Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16536 |
Resumo: | Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, Argentina |
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Gimenez, G.Belaunzarán, M. L.Magalhães, K .G.Poncini, C. V.Lammel, E. M.González Cappa, S. M.Bozza, P. T.Isola, E. L. D.2016-12-15T11:10:38Z2016-12-15T11:10:38Z2016GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016.0304-4017https://www.arca.fiocruz.br/handle/icict/1653610.1016/j.vetpar.2016.04.0331873-2550engElsevierLipidiosMacrófagosLipidsBabesia bovisTLRGMacrophagesInvolvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Brasília. Instituto de Biologia. Departamento de Biologia Celular. Laboratório de Imunologia e Inflamação. Brasília, DF, Brasil.Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaToll like receptors (TLRs) are involved in the modulation of diverse host genes expression through a complex network of signalling events that allow for an appropriate response to a microbial pathogen. In the present work we used TLR6KO mice in order to study the role of TLR6 in the immune discrimination of lipids from two Babesia bovis strains, attenuated R1A (LA) and virulent S2P (LV), and the consequent macrophage activation. We demonstrated that TLR6 is required for lipid body induction in murine peritoneal macrophages by both LA and LV. Interestingly, as regards IL-10 and COX-2/PGE2 pathway induction by LA and LV, we observed differences in the biological effects produced by these lipid extracts. Our results indicate a role of TLR6 in the down-modulation of these immunoregulators only in the case of LA, whereas this receptor was not implicated in pro-inflammatory TNFα, IL-6 and KC release induced by LA. Remarkably, LV did not exert the down-modulatory effect observed for LA, supporting the notion that LA and LV possess different lipid composition that could correlate with the polar pathogenic effect of both B. bovis strains.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16536/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpt_bozza_etal_IOC_0216.pdfpt_bozza_etal_IOC_0216.pdfapplication/pdf769237https://www.arca.fiocruz.br/bitstream/icict/16536/2/pt_bozza_etal_IOC_0216.pdf79a9ce75aff53427912e0dfdd139bd0bMD52TEXTpt_bozza_etal_IOC_0216.pdf.txtpt_bozza_etal_IOC_0216.pdf.txtExtracted texttext/plain31908https://www.arca.fiocruz.br/bitstream/icict/16536/3/pt_bozza_etal_IOC_0216.pdf.txte6406628b17c0d649d0ce489d13a67c8MD53icict/165362018-08-15 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| dc.title.pt_BR.fl_str_mv |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| title |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| spellingShingle |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains Gimenez, G. Lipidios Macrófagos Lipids Babesia bovis TLRG Macrophages |
| title_short |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| title_full |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| title_fullStr |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| title_full_unstemmed |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| title_sort |
Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains |
| author |
Gimenez, G. |
| author_facet |
Gimenez, G. Belaunzarán, M. L. Magalhães, K .G. Poncini, C. V. Lammel, E. M. González Cappa, S. M. Bozza, P. T. Isola, E. L. D. |
| author_role |
author |
| author2 |
Belaunzarán, M. L. Magalhães, K .G. Poncini, C. V. Lammel, E. M. González Cappa, S. M. Bozza, P. T. Isola, E. L. D. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gimenez, G. Belaunzarán, M. L. Magalhães, K .G. Poncini, C. V. Lammel, E. M. González Cappa, S. M. Bozza, P. T. Isola, E. L. D. |
| dc.subject.other.pt_BR.fl_str_mv |
Lipidios Macrófagos |
| topic |
Lipidios Macrófagos Lipids Babesia bovis TLRG Macrophages |
| dc.subject.en.pt_BR.fl_str_mv |
Lipids Babesia bovis TLRG Macrophages |
| description |
Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, Argentina |
| publishDate |
2016 |
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2016-12-15T11:10:38Z |
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2016-12-15T11:10:38Z |
| dc.date.issued.fl_str_mv |
2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16536 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0304-4017 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.vetpar.2016.04.033 |
| dc.identifier.eissn.none.fl_str_mv |
1873-2550 |
| identifier_str_mv |
GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016. 0304-4017 10.1016/j.vetpar.2016.04.033 1873-2550 |
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Elsevier |
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