Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12706 |
Resumo: | Universidade Federal de Minas Gerais Programa de Pós-graduação em Genética. Belo Horizonte, MG, Brasil/Myleus Biotechnology Research Team. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil |
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Palhares, Rafael MeloDrummond, Marcela GonçalvesBrasil, Bruno dos Santos Alves FigueiredoCosenza, Gustavo PereiraBrandão, Maria das Graças LinsOliveira, Guilherme Correa de2016-02-05T11:26:30Z2016-02-05T11:26:30Z2015PALHARES, Rafael Melo et al. Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality. PLoS One, vol. 10, n. 5, p.e0127866, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1270610.1371/journal.pone.0127866engPublic Library of ScienceMedicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Qualityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais Programa de Pós-graduação em Genética. Belo Horizonte, MG, Brasil/Myleus Biotechnology Research Team. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, BrasilMyleus Biotechnology Research Team. Belo Horizonte, MG, BrasilEmpresa Brasileira de Agropecuaria. Agroenergia, Brasilia, DF BrasilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Laboratório de Farmacognosia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Laboratório de Farmacognosia. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais CEPLAMT. Belo Horizonte, MG, Brasil. Museu de História Natural e Jardim Botânico/Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, BrasilMedicinal plants are used throughout the world, and the regulations defining their proper use, such as identification of the correct species and verification of the presence, purity and concentration of the required chemical compounds, are widely recognized. Herbal medicines are made from vegetal drugs, the processed products of medicinal species. These processed materials present a number of challenges in terms of botanical identification, and according to the World Health Organization (WHO), the use of incorrect species is a threat to consumer safety. The samples used in this study consisted of the dried leaves, flowers and roots of 257 samples from 8 distinct species approved by the WHO for the production of medicinal herbs and sold in Brazilian markets. Identification of the samples in this study using DNA barcoding (matK, rbcL and ITS2 regions) revealed that the level of substitutions may be as high as 71%. Using qualitative and quantitative chemical analyses, this study identified situations in which the correct species was being sold, but the chemical compounds were not present. Even more troubling, some samples identified as substitutions using DNA barcoding contained the chemical compounds from the correct species at the minimum required concentration. This last situation may lead to the use of unknown species or species whose safety for human consumption remains unknown. This study concludes that DNA barcoding should be used in a complementary manner for species identification with chemical analyses to detect and quantify the required chemical compounds, thus improving the quality of this class of medicinesmedicinal herbs/consumer safetyvegetal drugsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12706/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMedicinal Plants Recommended by the World.pdfMedicinal Plants Recommended by the World.pdfapplication/pdf789722https://www.arca.fiocruz.br/bitstream/icict/12706/2/Medicinal%20Plants%20Recommended%20by%20the%20World.pdf54fabedaaf9f5272018e35ae643b852eMD52TEXTMedicinal Plants Recommended by the World.pdf.txtMedicinal Plants Recommended by the World.pdf.txtExtracted 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Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| title |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| spellingShingle |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality Palhares, Rafael Melo medicinal herbs/consumer safety vegetal drugs |
| title_short |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| title_full |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| title_fullStr |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| title_full_unstemmed |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| title_sort |
Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality |
| author |
Palhares, Rafael Melo |
| author_facet |
Palhares, Rafael Melo Drummond, Marcela Gonçalves Brasil, Bruno dos Santos Alves Figueiredo Cosenza, Gustavo Pereira Brandão, Maria das Graças Lins Oliveira, Guilherme Correa de |
| author_role |
author |
| author2 |
Drummond, Marcela Gonçalves Brasil, Bruno dos Santos Alves Figueiredo Cosenza, Gustavo Pereira Brandão, Maria das Graças Lins Oliveira, Guilherme Correa de |
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author author author author author |
| dc.contributor.author.fl_str_mv |
Palhares, Rafael Melo Drummond, Marcela Gonçalves Brasil, Bruno dos Santos Alves Figueiredo Cosenza, Gustavo Pereira Brandão, Maria das Graças Lins Oliveira, Guilherme Correa de |
| dc.subject.en.pt_BR.fl_str_mv |
medicinal herbs/consumer safety vegetal drugs |
| topic |
medicinal herbs/consumer safety vegetal drugs |
| description |
Universidade Federal de Minas Gerais Programa de Pós-graduação em Genética. Belo Horizonte, MG, Brasil/Myleus Biotechnology Research Team. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil |
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2015 |
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2015 |
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2016-02-05T11:26:30Z |
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PALHARES, Rafael Melo et al. Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality. PLoS One, vol. 10, n. 5, p.e0127866, 2015. |
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10.1371/journal.pone.0127866 |
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PALHARES, Rafael Melo et al. Medicinal Plants Recommended by the World Health Organization: DNA Barcode Identification Associated with Chemical Analyses Guarantees Their Quality. PLoS One, vol. 10, n. 5, p.e0127866, 2015. 1932-6203 10.1371/journal.pone.0127866 |
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