Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49147 |
Resumo: | National Institutes of Health (NIH U01 AI069923 and NIAID 1 P30AI110527-03) |
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Schleu, Minna FerrariDuarte, Beatriz BarretoArriaga Gutiérrez, María BelenPereira, Mariana AraujoLadeia, Ana Marice TeixeiraAndrade, Bruno de BezerrilLima, Maria L.2021-09-23T18:44:27Z2021-09-23T18:44:27Z2021SCHLEU, Minna Ferrari et al. Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women. Nutrients, v. 13, n. 9, p. 1-12, 27 Aug. 2021.2072-6643https://www.arca.fiocruz.br/handle/icict/4914710.3390/nu13092979National Institutes of Health (NIH U01 AI069923 and NIAID 1 P30AI110527-03)CCASAnet and RePORT-Brazil Tennessee Center for AIDS Research (TNCFAR)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance code: 001)Fundação de Amparo à Pesquisa da Bahia (FAPESB)Intramural Research Program of the Oswaldo Cruz Foundation (FIOCRUZ)National Council for Scientific and Technological Development (CNPq), BrazilEscola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Departamento de Clínica Médica. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Departamento de Clínica Médica. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Programa de Pós-Graduação em Medicina e Saúde Humana. Salvador, BA, Brasil.Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnosed with obesity, recruited between 2009 and 2013, in an obesity referral outpatient clinic in Bahia, Brazil. Laboratory and clinical characteristics were compared between the groups according to the degree of obesity (I, II and III), and levels of 25-hydroxyvitamin D [25(OH)D] were used to define the VITD status (insufficiency and no insufficiency). We calculated the homeostatic model assessment-IR (HOMA-IR) index to assess insulin resistance in the groups. Our analyses revealed that HOMA-IR values and VITD levels were inversely correlated. Furthermore, we observed a distinct expression profile of values of laboratory markers according to 25(OH)D levels. Negative correlations were found between HOMA-IR and body mass index (BMI) in VITD insufficient participants but not in those with the sufficiency. Furthermore, multivariate regression demonstrated independent associations between lower levels of 25(OH)D and increased values of HOMA-IR. These findings suggests that lower levels of VITD are strongly associated with the increased IR in obese women.engMDPIVitamina DObesidadeMulheresResistência a insulinaÍndice de massa corporalVitamin DObesityWomenInsulin resistanceHOMA-IRLower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49147/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSchleu, Minna F. Lower levels....pdfSchleu, Minna F. Lower levels....pdfapplication/pdf3060178https://www.arca.fiocruz.br/bitstream/icict/49147/2/Schleu%2c%20Minna%20F.%20Lower%20levels....pdfef502484a14a2b608945746be7a238a2MD52icict/491472023-03-15 14:34:25.244oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| title |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| spellingShingle |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women Schleu, Minna Ferrari Vitamina D Obesidade Mulheres Resistência a insulina Índice de massa corporal Vitamin D Obesity Women Insulin resistance HOMA-IR |
| title_short |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| title_full |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| title_fullStr |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| title_full_unstemmed |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| title_sort |
Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women |
| author |
Schleu, Minna Ferrari |
| author_facet |
Schleu, Minna Ferrari Duarte, Beatriz Barreto Arriaga Gutiérrez, María Belen Pereira, Mariana Araujo Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril Lima, Maria L. |
| author_role |
author |
| author2 |
Duarte, Beatriz Barreto Arriaga Gutiérrez, María Belen Pereira, Mariana Araujo Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril Lima, Maria L. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Schleu, Minna Ferrari Duarte, Beatriz Barreto Arriaga Gutiérrez, María Belen Pereira, Mariana Araujo Ladeia, Ana Marice Teixeira Andrade, Bruno de Bezerril Lima, Maria L. |
| dc.subject.other.pt_BR.fl_str_mv |
Vitamina D Obesidade Mulheres Resistência a insulina Índice de massa corporal |
| topic |
Vitamina D Obesidade Mulheres Resistência a insulina Índice de massa corporal Vitamin D Obesity Women Insulin resistance HOMA-IR |
| dc.subject.en.en.fl_str_mv |
Vitamin D Obesity Women Insulin resistance HOMA-IR |
| description |
National Institutes of Health (NIH U01 AI069923 and NIAID 1 P30AI110527-03) |
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2021 |
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2021-09-23T18:44:27Z |
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2021-09-23T18:44:27Z |
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2021 |
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info:eu-repo/semantics/article |
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SCHLEU, Minna Ferrari et al. Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women. Nutrients, v. 13, n. 9, p. 1-12, 27 Aug. 2021. |
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https://www.arca.fiocruz.br/handle/icict/49147 |
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2072-6643 |
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10.3390/nu13092979 |
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SCHLEU, Minna Ferrari et al. Lower levels of vitamin D are associated with an increase in insulin resistance in obese brazilian women. Nutrients, v. 13, n. 9, p. 1-12, 27 Aug. 2021. 2072-6643 10.3390/nu13092979 |
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