The central role of Fas-ligand cell signaling in inflammatory lung diseases.

Detalhes bibliográficos
Autor(a) principal: DosReis, George Alexandre
Data de Publicação: 2004
Outros Autores: Borges, Valeria de Matos, Zin, Walter Araujo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9472
Resumo: Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
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spelling DosReis, George AlexandreBorges, Valeria de MatosZin, Walter Araujo2015-02-10T14:22:32Z2015-02-10T14:22:32Z2004DosREIS, G. A.; BORGES, V. M.; ZIN, W. A. The central role of Fas-ligand cell signaling in inflammatory lung diseases. Journal of Cellular and Molecular Medicina, v. 8, n. 3, p. 285-293, 2004.1582-1838https://www.arca.fiocruz.br/handle/icict/9472engopen accessThe central role of Fas-ligand cell signaling in inflammatory lung diseases.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFollowing inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1 beta and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas-FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseasesFas ligandApoptosisInflammationNeutrophilMacrophagePhagocytosisFibrosisLungInjurySilicosisAntígenos CD95/imunologiaGlicoproteínas de Membrana/fisiologiaPneumonia/imunologiaDoença AgudaApoptoseCélulas Epiteliais/metabolismoProteína Ligante FasRegulação da Expressão GênicaHumanosInterleucina-1/metabolismoMacrófagos Alveolares/imunologiaNeutrófilos/imunologiaPneumonia/metabolismoAlvéolos Pulmonares/imunologiaFibrose Pulmonar/imunologiaTransdução de SinalSilicose/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTHUMBNAILDosReis GA The central...pdf.jpgDosReis GA The central...pdf.jpgGenerated Thumbnailimage/jpeg1531https://www.arca.fiocruz.br/bitstream/icict/9472/4/DosReis%20GA%20The%20central...pdf.jpg74eff2014a6f5538872b8857c8089dd4MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9472/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALDosReis GA The central...pdfDosReis GA The central...pdfapplication/pdf1398350https://www.arca.fiocruz.br/bitstream/icict/9472/2/DosReis%20GA%20The%20central...pdf38fc272d7e226f14c4c4eb70ec8b5764MD52TEXTDosReis GA The central...pdf.txtDosReis GA The central...pdf.txtExtracted texttext/plain34522https://www.arca.fiocruz.br/bitstream/icict/9472/3/DosReis%20GA%20The%20central...pdf.txtb679414363cf14293021d5ff139304e0MD53icict/94722023-03-15 14:32:47.513oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The central role of Fas-ligand cell signaling in inflammatory lung diseases.
title The central role of Fas-ligand cell signaling in inflammatory lung diseases.
spellingShingle The central role of Fas-ligand cell signaling in inflammatory lung diseases.
DosReis, George Alexandre
Fas ligand
Apoptosis
Inflammation
Neutrophil
Macrophage
Phagocytosis
Fibrosis
Lung
Injury
Silicosis
Antígenos CD95/imunologia
Glicoproteínas de Membrana/fisiologia
Pneumonia/imunologia
Doença Aguda
Apoptose
Células Epiteliais/metabolismo
Proteína Ligante Fas
Regulação da Expressão Gênica
Humanos
Interleucina-1/metabolismo
Macrófagos Alveolares/imunologia
Neutrófilos/imunologia
Pneumonia/metabolismo
Alvéolos Pulmonares/imunologia
Fibrose Pulmonar/imunologia
Transdução de Sinal
Silicose/imunologia
title_short The central role of Fas-ligand cell signaling in inflammatory lung diseases.
title_full The central role of Fas-ligand cell signaling in inflammatory lung diseases.
title_fullStr The central role of Fas-ligand cell signaling in inflammatory lung diseases.
title_full_unstemmed The central role of Fas-ligand cell signaling in inflammatory lung diseases.
title_sort The central role of Fas-ligand cell signaling in inflammatory lung diseases.
author DosReis, George Alexandre
author_facet DosReis, George Alexandre
Borges, Valeria de Matos
Zin, Walter Araujo
author_role author
author2 Borges, Valeria de Matos
Zin, Walter Araujo
author2_role author
author
dc.contributor.author.fl_str_mv DosReis, George Alexandre
Borges, Valeria de Matos
Zin, Walter Araujo
dc.subject.en.pt_BR.fl_str_mv Fas ligand
Apoptosis
Inflammation
Neutrophil
Macrophage
Phagocytosis
Fibrosis
Lung
Injury
Silicosis
topic Fas ligand
Apoptosis
Inflammation
Neutrophil
Macrophage
Phagocytosis
Fibrosis
Lung
Injury
Silicosis
Antígenos CD95/imunologia
Glicoproteínas de Membrana/fisiologia
Pneumonia/imunologia
Doença Aguda
Apoptose
Células Epiteliais/metabolismo
Proteína Ligante Fas
Regulação da Expressão Gênica
Humanos
Interleucina-1/metabolismo
Macrófagos Alveolares/imunologia
Neutrófilos/imunologia
Pneumonia/metabolismo
Alvéolos Pulmonares/imunologia
Fibrose Pulmonar/imunologia
Transdução de Sinal
Silicose/imunologia
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD95/imunologia
Glicoproteínas de Membrana/fisiologia
Pneumonia/imunologia
Doença Aguda
Apoptose
Células Epiteliais/metabolismo
Proteína Ligante Fas
Regulação da Expressão Gênica
Humanos
Interleucina-1/metabolismo
Macrófagos Alveolares/imunologia
Neutrófilos/imunologia
Pneumonia/metabolismo
Alvéolos Pulmonares/imunologia
Fibrose Pulmonar/imunologia
Transdução de Sinal
Silicose/imunologia
description Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2015-02-10T14:22:32Z
dc.date.available.fl_str_mv 2015-02-10T14:22:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv DosREIS, G. A.; BORGES, V. M.; ZIN, W. A. The central role of Fas-ligand cell signaling in inflammatory lung diseases. Journal of Cellular and Molecular Medicina, v. 8, n. 3, p. 285-293, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9472
dc.identifier.issn.none.fl_str_mv 1582-1838
identifier_str_mv DosREIS, G. A.; BORGES, V. M.; ZIN, W. A. The central role of Fas-ligand cell signaling in inflammatory lung diseases. Journal of Cellular and Molecular Medicina, v. 8, n. 3, p. 285-293, 2004.
1582-1838
url https://www.arca.fiocruz.br/handle/icict/9472
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