A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35158 |
Resumo: | Johns Hopkins Hospital. Department of Pathology. Baltimore, MD USA. |
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Greer, Amy E.Ou, San-SanWilson, EthanPiwowar-Manning, EstelleForman, Michael S.McCauley, MarybethGamble, TheresaRuangyuttikarn, CholtichaHosseinipour, Mina C.Kumarasamy, NagalingeswaranNyirenda, MulindaGrinsztejn, BeatrizPilotto, Jose HenriqueKosashunhanan, NatthapolGonçalves de Melo, MarineideMakhema, JosephAkelo, VictorPanchia, RavindreBadal-Faesen, SharlaaChen, Ying Q.Cohen, Myron S.Eshleman, Susan H.Thio, Chloe L.Valsamakis, Alexandra2019-08-28T14:22:04Z2019-08-28T14:22:04Z2017GREER, Amy E. et al. A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multi-national clinical trial: HPTN 052. Journal of Acquired Immune Deficiency Syndromes, v. 76, n. 4, p. 1-16, Dec. 2017.https://www.arca.fiocruz.br/handle/icict/3515810.1097/QAI.0000000000001511engLippincott, Williams & Wilkinshttps://www.arca.fiocruz.br/handle/icict/25438HIVHIVHBVCD4 cell countChronic HBV infectionEndemic HBVPrevalence of HBV infectionHIV-HBV co-infectionA comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins Hospital. Department of Pathology. Baltimore, MD USA.Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA.Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA.Johns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA.Johns Hopkins Hospital. Department of Pathology. Baltimore, MD USA.FHI 360. Washington, DC, USA.FHI 360. Durham, NC, USA.Chiang Mai University. Research Institute for Health Sciences. Chaing Mai, Thailand.University of North Carolina. Chapel Hill, NC, USA / UNC Project-Malawi, Institute for Global Health and Infectious Diseases, Lilongwe, Malawi.YRGCARE Medical Centre, VHS. Chennai, India.College of Medicine-Johns Hopkins Project. Blantyre, Malawi.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand.Hospital Nossa Senhora da Conceição. Porto Alegre RS, Brasil.Botswana Harvard AIDS Institute. Gaborone, Botswana.Kenya Medical Research Institute. Kisumu, Kenya / Center for Disease Control. Kisumu, Kenya.University of the Witwatersrand. Perinatal HIV Research Unit. Johannesburg, South Africa / Soweto HPTN CRS. Soweto, South Africa.University of the Witwatersrand. Johannesburg, South Africa.Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA.University of North Carolina. Department of Medicine. Chapel Hill, NC, USAJohns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA.Johns Hopkins Hospital. School of Medicine. Department of Medicine. Baltimore, MD USA.Johns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA.Objective — Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(−)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). Method — HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(−) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisher’s exact, and median tests. Results — Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, “HBcAb”; 24.7% HBcAb and anti-HB surface antibody positive, “recovered”), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(−) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(−) [10.1% vs. 7.7%, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(−). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12% vs. 5.2%, P=0.037; AST ≤ Grade 2, 26% vs. 6.0%, P<0.001), CD4 trended lower, and HIV RNA was similar. Conclusions — HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/35158/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALva_Greer_E_etal_INI_2017.pdfva_Greer_E_etal_INI_2017.pdfapplication/pdf98197https://www.arca.fiocruz.br/bitstream/icict/35158/2/va_Greer_E_etal_INI_2017.pdfa0b85060001b17b51887ab80b69d0fdcMD52TEXTva_Greer_E_etal_INI_2017.pdf.txtva_Greer_E_etal_INI_2017.pdf.txtExtracted texttext/plain45907https://www.arca.fiocruz.br/bitstream/icict/35158/3/va_Greer_E_etal_INI_2017.pdf.txtf018393fe2f35f12d2d5422b1047242bMD53icict/351582019-08-29 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A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| title |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| spellingShingle |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 Greer, Amy E. HIV HIV HBV CD4 cell count Chronic HBV infection Endemic HBV Prevalence of HBV infection HIV-HBV co-infection |
| title_short |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| title_full |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| title_fullStr |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| title_full_unstemmed |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| title_sort |
A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 |
| author |
Greer, Amy E. |
| author_facet |
Greer, Amy E. Ou, San-San Wilson, Ethan Piwowar-Manning, Estelle Forman, Michael S. McCauley, Marybeth Gamble, Theresa Ruangyuttikarn, Cholticha Hosseinipour, Mina C. Kumarasamy, Nagalingeswaran Nyirenda, Mulinda Grinsztejn, Beatriz Pilotto, Jose Henrique Kosashunhanan, Natthapol Gonçalves de Melo, Marineide Makhema, Joseph Akelo, Victor Panchia, Ravindre Badal-Faesen, Sharlaa Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Thio, Chloe L. Valsamakis, Alexandra |
| author_role |
author |
| author2 |
Ou, San-San Wilson, Ethan Piwowar-Manning, Estelle Forman, Michael S. McCauley, Marybeth Gamble, Theresa Ruangyuttikarn, Cholticha Hosseinipour, Mina C. Kumarasamy, Nagalingeswaran Nyirenda, Mulinda Grinsztejn, Beatriz Pilotto, Jose Henrique Kosashunhanan, Natthapol Gonçalves de Melo, Marineide Makhema, Joseph Akelo, Victor Panchia, Ravindre Badal-Faesen, Sharlaa Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Thio, Chloe L. Valsamakis, Alexandra |
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author author author author author author author author author author author author author author author author author author author author author author author |
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Greer, Amy E. Ou, San-San Wilson, Ethan Piwowar-Manning, Estelle Forman, Michael S. McCauley, Marybeth Gamble, Theresa Ruangyuttikarn, Cholticha Hosseinipour, Mina C. Kumarasamy, Nagalingeswaran Nyirenda, Mulinda Grinsztejn, Beatriz Pilotto, Jose Henrique Kosashunhanan, Natthapol Gonçalves de Melo, Marineide Makhema, Joseph Akelo, Victor Panchia, Ravindre Badal-Faesen, Sharlaa Chen, Ying Q. Cohen, Myron S. Eshleman, Susan H. Thio, Chloe L. Valsamakis, Alexandra |
| dc.subject.other.pt_BR.fl_str_mv |
HIV |
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HIV HIV HBV CD4 cell count Chronic HBV infection Endemic HBV Prevalence of HBV infection HIV-HBV co-infection |
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HIV HBV CD4 cell count Chronic HBV infection Endemic HBV Prevalence of HBV infection HIV-HBV co-infection |
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Johns Hopkins Hospital. Department of Pathology. Baltimore, MD USA. |
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2017 |
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2017 |
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2019-08-28T14:22:04Z |
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2019-08-28T14:22:04Z |
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GREER, Amy E. et al. A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multi-national clinical trial: HPTN 052. Journal of Acquired Immune Deficiency Syndromes, v. 76, n. 4, p. 1-16, Dec. 2017. |
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https://www.arca.fiocruz.br/handle/icict/35158 10.1097/QAI.0000000000001511 |
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GREER, Amy E. et al. A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multi-national clinical trial: HPTN 052. Journal of Acquired Immune Deficiency Syndromes, v. 76, n. 4, p. 1-16, Dec. 2017. 10.1097/QAI.0000000000001511 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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