Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research

Detalhes bibliográficos
Autor(a) principal: Oliveira, Rodrigo Corrêa
Data de Publicação: 2009
Outros Autores: Scharfstein, Julio, Gomes, Juliana de Assis Silva, Oliveira, Rodrigo Correa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02762009000900025
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58453
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil
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spelling Oliveira, Rodrigo CorrêaScharfstein, JulioGomes, Juliana de Assis SilvaOliveira, Rodrigo Correa2023-05-17T12:27:21Z2023-05-17T12:27:21Z2009SCHARFSTEIN, Julio; GOMES, Juliana de Assis Silva; OLIVEIRA, Rodrigo Correa . Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research. Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, 187-198, 2009. doi.org/10.1590/S0074-027620090009000250074-0276https://www.arca.fiocruz.br/handle/icict/5845310.1590/S0074-02762009000900025engMinistério da SaúdeBack to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, BrasilDespite the wealth of information generated by trans-disciplinary research in Chagas disease, knowledge about its multifaceted pathogenesis is still fragmented. Here we review the body of experimental studies in animal models supporting the concept that persistent infection by Trypanosoma cruzi is crucial for the development of chronic myocarditis. Complementing this review, we will make an effort to reconcile seemingly contradictory results concerning the immune profiles of chronic patients from Argentina and Brazil. Finally, we will review the results of molecular studies suggesting that parasite-induced inflammation and tissue damage is, at least in part, mediated by the activities of trans-sialidase, mucin-linked lipid anchors (TLR2 ligand) and cruzipain (a kinin-releasing cysteine protease). One hundred years after the discovery of Chagas disease, it is reassuring that basic and clinical research tends to converge, raising new perspectives for the treatment of chronic Chagas diseaseFundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, BrasilChagas diseaseT cellsTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALback to the future.pdfback to the future.pdfapplication/pdf343714https://www.arca.fiocruz.br/bitstream/icict/58453/2/back%20to%20the%20future.pdf1635ca5aa73ef6e6d0343172326f0de3MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58453/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584532023-05-17 09:27:21.894oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-17T12:27:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
title Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
spellingShingle Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
Oliveira, Rodrigo Corrêa
Fundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
Chagas disease
T cells
Trypanosoma cruzi
title_short Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
title_full Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
title_fullStr Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
title_full_unstemmed Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
title_sort Back to the future in Chagas disease: From animal models to patient cohort studies, progress in immunopathogenesis research
author Oliveira, Rodrigo Corrêa
author_facet Oliveira, Rodrigo Corrêa
Scharfstein, Julio
Gomes, Juliana de Assis Silva
Oliveira, Rodrigo Correa
author_role author
author2 Scharfstein, Julio
Gomes, Juliana de Assis Silva
Oliveira, Rodrigo Correa
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Rodrigo Corrêa
Scharfstein, Julio
Gomes, Juliana de Assis Silva
Oliveira, Rodrigo Correa
dc.subject.en.en_US.fl_str_mv Fundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
Chagas disease
T cells
Trypanosoma cruzi
topic Fundação Oswaldo Cruz. Instituto de Pesquisa René Rachou. Belo Horizonte, MG, Brasil
Chagas disease
T cells
Trypanosoma cruzi
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2023-05-17T12:27:21Z
dc.date.available.fl_str_mv 2023-05-17T12:27:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHARFSTEIN, Julio; GOMES, Juliana de Assis Silva; OLIVEIRA, Rodrigo Correa . Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research. Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, 187-198, 2009. doi.org/10.1590/S0074-02762009000900025
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58453
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762009000900025
identifier_str_mv SCHARFSTEIN, Julio; GOMES, Juliana de Assis Silva; OLIVEIRA, Rodrigo Correa . Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research. Mem. Inst. Oswaldo Cruz, v. 104, suppl 1, 187-198, 2009. doi.org/10.1590/S0074-02762009000900025
0074-0276
10.1590/S0074-02762009000900025
url https://www.arca.fiocruz.br/handle/icict/58453
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ministério da Saúde
publisher.none.fl_str_mv Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58453/2/back%20to%20the%20future.pdf
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