First report on ototoxicity of meglumine antitoniate
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10999 |
Resumo: | FAPERJ, CNPq |
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Rosalino, Cláudia Maria ValeteMelo, Maria Helena AraujoBezerra, Débora Cristina de OliveiraBarcelos, Renata Oliveira deFerreira, Vanessa de MeloTorraca, Tânia Salgado de SousaMartins, Ana Cristina da CostaMoreira, João SoaresVargas, Mirian Catherine MelgaresBraga, Frederico Pereira BomSalgueiro, Mariza de MatosSaheki, Maurício NaotoSchubach, Armando Oliveira2015-06-29T15:29:12Z2015-06-29T15:29:12Z2014ROSALINO, Cláudia Maria Valete et al. First report on ototoxicity of meglumine antitoniate. Rev. Inst. Med. trop. S. Paulo, v.56, n.5, p.439-442, 2014.0036-4665https://www.arca.fiocruz.br/handle/icict/1099910.1590/S0036-466520140005000121678-9946FAPERJ, CNPqFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Otorrino e Oftalmologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilPentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.porInstituto de Medicina TropicalAntimoniato de MegluminaLeishmaniasis, MucocutaneousDrug-Related Side Effects and Adverse ReactionsHearing LossTinnitusDizzinessMeglumine AntimoniateLeishmaniose MucocutâneaEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosPerda AuditivaZumbidoTonturaFirst report on ototoxicity of meglumine antitoniateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/10999/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALFirst report on ototoxicity of meglumine antimoniate.pdfFirst report on ototoxicity of meglumine antimoniate.pdfapplication/pdf213538https://www.arca.fiocruz.br/bitstream/icict/10999/2/First%20report%20on%20ototoxicity%20of%20meglumine%20antimoniate.pdf184df8c110fae2c8f71c695a84988b1bMD52TEXTFirst report on ototoxicity of meglumine antimoniate.pdf.txtFirst report on ototoxicity of meglumine antimoniate.pdf.txtExtracted texttext/plain23361https://www.arca.fiocruz.br/bitstream/icict/10999/3/First%20report%20on%20ototoxicity%20of%20meglumine%20antimoniate.pdf.txt84fbcef94a54697a534248ffd357a26aMD53icict/109992018-04-04 07:58:12.971oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-04T10:58:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
First report on ototoxicity of meglumine antitoniate |
| title |
First report on ototoxicity of meglumine antitoniate |
| spellingShingle |
First report on ototoxicity of meglumine antitoniate Rosalino, Cláudia Maria Valete Antimoniato de Meglumina Leishmaniasis, Mucocutaneous Drug-Related Side Effects and Adverse Reactions Hearing Loss Tinnitus Dizziness Meglumine Antimoniate Leishmaniose Mucocutânea Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Perda Auditiva Zumbido Tontura |
| title_short |
First report on ototoxicity of meglumine antitoniate |
| title_full |
First report on ototoxicity of meglumine antitoniate |
| title_fullStr |
First report on ototoxicity of meglumine antitoniate |
| title_full_unstemmed |
First report on ototoxicity of meglumine antitoniate |
| title_sort |
First report on ototoxicity of meglumine antitoniate |
| author |
Rosalino, Cláudia Maria Valete |
| author_facet |
Rosalino, Cláudia Maria Valete Melo, Maria Helena Araujo Bezerra, Débora Cristina de Oliveira Barcelos, Renata Oliveira de Ferreira, Vanessa de Melo Torraca, Tânia Salgado de Sousa Martins, Ana Cristina da Costa Moreira, João Soares Vargas, Mirian Catherine Melgares Braga, Frederico Pereira Bom Salgueiro, Mariza de Matos Saheki, Maurício Naoto Schubach, Armando Oliveira |
| author_role |
author |
| author2 |
Melo, Maria Helena Araujo Bezerra, Débora Cristina de Oliveira Barcelos, Renata Oliveira de Ferreira, Vanessa de Melo Torraca, Tânia Salgado de Sousa Martins, Ana Cristina da Costa Moreira, João Soares Vargas, Mirian Catherine Melgares Braga, Frederico Pereira Bom Salgueiro, Mariza de Matos Saheki, Maurício Naoto Schubach, Armando Oliveira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rosalino, Cláudia Maria Valete Melo, Maria Helena Araujo Bezerra, Débora Cristina de Oliveira Barcelos, Renata Oliveira de Ferreira, Vanessa de Melo Torraca, Tânia Salgado de Sousa Martins, Ana Cristina da Costa Moreira, João Soares Vargas, Mirian Catherine Melgares Braga, Frederico Pereira Bom Salgueiro, Mariza de Matos Saheki, Maurício Naoto Schubach, Armando Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Antimoniato de Meglumina |
| topic |
Antimoniato de Meglumina Leishmaniasis, Mucocutaneous Drug-Related Side Effects and Adverse Reactions Hearing Loss Tinnitus Dizziness Meglumine Antimoniate Leishmaniose Mucocutânea Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Perda Auditiva Zumbido Tontura |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis, Mucocutaneous Drug-Related Side Effects and Adverse Reactions Hearing Loss Tinnitus Dizziness Meglumine Antimoniate |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Mucocutânea Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Perda Auditiva Zumbido Tontura |
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FAPERJ, CNPq |
| publishDate |
2014 |
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2014 |
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2015-06-29T15:29:12Z |
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2015-06-29T15:29:12Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
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ROSALINO, Cláudia Maria Valete et al. First report on ototoxicity of meglumine antitoniate. Rev. Inst. Med. trop. S. Paulo, v.56, n.5, p.439-442, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10999 |
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0036-4665 |
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10.1590/S0036-46652014000500012 |
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1678-9946 |
| identifier_str_mv |
ROSALINO, Cláudia Maria Valete et al. First report on ototoxicity of meglumine antitoniate. Rev. Inst. Med. trop. S. Paulo, v.56, n.5, p.439-442, 2014. 0036-4665 10.1590/S0036-46652014000500012 1678-9946 |
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Instituto de Medicina Tropical |
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Instituto de Medicina Tropical |
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