Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11685 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Araujo, Natalia M.Araujo, Oscar C.Silva, Edinete M.Nogueira, Cristiane A. VillelaNabuco, Letícia C.Parana, RaymundoBessone, FernandoGomes, Selma A.Tiepo, ChristianKay, Alan2015-09-21T17:25:15Z2015-09-21T17:25:15Z2013ARAUJO, Natalia M.; et al. Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil. Journal of General Virology, v. 94, p.150–158, 2013.0022-1317https://www.arca.fiocruz.br/handle/icict/1168510.1099/vir.0.047324-0engSociety for General MicrobiologyBrasilSoropositividadeHepatitis BGenotypes F and GHuman ImmunodeficiencyArgentinaBrazilVirus-positive patientsVírus da Hepatite BImunodeficiência HumanaIdentification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Hepato-Gastroenterologia. Salvador, BA, Brasil.University of Rosario. School of Medicine. Department of Gastroenterology and Hepatology. Rosario, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a coinfecting HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent in both patients, with .99% of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11685/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALnatalia_araujo_etal_IOC_2013.pdfapplication/pdf902148https://www.arca.fiocruz.br/bitstream/icict/11685/2/natalia_araujo_etal_IOC_2013.pdf0b088cd811d56ef6881aec7974d6abecMD52TEXTnatalia_araujo_etal_IOC_2013.pdf.txtnatalia_araujo_etal_IOC_2013.pdf.txtExtracted texttext/plain36717https://www.arca.fiocruz.br/bitstream/icict/11685/3/natalia_araujo_etal_IOC_2013.pdf.txtb143345c16882ee9c5f7b1e60876e002MD53icict/116852022-06-24 12:17:35.679oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| title |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| spellingShingle |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil Araujo, Natalia M. Brasil Soropositividade Hepatitis B Genotypes F and G Human Immunodeficiency Argentina Brazil Virus-positive patients Vírus da Hepatite B Imunodeficiência Humana |
| title_short |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| title_full |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| title_fullStr |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| title_full_unstemmed |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| title_sort |
Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil |
| author |
Araujo, Natalia M. |
| author_facet |
Araujo, Natalia M. Araujo, Oscar C. Silva, Edinete M. Nogueira, Cristiane A. Villela Nabuco, Letícia C. Parana, Raymundo Bessone, Fernando Gomes, Selma A. Tiepo, Christian Kay, Alan |
| author_role |
author |
| author2 |
Araujo, Oscar C. Silva, Edinete M. Nogueira, Cristiane A. Villela Nabuco, Letícia C. Parana, Raymundo Bessone, Fernando Gomes, Selma A. Tiepo, Christian Kay, Alan |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araujo, Natalia M. Araujo, Oscar C. Silva, Edinete M. Nogueira, Cristiane A. Villela Nabuco, Letícia C. Parana, Raymundo Bessone, Fernando Gomes, Selma A. Tiepo, Christian Kay, Alan |
| dc.subject.other.pt_BR.fl_str_mv |
Brasil Soropositividade |
| topic |
Brasil Soropositividade Hepatitis B Genotypes F and G Human Immunodeficiency Argentina Brazil Virus-positive patients Vírus da Hepatite B Imunodeficiência Humana |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B Genotypes F and G Human Immunodeficiency Argentina Brazil Virus-positive patients |
| dc.subject.decs.pt_BR.fl_str_mv |
Vírus da Hepatite B Imunodeficiência Humana |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2015-09-21T17:25:15Z |
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2015-09-21T17:25:15Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ARAUJO, Natalia M.; et al. Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil. Journal of General Virology, v. 94, p.150–158, 2013. |
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https://www.arca.fiocruz.br/handle/icict/11685 |
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0022-1317 |
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10.1099/vir.0.047324-0 |
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ARAUJO, Natalia M.; et al. Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil. Journal of General Virology, v. 94, p.150–158, 2013. 0022-1317 10.1099/vir.0.047324-0 |
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