Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Bastos, Claudilson José de Carvalho
Data de Publicação: 2010
Outros Autores: Aras Junior, Roque, Mota, Gildo de Oliveira, Reis, Francisco, Dias, Juarez Pereira, Jesus, Robson Silva de, Freire, Miralba Silva, Araújo, Eline Gomes de, Prazeres, Juliana Moura Bastos, Grassi, Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8517
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
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spelling Bastos, Claudilson José de CarvalhoAras Junior, RoqueMota, Gildo de OliveiraReis, FranciscoDias, Juarez PereiraJesus, Robson Silva deFreire, Miralba SilvaAraújo, Eline Gomes dePrazeres, Juliana Moura BastosGrassi, Maria Fernanda Rios2014-10-06T19:02:57Z2014-10-06T19:02:57Z2010BASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.1935-2735https://www.arca.fiocruz.br/handle/icict/851710.1371/journal.pntd.0000711engPublic Library of ScienceDoença de ChagasSurtos de DoençasDoença AgudaAdolescenteAdultoEpidemiologiaDiagnósticoCriançaDoença de Chagas/quimioterapiaSurtos de DoençasDoença AgudaAdolescenteAdultoBrasil/epidemiologiaDoença de Chagas /diagnósticoDoença de Chagas /epidemiologiaCriançaEcocardiografia DopplerEletrocardiografiaFemininoHumanosMasculinoNitroimidazóis /uso terapêuticoRadiografia TorácicaResultado do TratamentoTripanossomicidas /uso terapêuticoTrypanosoma cruzi /isolamento & purificaçãoClinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.Couto Maia Hospital. Salvador, BA, Brasil.Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.BACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8517/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALBastos C J C Clinical outocomes....pdfBastos C J C Clinical outocomes....pdfapplication/pdf871705https://www.arca.fiocruz.br/bitstream/icict/8517/2/Bastos%20C%20J%20C%20Clinical%20outocomes....pdf1cbb85d22a1b922097ab31ddf49fc584MD52TEXTBastos C J C Clinical outocomes....pdf.txtBastos C J C Clinical outocomes....pdf.txtExtracted texttext/plain33079https://www.arca.fiocruz.br/bitstream/icict/8517/3/Bastos%20C%20J%20C%20Clinical%20outocomes....pdf.txt0634cb05bf707ae838a9c965d08fbc01MD53icict/85172023-03-15 14:33:06.154oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
title Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
spellingShingle Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
Bastos, Claudilson José de Carvalho
Doença de Chagas
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Epidemiologia
Diagnóstico
Criança
Doença de Chagas/quimioterapia
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Brasil/epidemiologia
Doença de Chagas /diagnóstico
Doença de Chagas /epidemiologia
Criança
Ecocardiografia Doppler
Eletrocardiografia
Feminino
Humanos
Masculino
Nitroimidazóis /uso terapêutico
Radiografia Torácica
Resultado do Tratamento
Tripanossomicidas /uso terapêutico
Trypanosoma cruzi /isolamento & purificação
title_short Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
title_full Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
title_fullStr Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
title_full_unstemmed Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
title_sort Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
author Bastos, Claudilson José de Carvalho
author_facet Bastos, Claudilson José de Carvalho
Aras Junior, Roque
Mota, Gildo de Oliveira
Reis, Francisco
Dias, Juarez Pereira
Jesus, Robson Silva de
Freire, Miralba Silva
Araújo, Eline Gomes de
Prazeres, Juliana Moura Bastos
Grassi, Maria Fernanda Rios
author_role author
author2 Aras Junior, Roque
Mota, Gildo de Oliveira
Reis, Francisco
Dias, Juarez Pereira
Jesus, Robson Silva de
Freire, Miralba Silva
Araújo, Eline Gomes de
Prazeres, Juliana Moura Bastos
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bastos, Claudilson José de Carvalho
Aras Junior, Roque
Mota, Gildo de Oliveira
Reis, Francisco
Dias, Juarez Pereira
Jesus, Robson Silva de
Freire, Miralba Silva
Araújo, Eline Gomes de
Prazeres, Juliana Moura Bastos
Grassi, Maria Fernanda Rios
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Epidemiologia
Diagnóstico
Criança
topic Doença de Chagas
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Epidemiologia
Diagnóstico
Criança
Doença de Chagas/quimioterapia
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Brasil/epidemiologia
Doença de Chagas /diagnóstico
Doença de Chagas /epidemiologia
Criança
Ecocardiografia Doppler
Eletrocardiografia
Feminino
Humanos
Masculino
Nitroimidazóis /uso terapêutico
Radiografia Torácica
Resultado do Tratamento
Tripanossomicidas /uso terapêutico
Trypanosoma cruzi /isolamento & purificação
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas/quimioterapia
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Brasil/epidemiologia
Doença de Chagas /diagnóstico
Doença de Chagas /epidemiologia
Criança
Ecocardiografia Doppler
Eletrocardiografia
Feminino
Humanos
Masculino
Nitroimidazóis /uso terapêutico
Radiografia Torácica
Resultado do Tratamento
Tripanossomicidas /uso terapêutico
Trypanosoma cruzi /isolamento & purificação
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-10-06T19:02:57Z
dc.date.available.fl_str_mv 2014-10-06T19:02:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8517
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0000711
identifier_str_mv BASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.
1935-2735
10.1371/journal.pntd.0000711
url https://www.arca.fiocruz.br/handle/icict/8517
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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