Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.

Detalhes bibliográficos
Autor(a) principal: Arruda, Maria da Gloria Bomfim
Data de Publicação: 2007
Outros Autores: Andrade, Bruno de Bezerril, Santos, Silvane, Clarêncio, Jorge, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7411
Resumo: Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
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spelling Arruda, Maria da Gloria BomfimAndrade, Bruno de BezerrilSantos, SilvaneClarêncio, JorgeBarral Netto, ManoelBarral, Aldina Maria Prado2014-03-17T17:07:05Z2014-03-17T17:07:05Z2007BOMFIM, G. et al. Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease. American Journal of Tropical Medicine Hygiene, v. 77, n. 5, p. 854–859, 2007.1476-1645https://www.arca.fiocruz.br/handle/icict/7411engThe American Society of Tropical Medicine and HygieneCellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilLymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites, and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early phase, N = 21) or lymphadenopathy and ulceration (late phase, N = 29). Early-phase patients exhibited a higher proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for IFN-gamma or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1-Th2 profile as well as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue damage.Leishmaniose Cutânea/patologiaLinfonodos/citologiaDoenças Linfáticas/patologiaAdolescenteAdultoCriançasHumanosFemininoMasculinoMeia-IdadePele/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBomfim G Cellular analysis....pdfBomfim G Cellular analysis....pdfapplication/pdf160243https://www.arca.fiocruz.br/bitstream/icict/7411/1/Bomfim%20G%20Cellular%20analysis....pdf7473c415ca2c57947a0d2f0c249d9e2dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7411/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBomfim G Cellular analysis....pdf.txtBomfim G Cellular analysis....pdf.txtExtracted texttext/plain30409https://www.arca.fiocruz.br/bitstream/icict/7411/5/Bomfim%20G%20Cellular%20analysis....pdf.txt5317db40a00c096bafa0df6797360ce8MD55THUMBNAILBomfim G Cellular analysis....pdf.jpgBomfim G Cellular analysis....pdf.jpgGenerated Thumbnailimage/jpeg1847https://www.arca.fiocruz.br/bitstream/icict/7411/4/Bomfim%20G%20Cellular%20analysis....pdf.jpg410e8d7e5b4ee24e80d9ba7cc1694122MD54icict/74112023-03-15 14:33:21.953oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
title Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
spellingShingle Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
Arruda, Maria da Gloria Bomfim
Leishmaniose Cutânea/patologia
Linfonodos/citologia
Doenças Linfáticas/patologia
Adolescente
Adulto
Crianças
Humanos
Feminino
Masculino
Meia-Idade
Pele/patologia
title_short Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
title_full Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
title_fullStr Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
title_full_unstemmed Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
title_sort Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
author Arruda, Maria da Gloria Bomfim
author_facet Arruda, Maria da Gloria Bomfim
Andrade, Bruno de Bezerril
Santos, Silvane
Clarêncio, Jorge
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Andrade, Bruno de Bezerril
Santos, Silvane
Clarêncio, Jorge
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arruda, Maria da Gloria Bomfim
Andrade, Bruno de Bezerril
Santos, Silvane
Clarêncio, Jorge
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Cutânea/patologia
Linfonodos/citologia
Doenças Linfáticas/patologia
Adolescente
Adulto
Crianças
Humanos
Feminino
Masculino
Meia-Idade
Pele/patologia
topic Leishmaniose Cutânea/patologia
Linfonodos/citologia
Doenças Linfáticas/patologia
Adolescente
Adulto
Crianças
Humanos
Feminino
Masculino
Meia-Idade
Pele/patologia
description Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-03-17T17:07:05Z
dc.date.available.fl_str_mv 2014-03-17T17:07:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOMFIM, G. et al. Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease. American Journal of Tropical Medicine Hygiene, v. 77, n. 5, p. 854–859, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7411
dc.identifier.issn.none.fl_str_mv 1476-1645
identifier_str_mv BOMFIM, G. et al. Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease. American Journal of Tropical Medicine Hygiene, v. 77, n. 5, p. 854–859, 2007.
1476-1645
url https://www.arca.fiocruz.br/handle/icict/7411
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv The American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv The American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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