Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno de Bezerril
Data de Publicação: 2013
Outros Autores: Hullsiek, Katherine Huppler, Boulware, David R, Rupert, Adam, French, Martyn A, Ruxrungtham, Kiat, Montes, Marisa Luisa, Price, Huw, Barreiro, Pablo, Audsley, Jennifer, Sher, Alan, Lewin, Sharon R, Sereti, Irini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24875
Resumo: ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.documento”.
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spelling Andrade, Bruno de BezerrilHullsiek, Katherine HupplerBoulware, David RRupert, AdamFrench, Martyn ARuxrungtham, KiatMontes, Marisa LuisaPrice, HuwBarreiro, PabloAudsley, JenniferSher, AlanLewin, Sharon RSereti, Irini2018-02-20T12:34:27Z2018-02-20T12:34:27Z2013ANDRADE, B.B. et al. Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. The Journal of Infectious Diseases, v. 207, p. 1379–1388, 2013.0022-1899https://www.arca.fiocruz.br/handle/icict/2487510.1093/infdis/jit033ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.documento”.National Institute of Allergy and Infectious Diseases (NIAID; grants 3 U01 AI068641-05S1, U01AI042170, and U01AI046362) and the NIAID Intramural Research Program, National Institutes of Health; the National Research University Project of CHE and the Ratchadaphiseksomphot Endowment Fund, Thailand (grant HR1161A to K. R.); the National Science and Technology Development Agency, BIOTEC (grant to K. R.); and the Thai Research Fund, Thailand (to K. R.).National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MDUniversity of Minnesota. Minneapolis, MN, EUAUniversity of Minnesota. Minneapolis, MN, EUANational Cancer Institute. SAIC Frederick. Frederick, MD, EUAUniversity of Western Australia. Perth, AustraliaChulalongkorn University. Faculty of Medicine. Bangkok Thailand / Thai Red Cross AIDS Research Center. Bangkok ThailandHospital La Paz. Madrid, SpainClinical Trials Unit. London, United KingdomHospital Carlos III. Madrid, SpainThe Alfred Hospital. Melbourne, Australia / Monash University. Melbourne, AustraliaNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USAThe Alfred Hospital. Melbourne, Australia / Monash University. Melbourne, Australia / Burnet Institute. Melbourne, AustraliaNational Institute of Allergy Infectious Diseases. National Institutes of Health. Clinical and Molecular Retrovirology Section. Laboratory of Immunoregulation. Bethesda, MDHepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDSdefining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher D-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in univariate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.engOxford University PressVírus da hepatiteBiomarcadoresAIDSHepatiteHepatic flaresBiomarkersAIDSHepatitisBiomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis virusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24875/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndrade BB Biomarkers of inflammation.....pdfAndrade BB Biomarkers of 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dc.title.pt_BR.fl_str_mv Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
title Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
spellingShingle Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
Andrade, Bruno de Bezerril
Vírus da hepatite
Biomarcadores
AIDS
Hepatite
Hepatic flares
Biomarkers
AIDS
Hepatitis
title_short Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
title_full Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
title_fullStr Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
title_full_unstemmed Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
title_sort Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses
author Andrade, Bruno de Bezerril
author_facet Andrade, Bruno de Bezerril
Hullsiek, Katherine Huppler
Boulware, David R
Rupert, Adam
French, Martyn A
Ruxrungtham, Kiat
Montes, Marisa Luisa
Price, Huw
Barreiro, Pablo
Audsley, Jennifer
Sher, Alan
Lewin, Sharon R
Sereti, Irini
author_role author
author2 Hullsiek, Katherine Huppler
Boulware, David R
Rupert, Adam
French, Martyn A
Ruxrungtham, Kiat
Montes, Marisa Luisa
Price, Huw
Barreiro, Pablo
Audsley, Jennifer
Sher, Alan
Lewin, Sharon R
Sereti, Irini
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno de Bezerril
Hullsiek, Katherine Huppler
Boulware, David R
Rupert, Adam
French, Martyn A
Ruxrungtham, Kiat
Montes, Marisa Luisa
Price, Huw
Barreiro, Pablo
Audsley, Jennifer
Sher, Alan
Lewin, Sharon R
Sereti, Irini
dc.subject.other.pt_BR.fl_str_mv Vírus da hepatite
Biomarcadores
AIDS
Hepatite
topic Vírus da hepatite
Biomarcadores
AIDS
Hepatite
Hepatic flares
Biomarkers
AIDS
Hepatitis
dc.subject.en.pt_BR.fl_str_mv Hepatic flares
Biomarkers
AIDS
Hepatitis
description ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-02-20T12:34:27Z
dc.date.available.fl_str_mv 2018-02-20T12:34:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, B.B. et al. Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. The Journal of Infectious Diseases, v. 207, p. 1379–1388, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24875
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jit033
identifier_str_mv ANDRADE, B.B. et al. Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. The Journal of Infectious Diseases, v. 207, p. 1379–1388, 2013.
0022-1899
10.1093/infdis/jit033
url https://www.arca.fiocruz.br/handle/icict/24875
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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