The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates

Detalhes bibliográficos
Autor(a) principal: Secundino, Nágila Francinete Costa
Data de Publicação: 2012
Outros Autores: Freitas, Vanessa Cabreira de, Monteiro, Carolina Cunha, Pires, Ana Clara Araújo Machado, David, Bruna Araujo, Pimenta, Paulo Filemon Paolucci
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7944
Resumo: Fundação de Apoio a Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Tecnológico (CNPq), and Fundação Oswaldo Cruz (FIOCRUZ)
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spelling Secundino, Nágila Francinete CostaFreitas, Vanessa Cabreira deMonteiro, Carolina CunhaPires, Ana Clara Araújo MachadoDavid, Bruna AraujoPimenta, Paulo Filemon Paolucci2014-07-14T13:47:49Z2014-07-14T13:47:49Z2012SECUNDINO, Nagila Francinete Costa et al. The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates. Parasites & Vectors. 2012, vol.5, pp. 201756-3305https://www.arca.fiocruz.br/handle/icict/794410.1186/1756-3305-5-20Fundação de Apoio a Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Tecnológico (CNPq), and Fundação Oswaldo Cruz (FIOCRUZ)Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilBackground: Sandflies are vectors of Leishmania, the causative agent of leishmaniasis in mammalian hosts, including humans. The protozoan parasite is transmitted by the sandfly bite during salivation that occurs at the moment of blood feeding. The components of vector saliva include anticlotting and vasodilatory factors that facilitate blood flow and immunomodulatory factors that inhibit wound healing and quell the immune response. Not surprisingly, these factors also play important roles in the establishment of Leishmania infection. To date, the majority of knowledge that has been generated regarding the process of Leishmania infection, including L. infantum chagasi transmission has been gathered by using intradermal or subcutaneous inoculation of purified parasites. Findings: This study presents the establishment of a transmission model of Leishmania infantum chagasi by the bite of Lutzomyia longipalpis , the vector of American visceral leishmaniasis. The parasites were successfully transmitted by infected sandfly bites to mice and hamsters, indicating that both animals are good experimental models. The L. infantum chagasi dose that was transmitted in each single bite ranged from 10 to 10, 000 parasites, but 75% of the sandflies transmitted less than 300 parasites. Conclusions: The strategy for initiating infection by sandfly bite of experimental animals facilitates future investigations into the complex and dynamic mechanisms of visceral leishmaniasis. It is important to elucidate the transmission mechanism of vector bites. This model represents a useful tool to study L. infantum chagasi infection transmitted by the vector.engBiomed CentralThe transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebratesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletransmissionbiteleishmaniasisLutzomyia longipalpisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThe transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates.pdfThe transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates.pdfapplication/pdf864478https://www.arca.fiocruz.br/bitstream/icict/7944/1/The%20transmission%20of%20Leishmania%20infantum%20chagasi%20by%20the%20bite%20of%20the%20Lutzomyia%20longipalpis%20to%20two%20different%20vertebrates.pdf5e451886e0489310a585c4159e75b384MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7944/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTThe transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates.pdf.txtThe transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates.pdf.txtExtracted texttext/plain4https://www.arca.fiocruz.br/bitstream/icict/7944/3/The%20transmission%20of%20Leishmania%20infantum%20chagasi%20by%20the%20bite%20of%20the%20Lutzomyia%20longipalpis%20to%20two%20different%20vertebrates.pdf.txtff4c8ff01d544500ea4bfea43e6108c1MD53icict/79442018-10-11 15:07:12.736oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-10-11T18:07:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
title The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
spellingShingle The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
Secundino, Nágila Francinete Costa
transmission
bite
leishmaniasis
Lutzomyia longipalpis
title_short The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
title_full The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
title_fullStr The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
title_full_unstemmed The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
title_sort The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates
author Secundino, Nágila Francinete Costa
author_facet Secundino, Nágila Francinete Costa
Freitas, Vanessa Cabreira de
Monteiro, Carolina Cunha
Pires, Ana Clara Araújo Machado
David, Bruna Araujo
Pimenta, Paulo Filemon Paolucci
author_role author
author2 Freitas, Vanessa Cabreira de
Monteiro, Carolina Cunha
Pires, Ana Clara Araújo Machado
David, Bruna Araujo
Pimenta, Paulo Filemon Paolucci
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Secundino, Nágila Francinete Costa
Freitas, Vanessa Cabreira de
Monteiro, Carolina Cunha
Pires, Ana Clara Araújo Machado
David, Bruna Araujo
Pimenta, Paulo Filemon Paolucci
dc.subject.en.pt_BR.fl_str_mv transmission
bite
leishmaniasis
Lutzomyia longipalpis
topic transmission
bite
leishmaniasis
Lutzomyia longipalpis
description Fundação de Apoio a Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Tecnológico (CNPq), and Fundação Oswaldo Cruz (FIOCRUZ)
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-14T13:47:49Z
dc.date.available.fl_str_mv 2014-07-14T13:47:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SECUNDINO, Nagila Francinete Costa et al. The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates. Parasites & Vectors. 2012, vol.5, pp. 20
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7944
dc.identifier.issn.none.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/1756-3305-5-20
identifier_str_mv SECUNDINO, Nagila Francinete Costa et al. The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates. Parasites & Vectors. 2012, vol.5, pp. 20
1756-3305
10.1186/1756-3305-5-20
url https://www.arca.fiocruz.br/handle/icict/7944
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Biomed Central
publisher.none.fl_str_mv Biomed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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