A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20525 |
Resumo: | Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Santos, Hadassa CamposHorimoto, Andréa Roseli Vancan RussoSantos, Eduardo Martín TarazonaSoares, Fernanda RodriguesBarreto, Maurício LimaHorta, Bernardo LessaCosta, Maria Fernanda Furtado de LimaGouveia, Mateus HenriqueMachado, MoaraSilva, Thiago Magalhães daSanches, José MaurícioEsteban, NubiaMagalhães, Wagner Carlos SantosRodrigues, Maíra RibeiroKehdy, Fernanda de Souza GomesPereira, Alexandre da CostaThe Brazilian EPIGEN Project Consortium2017-08-07T13:32:45Z2017-08-07T13:32:45Z2016SANTOS, H. C. et al. A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set. European Journal of Human Genetics, v. 24, p. 725–731, 2016.1018-4813https://www.arca.fiocruz.br/handle/icict/2052510.1038/ejhg.2015.187Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Department of Science and Technology (DECIT/ SCTIE) and National Fund for Scientific and Technological Development (FNDCT), Ministry of Health, Brazil; Funding of Studies and Projects (FINEP), Ministry of Science and Technology, Brazil; Coordination of Improvement of Higher Education Personnel (CAPES), Ministry of Education, Brazil. HCS is supported by a grant from the São Paulo Research Foundation (FAPESP).Medical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, BrazilMedical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Bahia. Institute of Public Health. Salvador, BA, BrazilFederal University of Pelotas. Porto Alegre, RGS, BrazilOswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Bahia. Institute of Public Health. Salvador, BA, BrazilMedical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, BrazilMedical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilFederal University of Minas Gerais. General Biology Department. Belo Horizonte, MG, BrazilMedical School of University of São Paulo. Heart Institute. Laboratory of Genetics and Molecular Cardiology. São Paulo, SP, BrazilThe Brazilian EPIGEN Project ConsortiumThe Brazilian population is considered to be highly admixed. The main contributing ancestral populations were European and African, with Amerindians contributing to a lesser extent. The aims of this study were to provide a resource for determining and quantifying individual continental ancestry using the smallest number of SNPs possible, thus allowing for a cost- and time-efficient strategy for genomic ancestry determination. We identified and validated a minimum set of 192 ancestry informative markers (AIMs) for the genetic ancestry determination of Brazilian populations. These markers were selected on the basis of their distribution throughout the human genome, and their capacity of being genotyped on widely available commercial platforms. We analyzed genotyping data from 6487 individuals belonging to three Brazilian cohorts. Estimates of individual admixture using this 192 AIM panels were highly correlated with estimates using ~370 000 genome-wide SNPs: 91%, 92%, and 74% of, respectively, African, European, and Native American ancestry components. Besides that, 192 AIMs are well distributed among populations from these ancestral continents, allowing greater freedom in future studies with this panel regarding the choice of reference populations. We also observed that genetic ancestry inferred by AIMs provides similar association results to the one obtained using ancestry inferred by genomic data (370 K SNPs) in a simple regression model with rs1426654, related to skin pigmentation, genotypes as dependent variable. In conclusion, these markers can be used to identify and accurately quantify ancestry of Latin Americans or US Hispanics/Latino individuals, in particular in the context of fine-mapping strategies that require the quantification of continental ancestry in thousands of individuals.engNature Publishing GroupPopulaçãoGrupo de ascendência africana continentalGrupo de Ancestralidade no Continente EuropeuMarcadores genéticosGenoma humanoHumanosBrasilPopulationGroup of African Continental AncestryEuropean Continental Ancestry GroupGenetic MarkersGenome HumanHumansBrazilA minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian setinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20525/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos HC A minimum set....pdfSantos HC A minimum set....pdfapplication/pdf1062773https://www.arca.fiocruz.br/bitstream/icict/20525/2/Santos%20HC%20A%20minimum%20set....pdf9434fea963814081a138b951934c70aaMD52TEXTSantos HC A minimum set....pdf.txtSantos HC A minimum set....pdf.txtExtracted texttext/plain41386https://www.arca.fiocruz.br/bitstream/icict/20525/3/Santos%20HC%20A%20minimum%20set....pdf.txt0f1598de6b460de0079eadd49ac38044MD53icict/205252023-03-15 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| dc.title.pt_BR.fl_str_mv |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| title |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| spellingShingle |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set Santos, Hadassa Campos População Grupo de ascendência africana continental Grupo de Ancestralidade no Continente Europeu Marcadores genéticos Genoma humano Humanos Brasil Population Group of African Continental Ancestry European Continental Ancestry Group Genetic Markers Genome Human Humans Brazil |
| title_short |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| title_full |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| title_fullStr |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| title_full_unstemmed |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| title_sort |
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set |
| author |
Santos, Hadassa Campos |
| author_facet |
Santos, Hadassa Campos Horimoto, Andréa Roseli Vancan Russo Santos, Eduardo Martín Tarazona Soares, Fernanda Rodrigues Barreto, Maurício Lima Horta, Bernardo Lessa Costa, Maria Fernanda Furtado de Lima Gouveia, Mateus Henrique Machado, Moara Silva, Thiago Magalhães da Sanches, José Maurício Esteban, Nubia Magalhães, Wagner Carlos Santos Rodrigues, Maíra Ribeiro Kehdy, Fernanda de Souza Gomes Pereira, Alexandre da Costa The Brazilian EPIGEN Project Consortium |
| author_role |
author |
| author2 |
Horimoto, Andréa Roseli Vancan Russo Santos, Eduardo Martín Tarazona Soares, Fernanda Rodrigues Barreto, Maurício Lima Horta, Bernardo Lessa Costa, Maria Fernanda Furtado de Lima Gouveia, Mateus Henrique Machado, Moara Silva, Thiago Magalhães da Sanches, José Maurício Esteban, Nubia Magalhães, Wagner Carlos Santos Rodrigues, Maíra Ribeiro Kehdy, Fernanda de Souza Gomes Pereira, Alexandre da Costa The Brazilian EPIGEN Project Consortium |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Hadassa Campos Horimoto, Andréa Roseli Vancan Russo Santos, Eduardo Martín Tarazona Soares, Fernanda Rodrigues Barreto, Maurício Lima Horta, Bernardo Lessa Costa, Maria Fernanda Furtado de Lima Gouveia, Mateus Henrique Machado, Moara Silva, Thiago Magalhães da Sanches, José Maurício Esteban, Nubia Magalhães, Wagner Carlos Santos Rodrigues, Maíra Ribeiro Kehdy, Fernanda de Souza Gomes Pereira, Alexandre da Costa The Brazilian EPIGEN Project Consortium |
| dc.subject.other.pt_BR.fl_str_mv |
População Grupo de ascendência africana continental Grupo de Ancestralidade no Continente Europeu Marcadores genéticos Genoma humano Humanos Brasil |
| topic |
População Grupo de ascendência africana continental Grupo de Ancestralidade no Continente Europeu Marcadores genéticos Genoma humano Humanos Brasil Population Group of African Continental Ancestry European Continental Ancestry Group Genetic Markers Genome Human Humans Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Population Group of African Continental Ancestry European Continental Ancestry Group Genetic Markers Genome Human Humans Brazil |
| description |
Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2016 |
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2016 |
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2017-08-07T13:32:45Z |
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2017-08-07T13:32:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SANTOS, H. C. et al. A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set. European Journal of Human Genetics, v. 24, p. 725–731, 2016. |
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https://www.arca.fiocruz.br/handle/icict/20525 |
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1018-4813 |
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10.1038/ejhg.2015.187 |
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SANTOS, H. C. et al. A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set. European Journal of Human Genetics, v. 24, p. 725–731, 2016. 1018-4813 10.1038/ejhg.2015.187 |
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Nature Publishing Group |
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Nature Publishing Group |
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