Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis

Detalhes bibliográficos
Autor(a) principal: Alves, Felipe de Andrade Vieira
Data de Publicação: 2022
Outros Autores: Oliveira, Lucca de Lima S., Salomão, Natáia Gedeão, Provance Jr., David William, Oliveira, Carlos Alberto Basilio de, Oliveira, Rodrigo Basílio de, Moragas, Leandro Junqueira, Carvalho, Jorge José de, Borges, Ronaldo Mohana, Rabello, Kíssila, Paes, Marciano Viana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51567
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
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spelling Alves, Felipe de Andrade VieiraOliveira, Lucca de Lima S.Salomão, Natáia GedeãoProvance Jr., David WilliamOliveira, Carlos Alberto Basilio deOliveira, Rodrigo Basílio deMoragas, Leandro JunqueiraCarvalho, Jorge José deBorges, Ronaldo MohanaRabello, KíssilaPaes, Marciano Viana2022-03-05T17:59:50Z2022-03-05T17:59:50Z2022ALVES, Felipe de Andrade Vieira et al. Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis. Plos One, v. 17, n. 1, e0262785, p. 1 - 16, Jan. 2022.1932-6203https://www.arca.fiocruz.br/handle/icict/5156710.1371/journal.pone.0262785engPublic Library of ScienceCitocinasMediadores inflamatóriosMarcadoresDanos intersticiaisPâncreasFebre da DenguePancreatite agudaCytokinesInflammatory mediatorsMarkersInterstitial damagePancreasDengue feveracute pancreatitisCytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Dengue viral (DENV) infections can lead to acute pancreatitis and associated tissue damage. This study examined the pancreas from two fatal cases of DENV for histopathological changes as well as for the detection of cytokines, and other inflammatory mediators. Tissue sections were prepared for examination by ultrastructural and histopathological techniques. Sections from the pancreas of non-infected individuals were prepared in parallel as a control. The presence of viral replication in macrophages was detected by co-staining for the proteins NS3 and CD68 by immunofluorescence. Immunohistochemistry was used to detect cells that expressed cytokines and inflammatory mediators to characterize the inflammatory response. Edema, acinar necrosis and fibrosis areas associated with a mononuclear infiltrate were found in infected tissues. The major site of virus replication appeared to be macrophages based on their exclusive presentation of the viral protein NS3. Pancreatic tissues from the infected individuals also displayed increased levels of high mobility group box-1, caspase-3, gelatinase B and tumor necrosis factor alpha compared to controls. The presence of virus replicating macrophages in the pancreas was associated with multiple changes in tissue structure that included elevated levels of cytokines and inflammatory markers that may differentiate acute pancreatitis due to DENV infections from other causes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51567/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFeliepAlves_MarcianoPaes_etal_IOC_2022.pdfFeliepAlves_MarcianoPaes_etal_IOC_2022.pdfapplication/pdf3429337https://www.arca.fiocruz.br/bitstream/icict/51567/2/FeliepAlves_MarcianoPaes_etal_IOC_2022.pdf6ab8a2ebf40e031900442eb73c1ef603MD52icict/515672023-09-05 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dc.title.pt_BR.fl_str_mv Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
title Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
spellingShingle Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
Alves, Felipe de Andrade Vieira
Citocinas
Mediadores inflamatórios
Marcadores
Danos intersticiais
Pâncreas
Febre da Dengue
Pancreatite aguda
Cytokines
Inflammatory mediators
Markers
Interstitial damage
Pancreas
Dengue fever
acute pancreatitis
title_short Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
title_full Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
title_fullStr Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
title_full_unstemmed Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
title_sort Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis
author Alves, Felipe de Andrade Vieira
author_facet Alves, Felipe de Andrade Vieira
Oliveira, Lucca de Lima S.
Salomão, Natáia Gedeão
Provance Jr., David William
Oliveira, Carlos Alberto Basilio de
Oliveira, Rodrigo Basílio de
Moragas, Leandro Junqueira
Carvalho, Jorge José de
Borges, Ronaldo Mohana
Rabello, Kíssila
Paes, Marciano Viana
author_role author
author2 Oliveira, Lucca de Lima S.
Salomão, Natáia Gedeão
Provance Jr., David William
Oliveira, Carlos Alberto Basilio de
Oliveira, Rodrigo Basílio de
Moragas, Leandro Junqueira
Carvalho, Jorge José de
Borges, Ronaldo Mohana
Rabello, Kíssila
Paes, Marciano Viana
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Felipe de Andrade Vieira
Oliveira, Lucca de Lima S.
Salomão, Natáia Gedeão
Provance Jr., David William
Oliveira, Carlos Alberto Basilio de
Oliveira, Rodrigo Basílio de
Moragas, Leandro Junqueira
Carvalho, Jorge José de
Borges, Ronaldo Mohana
Rabello, Kíssila
Paes, Marciano Viana
dc.subject.other.pt_BR.fl_str_mv Citocinas
Mediadores inflamatórios
Marcadores
Danos intersticiais
Pâncreas
Febre da Dengue
Pancreatite aguda
topic Citocinas
Mediadores inflamatórios
Marcadores
Danos intersticiais
Pâncreas
Febre da Dengue
Pancreatite aguda
Cytokines
Inflammatory mediators
Markers
Interstitial damage
Pancreas
Dengue fever
acute pancreatitis
dc.subject.en.pt_BR.fl_str_mv Cytokines
Inflammatory mediators
Markers
Interstitial damage
Pancreas
Dengue fever
acute pancreatitis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-05T17:59:50Z
dc.date.available.fl_str_mv 2022-03-05T17:59:50Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, Felipe de Andrade Vieira et al. Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis. Plos One, v. 17, n. 1, e0262785, p. 1 - 16, Jan. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51567
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0262785
identifier_str_mv ALVES, Felipe de Andrade Vieira et al. Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis. Plos One, v. 17, n. 1, e0262785, p. 1 - 16, Jan. 2022.
1932-6203
10.1371/journal.pone.0262785
url https://www.arca.fiocruz.br/handle/icict/51567
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51567/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51567/2/FeliepAlves_MarcianoPaes_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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