Renin–angiotensin system contributes to naive T-cell migration in vivo

Detalhes bibliográficos
Autor(a) principal: Silva Filho, J. L.
Data de Publicação: 2015
Outros Autores: Souza, M. C., Henriques, M. G., Morrot, A., Savino, Wilson, Neves, C. Caruso, Pinheiro, A. A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12105
Resumo: 2016-04-30
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spelling Silva Filho, J. L.Souza, M. C.Henriques, M. G.Morrot, A.Savino, WilsonNeves, C. CarusoPinheiro, A. A. S.2015-11-03T13:10:04Z2016-05-01T07:30:06Z2015SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015.0003-9861https://www.arca.fiocruz.br/handle/icict/1210510.1016/j.abb.2015.02.0351096-0384engScienceDirectRenin–angiotensin system contributes to naive T-cell migration in vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-04-30Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT. Instituto Nacional de Ciência e Tecnologia em Biologia e Bioimagem. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasil.Angiotensin II (Ang II) plays an important role in the regulation of the T-cell response during inflammation. However, the cellular mechanisms underlying the regulation of lymphocytes under physiologic conditions have not yet been studied. Here, we tested the influence of Ang II on T-cell migration using T cells from BALB/c mice. The results obtained in vivo showed that when Ang II production or the AT1 receptor were blocked, T-cell counts were enhanced in blood but decreased in the spleen. The significance of these effects was confirmed by observing that these cells migrate, through fibronectin to Ang II via the AT1 receptor. We also observed a gradient of Ang II from peripheral blood to the spleen, which explains its chemotactic effect on this organ. The following cellular mechanisms were identified to mediate the Ang II effect: upregulation of the chemokine receptor CCR9; upregulation of the adhesion molecule CD62L; increased production of the chemokines CCL19 and CCL25 in the spleen. These results indicate that the higher levels of Ang II in the spleen and AT1 receptor activation contribute to migration of naive T cells to the spleen, which expands our understanding on how the Ang II/AT1 receptor axis contributes to adaptive immunity.Renin–angiotensin systemAngiotensin receptorsAdaptive immunityLymphoid organsChemokineQuimiocinasLinfóideSistema Renina-AngiotensinaReceptores de Angiotensinainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/12105/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALw_savino_etal_IOC_2015.pdfw_savino_etal_IOC_2015.pdfapplication/pdf3284078https://www.arca.fiocruz.br/bitstream/icict/12105/2/w_savino_etal_IOC_2015.pdfeac3d1b1d7bfb614faaac3420ae2f6d1MD52TEXTw_savino_etal_IOC_2015.pdf.txtw_savino_etal_IOC_2015.pdf.txtExtracted texttext/plain58113https://www.arca.fiocruz.br/bitstream/icict/12105/3/w_savino_etal_IOC_2015.pdf.txta2928cd9996e6bb81c8a87730546dc25MD53icict/121052023-09-14 16:01:53.486oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T19:01:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Renin–angiotensin system contributes to naive T-cell migration in vivo
title Renin–angiotensin system contributes to naive T-cell migration in vivo
spellingShingle Renin–angiotensin system contributes to naive T-cell migration in vivo
Silva Filho, J. L.
Renin–angiotensin system
Angiotensin receptors
Adaptive immunity
Lymphoid organs
Chemokine
Quimiocinas
Linfóide
Sistema Renina-Angiotensina
Receptores de Angiotensina
title_short Renin–angiotensin system contributes to naive T-cell migration in vivo
title_full Renin–angiotensin system contributes to naive T-cell migration in vivo
title_fullStr Renin–angiotensin system contributes to naive T-cell migration in vivo
title_full_unstemmed Renin–angiotensin system contributes to naive T-cell migration in vivo
title_sort Renin–angiotensin system contributes to naive T-cell migration in vivo
author Silva Filho, J. L.
author_facet Silva Filho, J. L.
Souza, M. C.
Henriques, M. G.
Morrot, A.
Savino, Wilson
Neves, C. Caruso
Pinheiro, A. A. S.
author_role author
author2 Souza, M. C.
Henriques, M. G.
Morrot, A.
Savino, Wilson
Neves, C. Caruso
Pinheiro, A. A. S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva Filho, J. L.
Souza, M. C.
Henriques, M. G.
Morrot, A.
Savino, Wilson
Neves, C. Caruso
Pinheiro, A. A. S.
dc.subject.en.pt_BR.fl_str_mv Renin–angiotensin system
Angiotensin receptors
Adaptive immunity
Lymphoid organs
Chemokine
topic Renin–angiotensin system
Angiotensin receptors
Adaptive immunity
Lymphoid organs
Chemokine
Quimiocinas
Linfóide
Sistema Renina-Angiotensina
Receptores de Angiotensina
dc.subject.decs.pt_BR.fl_str_mv Quimiocinas
Linfóide
Sistema Renina-Angiotensina
Receptores de Angiotensina
description 2016-04-30
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-11-03T13:10:04Z
dc.date.issued.fl_str_mv 2015
dc.date.available.fl_str_mv 2016-05-01T07:30:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12105
dc.identifier.issn.none.fl_str_mv 0003-9861
dc.identifier.doi.none.fl_str_mv 10.1016/j.abb.2015.02.035
dc.identifier.eissn.none.fl_str_mv 1096-0384
identifier_str_mv SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015.
0003-9861
10.1016/j.abb.2015.02.035
1096-0384
url https://www.arca.fiocruz.br/handle/icict/12105
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv ScienceDirect
publisher.none.fl_str_mv ScienceDirect
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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