Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26259 |
Resumo: | Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / Universidade Federal do Paraná. Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil. |
| id |
CRUZ_30ec3cf1cad63f464bd37c6b44d6a0f7 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/26259 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Vicente, Vania AparecidaWeiss, Vinícius A.Bombassaro, AmandaMoreno, Leandro F.Costa, Flávia F.Raittz, Roberto T.Leão, Aniele C. RibasGomes, Renata R.Bocca, Anamelia L.Fornari, GhenifferCastro, Raffael J. A. deSun, JiufengFaoro, HelissonTadra-Sfeir, Michelle ZibettiBaura, ValterBalsanelli, EduardoAlmeida, Sandro R.Santos, Suelen S. dosTeixeira, Marcus de MeloFelipe, Maria S. SoaresNascimento, Mariana Machado Fidelis doPedrosa, Fábio OliveiraSteffens, Maria Berenice R.Attili-Angelis, DerleneNajafzadeh, Mohammad JavadQueiroz-Telles, FlávioSouza, Emanuel Maltempi deHoog, Sybren de2018-05-03T19:30:23Z2018-05-03T19:30:23Z2017VICENTE, Vânia A. et al. Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis. Frontiers in Microbiology, v. 8, n. 1924, p. 1-20, 2017.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2625910.3389/fmicb.2017.01924porFrontiers MediaFonsecaeaGenomicsChromoblastomycosisFungiGenómicaCromoblastomicosisHongosGenômicaCromoblastomicoseFungosComparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / Universidade Federal do Paraná. Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Setor de Educação Profissional e Tecnológica. Laboratório de Bioinformática. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / CBS-KNAW Fungal Biodiversity Centre. Utrecht, Netherlands / University of Amsterdam. Institute for Biodiversity and Ecosystem Dynamics. Amsterdam, Netherlands.Universidade Federal do Paraná. Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Setor de Educação Profissional e Tecnológica. Laboratório de Bioinformática. Curitiba, PR, Brasil.Universidade Federal do Paraná. Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil / Universidade Federal do Paraná. Setor de Educação Profissional e Tecnológica. Laboratório de Bioinformática. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Brasilia, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Brasilia, Brasil.Guangdong Provincial Center for Disease Control and Prevention. Guangdong Provincial Institute of Public Health, Guangzhou, China.Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Brasilia, Brasil / Northern Arizona University. Pathogen and Microbiome Institute. Flagstaff, United States.Universidade Católica de Brasília. Departamento de Ciências Genômicas e Biotecnologia. Brasília, DF, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Setor de Educação Profissional e Tecnológica. Laboratório de Bioinformática. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade de Campinas. Divisão de Recursos Microbianos. Campinas, SP, Brasil.Mashhad University of Medical Sciences. School of Medicine. Department of Parasitology and Mycology. Mashhad, Iran.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / Universidade Federal do Paraná. Hospital das Clínicas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Setor de Educação Profissional e Tecnológica. Laboratório de Bioinformática. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Bioquímica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / CBS-KNAW Fungal Biodiversity Centre. Utrecht, Netherlands / University of Amsterdam. Institute for Biodiversity and Ecosystem Dynamics. Amsterdam, Netherlands.Fonsecaea and Cladophialophora are genera of black yeast-like fungi harboring agents of a mutilating implantation disease in humans, along with strictly environmental species. The current hypothesis suggests that those species reside in somewhat adverse microhabitats, and pathogenic siblings share virulence factors enabling survival in mammal tissue after coincidental inoculation driven by pathogenic adaptation. A comparative genomic analysis of environmental and pathogenic siblings of Fonsecaea and Cladophialophora was undertaken, including de novo assembly of F. erecta from plant material. The genome size of Fonsecaea species varied between 33.39 and 35.23 Mb, and the core genomes of those species comprises almost 70% of the genes. Expansions of protein domains such as glyoxalases and peptidases suggested ability for pathogenicity in clinical agents, while the use of nitrogen and degradation of phenolic compounds was enriched in environmental species. The similarity of carbohydrate-active vs. protein-degrading enzymes associated with the occurrence of virulence factors suggested a general tolerance to extreme conditions, which might explain the opportunistic tendency of Fonsecaea sibling species. Virulence was tested in the Galleria mellonella model and immunological assays were performed in order to support this hypothesis. Larvae infected by environmental F. erecta had a lower survival. Fungal macrophage murine co-culture showed that F. erecta induced high levels of TNF-α contributing to macrophage activation that could increase the ability to control intracellular fungal growth although hyphal death were not observed, suggesting a higher level of extremotolerance of environmental species.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/26259/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALFaoroComparativ.pdfFaoroComparativ.pdfapplication/pdf5399928https://www.arca.fiocruz.br/bitstream/icict/26259/2/FaoroComparativ.pdfaf51deed6d3e60618950577e576e6aadMD52TEXTFaoroComparativ.pdf.txtFaoroComparativ.pdf.txtExtracted texttext/plain102713https://www.arca.fiocruz.br/bitstream/icict/26259/3/FaoroComparativ.pdf.txt06026655a31fdc682c97ec871b863324MD53icict/262592019-11-23 21:52:38.823oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-11-24T00:52:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| title |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| spellingShingle |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis Vicente, Vania Aparecida Fonsecaea Genomics Chromoblastomycosis Fungi Genómica Cromoblastomicosis Hongos Genômica Cromoblastomicose Fungos |
| title_short |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| title_full |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| title_fullStr |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| title_full_unstemmed |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| title_sort |
Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis |
| author |
Vicente, Vania Aparecida |
| author_facet |
Vicente, Vania Aparecida Weiss, Vinícius A. Bombassaro, Amanda Moreno, Leandro F. Costa, Flávia F. Raittz, Roberto T. Leão, Aniele C. Ribas Gomes, Renata R. Bocca, Anamelia L. Fornari, Gheniffer Castro, Raffael J. A. de Sun, Jiufeng Faoro, Helisson Tadra-Sfeir, Michelle Zibetti Baura, Valter Balsanelli, Eduardo Almeida, Sandro R. Santos, Suelen S. dos Teixeira, Marcus de Melo Felipe, Maria S. Soares Nascimento, Mariana Machado Fidelis do Pedrosa, Fábio Oliveira Steffens, Maria Berenice R. Attili-Angelis, Derlene Najafzadeh, Mohammad Javad Queiroz-Telles, Flávio Souza, Emanuel Maltempi de Hoog, Sybren de |
| author_role |
author |
| author2 |
Weiss, Vinícius A. Bombassaro, Amanda Moreno, Leandro F. Costa, Flávia F. Raittz, Roberto T. Leão, Aniele C. Ribas Gomes, Renata R. Bocca, Anamelia L. Fornari, Gheniffer Castro, Raffael J. A. de Sun, Jiufeng Faoro, Helisson Tadra-Sfeir, Michelle Zibetti Baura, Valter Balsanelli, Eduardo Almeida, Sandro R. Santos, Suelen S. dos Teixeira, Marcus de Melo Felipe, Maria S. Soares Nascimento, Mariana Machado Fidelis do Pedrosa, Fábio Oliveira Steffens, Maria Berenice R. Attili-Angelis, Derlene Najafzadeh, Mohammad Javad Queiroz-Telles, Flávio Souza, Emanuel Maltempi de Hoog, Sybren de |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vicente, Vania Aparecida Weiss, Vinícius A. Bombassaro, Amanda Moreno, Leandro F. Costa, Flávia F. Raittz, Roberto T. Leão, Aniele C. Ribas Gomes, Renata R. Bocca, Anamelia L. Fornari, Gheniffer Castro, Raffael J. A. de Sun, Jiufeng Faoro, Helisson Tadra-Sfeir, Michelle Zibetti Baura, Valter Balsanelli, Eduardo Almeida, Sandro R. Santos, Suelen S. dos Teixeira, Marcus de Melo Felipe, Maria S. Soares Nascimento, Mariana Machado Fidelis do Pedrosa, Fábio Oliveira Steffens, Maria Berenice R. Attili-Angelis, Derlene Najafzadeh, Mohammad Javad Queiroz-Telles, Flávio Souza, Emanuel Maltempi de Hoog, Sybren de |
| dc.subject.other.pt_BR.fl_str_mv |
Fonsecaea |
| topic |
Fonsecaea Genomics Chromoblastomycosis Fungi Genómica Cromoblastomicosis Hongos Genômica Cromoblastomicose Fungos |
| dc.subject.en.pt_BR.fl_str_mv |
Genomics Chromoblastomycosis Fungi |
| dc.subject.es.pt_BR.fl_str_mv |
Genómica Cromoblastomicosis Hongos |
| dc.subject.decs.pt_BR.fl_str_mv |
Genômica Cromoblastomicose Fungos |
| description |
Universidade Federal do Paraná. Departamento de Patologia Básica. Laboratório de Imunogenética e Histocompatibilidade. Curitiba, PR, Brasil / Universidade Federal do Paraná. Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil. |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2018-05-03T19:30:23Z |
| dc.date.available.fl_str_mv |
2018-05-03T19:30:23Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
VICENTE, Vânia A. et al. Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis. Frontiers in Microbiology, v. 8, n. 1924, p. 1-20, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26259 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2017.01924 |
| identifier_str_mv |
VICENTE, Vânia A. et al. Comparative genomics of Sibling Species of Fonsecaea associated with Human Chromoblastomycosis. Frontiers in Microbiology, v. 8, n. 1924, p. 1-20, 2017. 1664-302X 10.3389/fmicb.2017.01924 |
| url |
https://www.arca.fiocruz.br/handle/icict/26259 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/26259/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/26259/2/FaoroComparativ.pdf https://www.arca.fiocruz.br/bitstream/icict/26259/3/FaoroComparativ.pdf.txt |
| bitstream.checksum.fl_str_mv |
783568c2893d2e25a99990b126be1772 af51deed6d3e60618950577e576e6aad 06026655a31fdc682c97ec871b863324 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008860313550848 |