guy A.Prescott, Stephen M.Bozza, Patrícia T.Faria Neto, Hugo Caire C.2020-04-21T16:27:46Z2020-04-21T16:27:46Z2002SILVA, Adriana R. et al. Monocyte Chemoattractant Protein-1 and 5-Lipoxygenase Products Recruit Leukocytes in Response to Platelet-Activating Factor-Like Lipids in Oxidized Low-Density Lipoprotein. Journal of Immunology, v. 168, p. 4112-4120, 2002.0022-1767https://www.arca.fiocruz.br/handle/icict/4090710.4049/jimmunol.168.8.41121550-6606Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/168/8/4112.full.pdfFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Laboratório Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil / University of Utah. Department of Pathology. Salt Lake City, UT, USA.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Laboratório Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Laboratório Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil / University of Utah. Department of Pathology. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA.University of Utah. Department of Internal Medicine. Salt Lake City, UT, USA / University of Utah. Huntsman Cancer Institute. Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Oxidized low-density lipoprotein (LDL) contains inflammatory agents, including oxidatively fragmented phospholipids that activate the platelet-activating factor (PAF) receptor, but in vivo events caused by these pathologically generated agents are not well defined. Injection of PAF-like lipids derived from oxidized LDL, or C(4)-PAF that is a major PAF-like lipid in these particles, into the pleural cavity of mice resulted in rapid monocyte, neutrophil, and eosinophil accumulation. Increased numbers of intracellular lipid bodies in these cells show they were in an inflammatory environment. Leukocyte recruitment was abolished by a PAF receptor antagonist, as expected. PAF-like lipids induced 5-lipoxygenase expression in leukocytes, mRNA expression for monocyte chemoattractant protein-1 (MCP-1) and other chemokines, synthesis of MCP-1, and leukotriene B(4). The 5-lipoxygenase inhibitor zileuton impaired neutrophil influx, while MCP-1 had a more global role, as determined with MCP-1(-/-) mice. The lack of MCP-1 abrogated leukocyte accumulation and lipid body formation both in vivo and in vitro and chemokine transcription in vivo, and reduced in vivo leukotriene B(4) production. Thus, PAF-like phospholipids in oxidized LDL induce an inflammatory infiltrate through the PAF receptor, chemokine transcription, lipid body formation, and 5-lipoxygenase expression in leukocytes. MCP-1 has a key role in this inflammatory response, and 5-lipoxygenase products are essential for neutrophil recruitment into the inflamed pleural cavity.engAmerican Association of ImmunologistsMonocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoproteininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMonocyte Chemoattractant Protein-15-Lipoxygenase Products Recruit LeukocytesPlatelet-Activating Factor-Like LipidsOxidized low-density lipoprotein (LDL)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| title |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| spellingShingle |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein Silva, Adriana R. Monocyte Chemoattractant Protein-1 5-Lipoxygenase Products Recruit Leukocytes Platelet-Activating Factor-Like Lipids Oxidized low-density lipoprotein (LDL) |
| title_short |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| title_full |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| title_fullStr |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| title_full_unstemmed |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| title_sort |
Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein |
| author |
Silva, Adriana R. |
| author_facet |
Silva, Adriana R. Assis, Edson F. de Caiado, Lara F. C. Marathe, Gopal K. Bozza, Marcelo T. McIntyre, Thomas M. Zimmerman, Guy A. Prescott, Stephen M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
| author_role |
author |
| author2 |
Assis, Edson F. de Caiado, Lara F. C. Marathe, Gopal K. Bozza, Marcelo T. McIntyre, Thomas M. Zimmerman, Guy A. Prescott, Stephen M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Adriana R. Assis, Edson F. de Caiado, Lara F. C. Marathe, Gopal K. Bozza, Marcelo T. McIntyre, Thomas M. Zimmerman, Guy A. Prescott, Stephen M. Bozza, Patrícia T. Faria Neto, Hugo Caire C. |
| dc.subject.en.pt_BR.fl_str_mv |
Monocyte Chemoattractant Protein-1 5-Lipoxygenase Products Recruit Leukocytes Platelet-Activating Factor-Like Lipids Oxidized low-density lipoprotein (LDL) |
| topic |
Monocyte Chemoattractant Protein-1 5-Lipoxygenase Products Recruit Leukocytes Platelet-Activating Factor-Like Lipids Oxidized low-density lipoprotein (LDL) |
| description |
Acesso aberto em 21/04/2020 - https://www.jimmunol.org/content/jimmunol/168/8/4112.full.pdf |
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2002 |
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2002 |
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2020-04-21T16:27:46Z |
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2020-04-21T16:27:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, Adriana R. et al. Monocyte Chemoattractant Protein-1 and 5-Lipoxygenase Products Recruit Leukocytes in Response to Platelet-Activating Factor-Like Lipids in Oxidized Low-Density Lipoprotein. Journal of Immunology, v. 168, p. 4112-4120, 2002. |
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https://www.arca.fiocruz.br/handle/icict/40907 |
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0022-1767 |
| dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.168.8.4112 |
| dc.identifier.eissn.none.fl_str_mv |
1550-6606 |
| identifier_str_mv |
SILVA, Adriana R. et al. Monocyte Chemoattractant Protein-1 and 5-Lipoxygenase Products Recruit Leukocytes in Response to Platelet-Activating Factor-Like Lipids in Oxidized Low-Density Lipoprotein. Journal of Immunology, v. 168, p. 4112-4120, 2002. 0022-1767 10.4049/jimmunol.168.8.4112 1550-6606 |
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American Association of Immunologists |
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American Association of Immunologists |
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