The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells

Detalhes bibliográficos
Autor(a) principal: Maillard, Michel H.
Data de Publicação: 2007
Outros Autores: Almeida, Vinicius Cotta de, Takeshima, Fuminao, Nguyen, Deanna D., Michetti, Pierre, Nagler, Cathryn, Bhan, Atul K., Snapper, Scott B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41052
Resumo: Acesso aberto em 30/04/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118715/pdf/jem2040381.pdf
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spelling Maillard, Michel H.Almeida, Vinicius Cotta deTakeshima, FuminaoNguyen, Deanna D.Michetti, PierreNagler, CathrynBhan, Atul K.Snapper, Scott B.2020-04-30T19:54:52Z2020-04-30T19:54:52Z2007MAILLARD, Michel H. et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T. Journal of Experimental Medicine, v. 204, n. 3, p. 381-391, Feb. 2007.0022-1007https://www.arca.fiocruz.br/handle/icict/4105210.1084/jem.200613381540-9538Acesso aberto em 30/04/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118715/pdf/jem2040381.pdfMassachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Lausanne University Hospital. Department of Medicine. Division of Gastroenterology and Hepatology. Lausanne, Switzerland.Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA.Lausanne University Hospital. Department of Medicine. Division of Gastroenterology and Hepatology; Lausanne, Switzerland.. Massachusetts General Hospital. Division of Rheumatology. Boston, MA, USA / . Massachusetts General Hospital. Division of Allergy and Immunology. Boston, MA, USA / Harvard Medical School. Department of Medicine. Boston, MA, USA;Massachusetts General Hospital. Immunopathology Unit and the Center for the Study of Inflammatory Bowel Diseases. Boston, MA,USA / Harvard Medical Schoo. Department of Pathology. Boston, MA, USA.Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA / Harvard Medical School Department of Medicine. Boston, MA, USAThe Wiskott-Aldrich syndrome, a primary human immunodeficiency, results from defective expression of the hematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP). Because CD4(+)CD25(+)Foxp3(+) naturally occurring regulatory T (nTreg) cells control autoimmunity, we asked whether colitis in WASP knockout (WKO) mice is associated with aberrant development/function of nTreg cells. We show that WKO mice have decreased numbers of CD4(+)CD25(+)Foxp3(+) nTreg cells in both the thymus and peripheral lymphoid organs. Moreover, we demonstrate that WKO nTreg cells are markedly defective in both their ability to ameliorate the colitis induced by the transfer of CD45RB(hi) T cells and in functional suppression assays in vitro. Compared with wild-type (WT) nTreg cells, WKO nTreg cells show significantly impaired homing to both mucosal (mesenteric) and peripheral sites upon adoptive transfer into WT recipient mice. Suppression defects may be independent of antigen receptor-mediated actin rearrangement because both WT and WKO nTreg cells remodeled their actin cytoskeleton inefficiently upon T cell receptor stimulation. Preincubation of WKO nTreg cells with exogenous interleukin (IL)-2, combined with antigen receptor-mediated activation, substantially rescues the suppression defects. WKO nTreg cells are also defective in the secretion of the immunomodulatory cytokine IL-10. Overall, our data reveal a critical role for WASP in nTreg cell function and implicate nTreg cell dysfunction in the autoimmunity associated with WASP deficiency.engRockefeller University PressSíndrome de Wiskott-AldrichProteínaCélulas T reguladoras CD4+CD25+Foxp3+Wiskott-Aldrich syndromeProteinCD4+CD25+Foxp3+ regulatory T cellsThe Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
title The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
spellingShingle The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
Maillard, Michel H.
Síndrome de Wiskott-Aldrich
Proteína
Células T reguladoras CD4+CD25+Foxp3+
Wiskott-Aldrich syndrome
Protein
CD4+CD25+Foxp3+ regulatory T cells
title_short The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
title_full The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
title_fullStr The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
title_full_unstemmed The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
title_sort The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells
author Maillard, Michel H.
author_facet Maillard, Michel H.
Almeida, Vinicius Cotta de
Takeshima, Fuminao
Nguyen, Deanna D.
Michetti, Pierre
Nagler, Cathryn
Bhan, Atul K.
Snapper, Scott B.
author_role author
author2 Almeida, Vinicius Cotta de
Takeshima, Fuminao
Nguyen, Deanna D.
Michetti, Pierre
Nagler, Cathryn
Bhan, Atul K.
Snapper, Scott B.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maillard, Michel H.
Almeida, Vinicius Cotta de
Takeshima, Fuminao
Nguyen, Deanna D.
Michetti, Pierre
Nagler, Cathryn
Bhan, Atul K.
Snapper, Scott B.
dc.subject.other.pt_BR.fl_str_mv Síndrome de Wiskott-Aldrich
Proteína
Células T reguladoras CD4+CD25+Foxp3+
topic Síndrome de Wiskott-Aldrich
Proteína
Células T reguladoras CD4+CD25+Foxp3+
Wiskott-Aldrich syndrome
Protein
CD4+CD25+Foxp3+ regulatory T cells
dc.subject.en.pt_BR.fl_str_mv Wiskott-Aldrich syndrome
Protein
CD4+CD25+Foxp3+ regulatory T cells
description Acesso aberto em 30/04/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118715/pdf/jem2040381.pdf
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2020-04-30T19:54:52Z
dc.date.available.fl_str_mv 2020-04-30T19:54:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAILLARD, Michel H. et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T. Journal of Experimental Medicine, v. 204, n. 3, p. 381-391, Feb. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41052
dc.identifier.issn.pt_BR.fl_str_mv 0022-1007
dc.identifier.doi.none.fl_str_mv 10.1084/jem.20061338
dc.identifier.eissn.none.fl_str_mv 1540-9538
identifier_str_mv MAILLARD, Michel H. et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T. Journal of Experimental Medicine, v. 204, n. 3, p. 381-391, Feb. 2007.
0022-1007
10.1084/jem.20061338
1540-9538
url https://www.arca.fiocruz.br/handle/icict/41052
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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