On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13997 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia Ce |
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Jardim, Guilherme A. M.Reis, Wallace J.Ribeiro, Matheus F.Ottoni, Flaviano M.Alves, Ricardo J.Silva, Thaissa L.Goulart, Marilia O. F.Braga, Antonio L.Menna-Barreto, Rubem F. S.Salomão, KellyCastro, Solange L. deSilva Júnior, Eufrânio N. da2016-04-27T13:20:56Z2016-04-27T13:20:56Z2015JARDIM, Guilherme A. M. et al. On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity. RSC Adv., v.5, p.78047–78060, 2015.https://www.arca.fiocruz.br/handle/icict/1399710.1039/c5ra16213k2046-2069engRoyal Society of ChemistryOn the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia CeUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Farmácia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Farmácia. Belo Horizonte, MG, Brasil.Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia CeFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia CeFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia CeFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia CeIn our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic, triazole– carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold were prepared; in addition to electrochemical studies, these compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Among the thirty-eight compounds herein evaluated, six were found to be more potent against trypomastigotes than the standard drug benznidazole, with IC50/24 h values between 52.9 and 89.5 mM.Hybrid quinonesTrypanocidal activityChagas diseaseQuinonasTripanossomicidasDoença de Chagasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13997/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALkelly_salomão_etal_IOC_2015.pdfkelly_salomão_etal_IOC_2015.pdfapplication/pdf1493604https://www.arca.fiocruz.br/bitstream/icict/13997/2/kelly_salom%c3%a3o_etal_IOC_2015.pdfdfff0c13bf020d699151d4e2725b8f2aMD52TEXTkelly_salomão_etal_IOC_2015.pdf.txtkelly_salomão_etal_IOC_2015.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| title |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| spellingShingle |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity Jardim, Guilherme A. M. Hybrid quinones Trypanocidal activity Chagas disease Quinonas Tripanossomicidas Doença de Chagas |
| title_short |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| title_full |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| title_fullStr |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| title_full_unstemmed |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| title_sort |
On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity |
| author |
Jardim, Guilherme A. M. |
| author_facet |
Jardim, Guilherme A. M. Reis, Wallace J. Ribeiro, Matheus F. Ottoni, Flaviano M. Alves, Ricardo J. Silva, Thaissa L. Goulart, Marilia O. F. Braga, Antonio L. Menna-Barreto, Rubem F. S. Salomão, Kelly Castro, Solange L. de Silva Júnior, Eufrânio N. da |
| author_role |
author |
| author2 |
Reis, Wallace J. Ribeiro, Matheus F. Ottoni, Flaviano M. Alves, Ricardo J. Silva, Thaissa L. Goulart, Marilia O. F. Braga, Antonio L. Menna-Barreto, Rubem F. S. Salomão, Kelly Castro, Solange L. de Silva Júnior, Eufrânio N. da |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jardim, Guilherme A. M. Reis, Wallace J. Ribeiro, Matheus F. Ottoni, Flaviano M. Alves, Ricardo J. Silva, Thaissa L. Goulart, Marilia O. F. Braga, Antonio L. Menna-Barreto, Rubem F. S. Salomão, Kelly Castro, Solange L. de Silva Júnior, Eufrânio N. da |
| dc.subject.en.pt_BR.fl_str_mv |
Hybrid quinones Trypanocidal activity Chagas disease |
| topic |
Hybrid quinones Trypanocidal activity Chagas disease Quinonas Tripanossomicidas Doença de Chagas |
| dc.subject.decs.pt_BR.fl_str_mv |
Quinonas Tripanossomicidas Doença de Chagas |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Biologia Ce |
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2015 |
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2015 |
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2016-04-27T13:20:56Z |
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2016-04-27T13:20:56Z |
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info:eu-repo/semantics/article |
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JARDIM, Guilherme A. M. et al. On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity. RSC Adv., v.5, p.78047–78060, 2015. |
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https://www.arca.fiocruz.br/handle/icict/13997 |
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10.1039/c5ra16213k |
| dc.identifier.eissn.none.fl_str_mv |
2046-2069 |
| identifier_str_mv |
JARDIM, Guilherme A. M. et al. On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity. RSC Adv., v.5, p.78047–78060, 2015. 10.1039/c5ra16213k 2046-2069 |
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Royal Society of Chemistry |
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