Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil

Detalhes bibliográficos
Autor(a) principal: Monachesi, Clarisse Fonseca
Data de Publicação: 2023
Outros Autores: Gomes-Silva, Adriano, Carvalho-Costa, Filipe Anibal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/61015
Resumo: This work was supported by the federal funds allocated to the Laboratory of Molecular Epidemiology and Systematics of the Oswaldo Cruz Institute – Fiocruz (Annual Plan of Objectives and Goals).
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spelling Monachesi, Clarisse FonsecaGomes-Silva, AdrianoCarvalho-Costa, Filipe Anibal2023-11-02T00:37:44Z2023-11-02T00:37:44Z2023MONACHESI, Clarisse Fonseca; GOMES-SILVA, Adriano; CARVALHO-COSTA, Filipe Anibal. Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil. Revista do Instituto de Medicina Tropical de São Paulo, V. 65, p. 1-10, 2023.1678-9946https://www.arca.fiocruz.br/handle/icict/6101510.1590/S1678-9946202365047This work was supported by the federal funds allocated to the Laboratory of Molecular Epidemiology and Systematics of the Oswaldo Cruz Institute – Fiocruz (Annual Plan of Objectives and Goals).Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brazil.This study aimed to assess the factors associated with mucosal leishmaniasis (ML) within the scope of tegumentary leishmaniasis (TL) cases reported in Brazil. Surveillance data were assessed, and comparisons were made between ML and cutaneous leishmaniasis (CL) cases. Additionally, ML incidence rates for municipalities were depicted through a geographic information system. From 2007 to 2017, 235,489 TL cases were reported, of which 235,232 were classified as follows: 14,204 (6%) were ML cases and 221,028 (94%) were CL cases. Multivariate analysis showed that the proportion of ML cases reached 16.8% among individuals >75 years (adjusted OR = 2.77; 95% CI = 2.41-3.19; p < 0.001), and ML was also more frequent among males (aOR = 1.28; 95% CI = 1.20-1.38; p < 0.001), HIV-positive patients (aOR = 2.15; 95% CI = 1.80-2.56; p < 0.001), patients residing in urban areas (aOR = 1.52; 95% CI = 1.43-1.62; p < 0.001), and imported cases (with respect to county) when compared to autochthonous cases (aOR = 1.84; 95% CI = 1.71-1.98; p < 0.001). A lower proportion of positive results in direct parasitological examinations was observed in ML cases (32.6% vs. 60.8%; p < 0.001). The leishmanin skin test results were more often positive in ML cases (41.7% vs. 25.9%; p < 0.001). In ML, compatible changes in histopathology were more frequent (14.6% vs. 3.9%; p < 0.001). A greater proportion of ML cases were treated with amphotericin B (6.9% vs. 0.9%; p < 0.001). The case-fatality rate was higher in ML (0.6% vs. 0.1%; p < 0.001). A higher incidence of ML was observed in a geographical band extending across the Amazon region from the southern Para State to the Acre State. ML exhibited varying frequencies within specific populations. The definition of predictable factors predisposing Leishmania-infected subjects to develop ML is important for defining strategies to mitigate the mucosal damage caused by leishmaniasis.engInstituto de Medicina Tropical de São PauloFactors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCutaneous leishmaniasisMucosal leishmaniasisBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
title Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
spellingShingle Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
Monachesi, Clarisse Fonseca
Cutaneous leishmaniasis
Mucosal leishmaniasis
Brazil
title_short Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
title_full Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
title_fullStr Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
title_full_unstemmed Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
title_sort Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil
author Monachesi, Clarisse Fonseca
author_facet Monachesi, Clarisse Fonseca
Gomes-Silva, Adriano
Carvalho-Costa, Filipe Anibal
author_role author
author2 Gomes-Silva, Adriano
Carvalho-Costa, Filipe Anibal
author2_role author
author
dc.contributor.author.fl_str_mv Monachesi, Clarisse Fonseca
Gomes-Silva, Adriano
Carvalho-Costa, Filipe Anibal
dc.subject.en.en_US.fl_str_mv Cutaneous leishmaniasis
Mucosal leishmaniasis
Brazil
topic Cutaneous leishmaniasis
Mucosal leishmaniasis
Brazil
description This work was supported by the federal funds allocated to the Laboratory of Molecular Epidemiology and Systematics of the Oswaldo Cruz Institute – Fiocruz (Annual Plan of Objectives and Goals).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-11-02T00:37:44Z
dc.date.available.fl_str_mv 2023-11-02T00:37:44Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MONACHESI, Clarisse Fonseca; GOMES-SILVA, Adriano; CARVALHO-COSTA, Filipe Anibal. Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil. Revista do Instituto de Medicina Tropical de São Paulo, V. 65, p. 1-10, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/61015
dc.identifier.issn.en_US.fl_str_mv 1678-9946
dc.identifier.doi.none.fl_str_mv 10.1590/S1678-9946202365047
identifier_str_mv MONACHESI, Clarisse Fonseca; GOMES-SILVA, Adriano; CARVALHO-COSTA, Filipe Anibal. Factors associated with mucosal involvement in tegumentary leishmaniasis: a nation-based study using surveillance data from Brazil. Revista do Instituto de Medicina Tropical de São Paulo, V. 65, p. 1-10, 2023.
1678-9946
10.1590/S1678-9946202365047
url https://www.arca.fiocruz.br/handle/icict/61015
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/61015/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/61015/2/ve_Clarisse_Monachesi_etal_INI_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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