Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity

Detalhes bibliográficos
Autor(a) principal: Martins, Yuri Chaves
Data de Publicação: 2023
Outros Autores: Jurberg, Arnon Dias, Ribeiro, Cláudio Tadeu Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58937
Resumo: Saint Louis University School of Medicine. Department of Anesthesiology. St. Louis, MO, USA.
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spelling Martins, Yuri ChavesJurberg, Arnon DiasRibeiro, Cláudio Tadeu Daniel2023-06-06T10:52:49Z2023-06-06T10:52:49Z2023MARTINS, Yuri Chaves; JURBERG, Arnon Dias; RIBEIRO, Cláudio Tadeu Daniel. Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity. Microorganisms v. 11, 1472, p. 1-13, June 2023.2076-2607https://www.arca.fiocruz.br/handle/icict/5893710.3390/microorganisms11061472engMDPICompartilhamento de antígenoAutoimunidadeBioinformáticaRelação hospedeiro/parasitaTolerância imunológicaParasitaAntigen sharingAutoimmunityBioinformaticsHost/parasite relationshipImmune toleranceParasiteVisiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSaint Louis University School of Medicine. Department of Anesthesiology. St. Louis, MO, USA.Universidade Estácio de Sá, Instituto de Educação Médica, Campus Vista Carioca. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Laboratório de Animais Transgênicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária e Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil.The concept of molecular mimicry describes situations in which antigen sharing between parasites and hosts could benefit pathogen evasion from host immune responses. However, antigen sharing can generate host responses to parasite-derived self-like peptides, triggering autoimmunity. Since its conception, molecular mimicry and the consequent potential cross-reactivity following infections have been repeatedly described in humans, raising increasing interest among immunologists. Here, we reviewed this concept focusing on the challenge of maintaining host immune tolerance to self-components in parasitic diseases. We focused on the studies that used genomics and bioinformatics to estimate the extent of antigen sharing between proteomes of different organisms. In addition, we comparatively analyzed human and murine proteomes for peptide sharing with proteomes of pathogenic and non-pathogenic organisms. We conclude that, although the amount of antigenic sharing between hosts and both pathogenic and non-pathogenic parasites and bacteria is massive, the degree of this antigen sharing is not related to pathogenicity or virulence. In addition, because the development of autoimmunity in response to infections by microorganisms endowed with cross-reacting antigens is rare, we conclude that molecular mimicry by itself is not a sufficient factor to disrupt intact self-tolerance mechanisms.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58937/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudioTRibeiro_YuriMartins_etal_IOC_2023.pdfClaudioTRibeiro_YuriMartins_etal_IOC_2023.pdfapplication/pdf1803091https://www.arca.fiocruz.br/bitstream/icict/58937/2/ClaudioTRibeiro_YuriMartins_etal_IOC_2023.pdfa336cd0e0c79d4df884d56f7ec21dd22MD52icict/589372023-09-04 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dc.title.en_US.fl_str_mv Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
title Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
spellingShingle Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
Martins, Yuri Chaves
Compartilhamento de antígeno
Autoimunidade
Bioinformática
Relação hospedeiro/parasita
Tolerância imunológica
Parasita
Antigen sharing
Autoimmunity
Bioinformatics
Host/parasite relationship
Immune tolerance
Parasite
title_short Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
title_full Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
title_fullStr Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
title_full_unstemmed Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
title_sort Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity
author Martins, Yuri Chaves
author_facet Martins, Yuri Chaves
Jurberg, Arnon Dias
Ribeiro, Cláudio Tadeu Daniel
author_role author
author2 Jurberg, Arnon Dias
Ribeiro, Cláudio Tadeu Daniel
author2_role author
author
dc.contributor.author.fl_str_mv Martins, Yuri Chaves
Jurberg, Arnon Dias
Ribeiro, Cláudio Tadeu Daniel
dc.subject.other.en_US.fl_str_mv Compartilhamento de antígeno
Autoimunidade
Bioinformática
Relação hospedeiro/parasita
Tolerância imunológica
Parasita
topic Compartilhamento de antígeno
Autoimunidade
Bioinformática
Relação hospedeiro/parasita
Tolerância imunológica
Parasita
Antigen sharing
Autoimmunity
Bioinformatics
Host/parasite relationship
Immune tolerance
Parasite
dc.subject.en.en_US.fl_str_mv Antigen sharing
Autoimmunity
Bioinformatics
Host/parasite relationship
Immune tolerance
Parasite
description Saint Louis University School of Medicine. Department of Anesthesiology. St. Louis, MO, USA.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-06T10:52:49Z
dc.date.available.fl_str_mv 2023-06-06T10:52:49Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Yuri Chaves; JURBERG, Arnon Dias; RIBEIRO, Cláudio Tadeu Daniel. Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity. Microorganisms v. 11, 1472, p. 1-13, June 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58937
dc.identifier.issn.en_US.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/microorganisms11061472
identifier_str_mv MARTINS, Yuri Chaves; JURBERG, Arnon Dias; RIBEIRO, Cláudio Tadeu Daniel. Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity. Microorganisms v. 11, 1472, p. 1-13, June 2023.
2076-2607
10.3390/microorganisms11061472
url https://www.arca.fiocruz.br/handle/icict/58937
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58937/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58937/2/ClaudioTRibeiro_YuriMartins_etal_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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