TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56259 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciências e Projeto Tecnologia para Doenças Tropicais (INCT-DT). |
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Guerra, MarieleCarvalho, Natália B.Santos, SilvaneNascimento, Mauricio TSá, RenataCarvalho, Augusto M.Carvalho, Edgar M.Carvalho, Lucas P.2023-01-03T11:55:41Z2023-01-03T11:55:41Z2022GUERRA, Mariele et al. TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals. Frontiers in Immunology, p. 1-8, 20221664-3224https://www.arca.fiocruz.br/handle/icict/5625910.3389/fimmu.2022.954103Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciências e Projeto Tecnologia para Doenças Tropicais (INCT-DT).Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia, Complexo. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia, Complexo. Salvador, BA, Brasil.Universidade Estadual de Feira de Santana. Departamento de Biologia. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia, Complexo. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia, Complexo. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia - Doenças Tropicais. Conselho Nacional de Pesquisa. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia, Complexo. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia - Doenças Tropicais. Conselho Nacional de Pesquisa. Salvador, BA, Brasil.HTLV-1-infected individuals may develop a neurologic inflammatory condition known as HTLV-1-associated myelopathy (HAM/TSP), in which the high production of TNF is observed. These patients exhibit higher proviral loads, enhanced production of proinflammatory cytokines and lymphocyte proliferation in comparison to asymptomatic HTLV-1 carriers and those presenting overactive bladder (OAB-HTLV-infected). Metalloproteinases (MMPs) are known to degrade the components of the blood-brain barrier, favoring the migration of infected cells into the central nervous system. Moreover, the unbalanced production of MMPs and their inhibitors (TIMPs) has also been associated with tissue damage. The present work studied the production of MMP-9 and TIMPs in HTLV-1-infected individuals with and without neurological manifestations. HAM/TSP patients presented higher concentrations of MMP-9 in peripheral blood mononuclear cell (PBMC) culture supernatants, as well as a higher MMP-9/TIMP-3 ratio when compared to the other groups studied. MMP-9 levels positively correlated with proviral load and TNF in OAB-HTLV-infected individuals, and the in vitro neutralization of TNF significantly decreased MMP-9 levels in PBMC culture supernatants. Our findings indicate an association between MMP-9 production and the proinflammatory state associated with HTLV-1 infection, as well as HAM/TSP.engFrontiers MediaHTLV-1HAM/TSPMetaloproteinasesTIMPsInflamaçãoHTLV-1HAM/TSPMetalloproteinasesTIMPsInflammationHTLV-1MetaloproteasesInflamaçãoTNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56259/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGuerra, M. TNF-induced metalloproteinase-9 production is associated.pdfGuerra, M. TNF-induced metalloproteinase-9 production is associated.pdfapplication/pdf1494533https://www.arca.fiocruz.br/bitstream/icict/56259/2/Guerra%2c%20M.%20TNF-induced%20metalloproteinase-9%20production%20is%20associated.pdfe67f875b0bde24360d823a141af4fb80MD52icict/562592023-03-15 14:32:49.744oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| title |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| spellingShingle |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals Guerra, Mariele HTLV-1 HAM/TSP Metaloproteinases TIMPs Inflamação HTLV-1 HAM/TSP Metalloproteinases TIMPs Inflammation HTLV-1 Metaloproteases Inflamação |
| title_short |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| title_full |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| title_fullStr |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| title_full_unstemmed |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| title_sort |
TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals |
| author |
Guerra, Mariele |
| author_facet |
Guerra, Mariele Carvalho, Natália B. Santos, Silvane Nascimento, Mauricio T Sá, Renata Carvalho, Augusto M. Carvalho, Edgar M. Carvalho, Lucas P. |
| author_role |
author |
| author2 |
Carvalho, Natália B. Santos, Silvane Nascimento, Mauricio T Sá, Renata Carvalho, Augusto M. Carvalho, Edgar M. Carvalho, Lucas P. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Guerra, Mariele Carvalho, Natália B. Santos, Silvane Nascimento, Mauricio T Sá, Renata Carvalho, Augusto M. Carvalho, Edgar M. Carvalho, Lucas P. |
| dc.subject.other.en_US.fl_str_mv |
HTLV-1 HAM/TSP Metaloproteinases TIMPs Inflamação |
| topic |
HTLV-1 HAM/TSP Metaloproteinases TIMPs Inflamação HTLV-1 HAM/TSP Metalloproteinases TIMPs Inflammation HTLV-1 Metaloproteases Inflamação |
| dc.subject.en.en_US.fl_str_mv |
HTLV-1 HAM/TSP Metalloproteinases TIMPs Inflammation |
| dc.subject.decs.en_US.fl_str_mv |
HTLV-1 Metaloproteases Inflamação |
| description |
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciências e Projeto Tecnologia para Doenças Tropicais (INCT-DT). |
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2022 |
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2022 |
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2023-01-03T11:55:41Z |
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2023-01-03T11:55:41Z |
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GUERRA, Mariele et al. TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals. Frontiers in Immunology, p. 1-8, 2022 |
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https://www.arca.fiocruz.br/handle/icict/56259 |
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1664-3224 |
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10.3389/fimmu.2022.954103 |
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GUERRA, Mariele et al. TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals. Frontiers in Immunology, p. 1-8, 2022 1664-3224 10.3389/fimmu.2022.954103 |
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