X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50850 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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Lima, Israel DinizRosa, Pablo Rodrigo daSilva Junior, Elias Barbosa daOliveira, Joyce Cristina Guimarães deFreitas, Elisangela Oliveira deNascimento, Danielle de OliveiraMorrot, AlexandreNimrichter, LeonardoPreviato, José OsvaldoPreviato, Lucia MendonçaLIma, Leonardo Freire deDecote‑Ricardo, DeboraLima, Celio Geraldo Freire de2022-01-23T13:29:28Z2022-01-23T13:29:28Z2021LIMA, Israel Diniz et al. X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection. Scientific Reports, v. 11, 18397, p. 1 - 11, 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/5085010.1038/s41598-021-97041-9engNatureCamundongosAlta suscetibilidadeInfecçãoCryptococcus gattiiCryptococcus gattiiInfectionX‑linked immunodeficient (XIDMiceHigh susceptibilityX‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil..Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of the disease, meningoencephalitis. The humoral response has already been described in limiting the progression of cryptococcosis where the B-1 cell seems to be responsible for producing natural IgM antibodies, crucial for combating fungal infections. The role of the B-1 cell in C. neoformans infection has been initially described, however the role of the humoral response of B-1 cells has not yet been evaluated during C. gattii infections. In the present study we tried to unravel this issue using XID mice, a murine model deficient in the Btk protein which compromises the development of B-1 lymphocytes. We use the XID mice compared to BALB/c mice that are sufficient for the B-1 population during C. gattii infection. Our model of chronic lung infection revealed that XID mice, unlike the sufficient group of B-1, had early mortality with significant weight loss, in addition to reduced levels of IgM and IgG specific to GXM isolated from the capsule of C. neoformans. In addition to this, we observed an increased fungal load in the blood and in the brain. We described an increase in the capsular size of C. gattii and the predominant presence of cytokines with a Th2 profile was also observed in these animals. Thus, the present study strongly points to a higher susceptibility of the XID mouse to C. gattii, which suggests that the presence of B-1 cells and anti-GXM antibodies is fundamental during the control of infection by C. gattii.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50850/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlexandreMorrot_IsraelLima_etal_IOC_2021.pdfAlexandreMorrot_IsraelLima_etal_IOC_2021.pdfapplication/pdf1416850https://www.arca.fiocruz.br/bitstream/icict/50850/2/AlexandreMorrot_IsraelLima_etal_IOC_2021.pdf83f52a7b4e8a9d137344682349bfc052MD52icict/508502022-01-23 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| dc.title.pt_BR.fl_str_mv |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| title |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| spellingShingle |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection Lima, Israel Diniz Camundongos Alta suscetibilidade Infecção Cryptococcus gattii Cryptococcus gattii Infection X‑linked immunodeficient (XID Mice High susceptibility |
| title_short |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| title_full |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| title_fullStr |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| title_full_unstemmed |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| title_sort |
X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection |
| author |
Lima, Israel Diniz |
| author_facet |
Lima, Israel Diniz Rosa, Pablo Rodrigo da Silva Junior, Elias Barbosa da Oliveira, Joyce Cristina Guimarães de Freitas, Elisangela Oliveira de Nascimento, Danielle de Oliveira Morrot, Alexandre Nimrichter, Leonardo Previato, José Osvaldo Previato, Lucia Mendonça LIma, Leonardo Freire de Decote‑Ricardo, Debora Lima, Celio Geraldo Freire de |
| author_role |
author |
| author2 |
Rosa, Pablo Rodrigo da Silva Junior, Elias Barbosa da Oliveira, Joyce Cristina Guimarães de Freitas, Elisangela Oliveira de Nascimento, Danielle de Oliveira Morrot, Alexandre Nimrichter, Leonardo Previato, José Osvaldo Previato, Lucia Mendonça LIma, Leonardo Freire de Decote‑Ricardo, Debora Lima, Celio Geraldo Freire de |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Israel Diniz Rosa, Pablo Rodrigo da Silva Junior, Elias Barbosa da Oliveira, Joyce Cristina Guimarães de Freitas, Elisangela Oliveira de Nascimento, Danielle de Oliveira Morrot, Alexandre Nimrichter, Leonardo Previato, José Osvaldo Previato, Lucia Mendonça LIma, Leonardo Freire de Decote‑Ricardo, Debora Lima, Celio Geraldo Freire de |
| dc.subject.other.pt_BR.fl_str_mv |
Camundongos Alta suscetibilidade Infecção Cryptococcus gattii |
| topic |
Camundongos Alta suscetibilidade Infecção Cryptococcus gattii Cryptococcus gattii Infection X‑linked immunodeficient (XID Mice High susceptibility |
| dc.subject.en.pt_BR.fl_str_mv |
Cryptococcus gattii Infection X‑linked immunodeficient (XID Mice High susceptibility |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2021 |
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2021 |
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2022-01-23T13:29:28Z |
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2022-01-23T13:29:28Z |
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info:eu-repo/semantics/article |
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LIMA, Israel Diniz et al. X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection. Scientific Reports, v. 11, 18397, p. 1 - 11, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50850 |
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2045-2322 |
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10.1038/s41598-021-97041-9 |
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LIMA, Israel Diniz et al. X‑linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection. Scientific Reports, v. 11, 18397, p. 1 - 11, 2021. 2045-2322 10.1038/s41598-021-97041-9 |
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