Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains

Detalhes bibliográficos
Autor(a) principal: Gimenez, G.
Data de Publicação: 2016
Outros Autores: Belaunzarán, M. L., Magalhães, K .G., Poncini, C. V., Lammel, E. M., González Cappa, S. M., Bozza, P. T., Isola, E. L. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16536
Resumo: Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, Argentina
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spelling Gimenez, G.Belaunzarán, M. L.Magalhães, K .G.Poncini, C. V.Lammel, E. M.González Cappa, S. M.Bozza, P. T.Isola, E. L. D.2016-12-15T11:10:38Z2016-12-15T11:10:38Z2016GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016.0304-4017https://www.arca.fiocruz.br/handle/icict/1653610.1016/j.vetpar.2016.04.0331873-2550engElsevierLipidiosMacrófagosLipidsBabesia bovisTLRGMacrophagesInvolvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Brasília. Instituto de Biologia. Departamento de Biologia Celular. Laboratório de Imunologia e Inflamação. Brasília, DF, Brasil.Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaUniversidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, ArgentinaToll like receptors (TLRs) are involved in the modulation of diverse host genes expression through a complex network of signalling events that allow for an appropriate response to a microbial pathogen. In the present work we used TLR6KO mice in order to study the role of TLR6 in the immune discrimination of lipids from two Babesia bovis strains, attenuated R1A (LA) and virulent S2P (LV), and the consequent macrophage activation. We demonstrated that TLR6 is required for lipid body induction in murine peritoneal macrophages by both LA and LV. Interestingly, as regards IL-10 and COX-2/PGE2 pathway induction by LA and LV, we observed differences in the biological effects produced by these lipid extracts. Our results indicate a role of TLR6 in the down-modulation of these immunoregulators only in the case of LA, whereas this receptor was not implicated in pro-inflammatory TNFα, IL-6 and KC release induced by LA. Remarkably, LV did not exert the down-modulatory effect observed for LA, supporting the notion that LA and LV possess different lipid composition that could correlate with the polar pathogenic effect of both B. bovis strains.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16536/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpt_bozza_etal_IOC_0216.pdfpt_bozza_etal_IOC_0216.pdfapplication/pdf769237https://www.arca.fiocruz.br/bitstream/icict/16536/2/pt_bozza_etal_IOC_0216.pdf79a9ce75aff53427912e0dfdd139bd0bMD52TEXTpt_bozza_etal_IOC_0216.pdf.txtpt_bozza_etal_IOC_0216.pdf.txtExtracted texttext/plain31908https://www.arca.fiocruz.br/bitstream/icict/16536/3/pt_bozza_etal_IOC_0216.pdf.txte6406628b17c0d649d0ce489d13a67c8MD53icict/165362018-08-15 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dc.title.pt_BR.fl_str_mv Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
title Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
spellingShingle Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
Gimenez, G.
Lipidios
Macrófagos
Lipids
Babesia bovis
TLRG
Macrophages
title_short Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
title_full Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
title_fullStr Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
title_full_unstemmed Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
title_sort Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains
author Gimenez, G.
author_facet Gimenez, G.
Belaunzarán, M. L.
Magalhães, K .G.
Poncini, C. V.
Lammel, E. M.
González Cappa, S. M.
Bozza, P. T.
Isola, E. L. D.
author_role author
author2 Belaunzarán, M. L.
Magalhães, K .G.
Poncini, C. V.
Lammel, E. M.
González Cappa, S. M.
Bozza, P. T.
Isola, E. L. D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gimenez, G.
Belaunzarán, M. L.
Magalhães, K .G.
Poncini, C. V.
Lammel, E. M.
González Cappa, S. M.
Bozza, P. T.
Isola, E. L. D.
dc.subject.other.pt_BR.fl_str_mv Lipidios
Macrófagos
topic Lipidios
Macrófagos
Lipids
Babesia bovis
TLRG
Macrophages
dc.subject.en.pt_BR.fl_str_mv Lipids
Babesia bovis
TLRG
Macrophages
description Universidade de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. CONICET. Facultad de Medicina. Buenos Aires, Argentina
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-15T11:10:38Z
dc.date.available.fl_str_mv 2016-12-15T11:10:38Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16536
dc.identifier.issn.pt_BR.fl_str_mv 0304-4017
dc.identifier.doi.none.fl_str_mv 10.1016/j.vetpar.2016.04.033
dc.identifier.eissn.none.fl_str_mv 1873-2550
identifier_str_mv GIMENEZ, G. et al. Involvement of TLR6 in the induction of COX-2, PGE2 and IL-10 in macrophages by lipids from virulent S2P and attenuated R1A Babesia bovis strains. Veterinary Parasitology, v.223, p.127-132, 2016.
0304-4017
10.1016/j.vetpar.2016.04.033
1873-2550
url https://www.arca.fiocruz.br/handle/icict/16536
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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