Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?

Detalhes bibliográficos
Autor(a) principal: Piergiorge, Rafael Mina
Data de Publicação: 2017
Outros Autores: Miranda, Antonio Basílio de, Guimarães, Ana Carolina, Catanho, Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1093/gbe/evx119
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24815
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.
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spelling Piergiorge, Rafael MinaMiranda, Antonio Basílio deGuimarães, Ana CarolinaCatanho, Marcos2018-02-15T12:03:39Z2018-02-15T12:03:39Z2017PIERGIORGE, Rafael Mirna; et al. Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?. Genome Biol. Evol., v. 9, n.6, p.1624–1636, July 2017.1759-6653https://www.arca.fiocruz.br/handle/icict/2481510.1093/gbe/evx119engOxford University PressHomo sapiensAtividade enzimáticaEvolução convergenteenzymatic activityconvergent evolutionH. sapiensFunctional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.Since enzymes catalyze almost all chemical reactions that occur in living organisms, it is crucial that genes encoding such activities are correctly identified and functionally characterized. Several studies suggest that the fraction of enzymatic activities in which multiple events of independent origin have taken place during evolution is substantial. However, this topic is still poorly explored, and a comprehensive investigation of the occurrence, distribution, and implications of these events has not been done so far. Fundamental questions, such as how analogous enzymes originate, why somany events of independent origin have apparently occurred during evolution, and what are the reasons for the coexistence in the same organism of distinct enzymatic forms catalyzing the same reaction, remain unanswered. Also, several isofunctional enzymes are still not recognized as nonhomologous, evenwith substantial evidence indicating different evolutionary histories. In this work, we begin to investigate the biological significance of the cooccurrence of nonhomologous isofunctional enzymes in human metabolism, characterizing functional analogous enzymes identified in metabolic pathways annotated in the human genome.Our hypothesis is that the coexistence of multiple enzymatic forms might not be interpreted as functional redundancy. Instead, these enzymatic forms may be implicated in distinct (and probably relevant) biological roles.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24815/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALantonio_miranda_etal_IOC.2017.pdfantonio_miranda_etal_IOC.2017.pdfapplication/pdf508879https://www.arca.fiocruz.br/bitstream/icict/24815/2/antonio_miranda_etal_IOC.2017.pdf0e1918804a34089e76b3cf23e1b65406MD52TEXTantonio_miranda_etal_IOC.2017.pdf.txtantonio_miranda_etal_IOC.2017.pdf.txtExtracted texttext/plain62566https://www.arca.fiocruz.br/bitstream/icict/24815/3/antonio_miranda_etal_IOC.2017.pdf.txtdfa3c3c16654d79343cc68433bfa03eaMD53icict/248152018-08-15 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dc.title.pt_BR.fl_str_mv Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
title Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
spellingShingle Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
Piergiorge, Rafael Mina
Homo sapiens
Atividade enzimática
Evolução convergente
enzymatic activity
convergent evolution
H. sapiens
title_short Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
title_full Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
title_fullStr Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
title_full_unstemmed Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
title_sort Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?
author Piergiorge, Rafael Mina
author_facet Piergiorge, Rafael Mina
Miranda, Antonio Basílio de
Guimarães, Ana Carolina
Catanho, Marcos
author_role author
author2 Miranda, Antonio Basílio de
Guimarães, Ana Carolina
Catanho, Marcos
author2_role author
author
author
dc.contributor.author.fl_str_mv Piergiorge, Rafael Mina
Miranda, Antonio Basílio de
Guimarães, Ana Carolina
Catanho, Marcos
dc.subject.other.pt_BR.fl_str_mv Homo sapiens
Atividade enzimática
Evolução convergente
topic Homo sapiens
Atividade enzimática
Evolução convergente
enzymatic activity
convergent evolution
H. sapiens
dc.subject.en.pt_BR.fl_str_mv enzymatic activity
convergent evolution
H. sapiens
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-15T12:03:39Z
dc.date.available.fl_str_mv 2018-02-15T12:03:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PIERGIORGE, Rafael Mirna; et al. Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?. Genome Biol. Evol., v. 9, n.6, p.1624–1636, July 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24815
dc.identifier.issn.pt_BR.fl_str_mv 1759-6653
dc.identifier.doi.none.fl_str_mv 10.1093/gbe/evx119
identifier_str_mv PIERGIORGE, Rafael Mirna; et al. Functional Analogy in HumanMetabolism: Enzymes with Different Biological Roles or Functional Redundancy?. Genome Biol. Evol., v. 9, n.6, p.1624–1636, July 2017.
1759-6653
10.1093/gbe/evx119
url https://www.arca.fiocruz.br/handle/icict/24815
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/24815/1/license.txt
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