Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28564 |
Resumo: | Ministério da Saúde do Brasil / Programa DST / AIDS / UNESCO (CSV 182/06 - Projeto "Estudo Clínico-Epidemiológico da Co-Infecção HIV / Tuberculose em Recife"). Os autores foram parcialmente apoiados pelo CNPq (bolsa 308311 / 2009-4 para RAAX e bolsa 301779 / 2009-0 para MFPMA e bolsa 310911 / 2009-5 para HRL). |
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Maruza, MagdaAlbuquerque, Maria F. P. MilitãoCoimbra, IsabellaMoura, Líbia V.Montarroyos, Ulisses R.Miranda Filho, Demócrito B.Lacerda, Heloísa R.Rodrigues, Laura C.Ximenes, Ricardo A. A.2018-09-05T12:15:05Z2018-09-05T12:15:05Z2011MARUZA, M. et al. Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study. BMC infectious diseases, v. 11, p. 351, 16 dez. 2011.1471-2334https://www.arca.fiocruz.br/handle/icict/2856410.1186/1471-2334-11-351Ministério da Saúde do Brasil / Programa DST / AIDS / UNESCO (CSV 182/06 - Projeto "Estudo Clínico-Epidemiológico da Co-Infecção HIV / Tuberculose em Recife"). Os autores foram parcialmente apoiados pelo CNPq (bolsa 308311 / 2009-4 para RAAX e bolsa 301779 / 2009-0 para MFPMA e bolsa 310911 / 2009-5 para HRL).Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento NESC. Recife, PE, Brasil.Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil.Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil.Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil.Universidade de Pernambuco. Department of Medical Science. Recife, PE, Brasil.Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil.London School of Hygiene and Tropical Medicine. London, UK.Universidade Federal de Pernambuco. Department of Tropical Medicine. Recife, PE, Brasil / Universidade de Pernambuco. Department of Medical Science. Recife, PE, Brasil.BACKGROUND: Concomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series of challenges for treatment compliance for both providers and patients. We carried out this study to identify risk factors for default from TB treatment in people living with HIV. METHODS: We conducted a cohort study to monitor HIV/TB co-infected subjects in Pernambuco, Brazil, on a monthly basis, until completion or default of treatment for TB. Logistic regression was used to calculate crude and adjusted odds ratios, 95% confidence intervals and P-values. RESULTS: From a cohort of 2310 HIV subjects, 390 individuals (16.9%) who had started treatment after a diagnosis of TB were selected, and data on 273 individuals who completed or defaulted on treatment for TB were analyzed. The default rate was 21.7% and the following risk factors were identified: male gender, smoking and CD4 T-cell count less than 200 cells/mm3. Age over 29 years, complete or incomplete secondary or university education and the use of highly active antiretroviral therapy (HAART) were identified as protective factors for the outcome. CONCLUSION: The results point to the need for more specific actions, aiming to reduce the default from TB treatment in males, younger adults with low education, smokers and people with CD4 T-cell counts < 200 cells/mm3. Default was less likely to occur in patients under HAART, reinforcing the strategy of early initiation of HAART in individuals with TB.engVírus da imunodeficiência humanaPaciente com Vírus da Imunodeficiência HumanaTerapia de observação diretaModelo Multivariado FinalPadrão de tratamentoHuman Immunodeficiency VirusHuman Immunodeficiency Virus PatientDirectly Observe TherapyFinal Multivariate ModelTreatment DefaultInfecções Oportunistas Relacionadas com a AIDS / quimioterapiaInfecções Oportunistas Relacionadas com a AIDS / epidemiologiaTerapia Antirretroviral de Alta AtividadeBrasilContagem de linfócitos CD4Status educacionalInfecções por HIV / complicaçõesInfecções por HIV / quimioterapiaConformidade do pacienteEstudos ProspectivosFatores de RiscoFatores SexuaisTuberculose / complicaçõesTuberculose / quimioterapiaTuberculose / epidemiologiaAdulto jovemFumarInfecções por HIV / epidemiologiaRisk factors for default from tuberculosis treatment in HIV-infected individuals in the state of 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| dc.title.pt_BR.fl_str_mv |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| title |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| spellingShingle |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study Maruza, Magda Vírus da imunodeficiência humana Paciente com Vírus da Imunodeficiência Humana Terapia de observação direta Modelo Multivariado Final Padrão de tratamento Human Immunodeficiency Virus Human Immunodeficiency Virus Patient Directly Observe Therapy Final Multivariate Model Treatment Default Infecções Oportunistas Relacionadas com a AIDS / quimioterapia Infecções Oportunistas Relacionadas com a AIDS / epidemiologia Terapia Antirretroviral de Alta Atividade Brasil Contagem de linfócitos CD4 Status educacional Infecções por HIV / complicações Infecções por HIV / quimioterapia Conformidade do paciente Estudos Prospectivos Fatores de Risco Fatores Sexuais Tuberculose / complicações Tuberculose / quimioterapia Tuberculose / epidemiologia Adulto jovem Fumar Infecções por HIV / epidemiologia |
| title_short |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| title_full |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| title_fullStr |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| title_full_unstemmed |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| title_sort |
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study |
| author |
Maruza, Magda |
| author_facet |
Maruza, Magda Albuquerque, Maria F. P. Militão Coimbra, Isabella Moura, Líbia V. Montarroyos, Ulisses R. Miranda Filho, Demócrito B. Lacerda, Heloísa R. Rodrigues, Laura C. Ximenes, Ricardo A. A. |
| author_role |
author |
| author2 |
Albuquerque, Maria F. P. Militão Coimbra, Isabella Moura, Líbia V. Montarroyos, Ulisses R. Miranda Filho, Demócrito B. Lacerda, Heloísa R. Rodrigues, Laura C. Ximenes, Ricardo A. A. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Maruza, Magda Albuquerque, Maria F. P. Militão Coimbra, Isabella Moura, Líbia V. Montarroyos, Ulisses R. Miranda Filho, Demócrito B. Lacerda, Heloísa R. Rodrigues, Laura C. Ximenes, Ricardo A. A. |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da imunodeficiência humana Paciente com Vírus da Imunodeficiência Humana Terapia de observação direta Modelo Multivariado Final Padrão de tratamento |
| topic |
Vírus da imunodeficiência humana Paciente com Vírus da Imunodeficiência Humana Terapia de observação direta Modelo Multivariado Final Padrão de tratamento Human Immunodeficiency Virus Human Immunodeficiency Virus Patient Directly Observe Therapy Final Multivariate Model Treatment Default Infecções Oportunistas Relacionadas com a AIDS / quimioterapia Infecções Oportunistas Relacionadas com a AIDS / epidemiologia Terapia Antirretroviral de Alta Atividade Brasil Contagem de linfócitos CD4 Status educacional Infecções por HIV / complicações Infecções por HIV / quimioterapia Conformidade do paciente Estudos Prospectivos Fatores de Risco Fatores Sexuais Tuberculose / complicações Tuberculose / quimioterapia Tuberculose / epidemiologia Adulto jovem Fumar Infecções por HIV / epidemiologia |
| dc.subject.en.pt_BR.fl_str_mv |
Human Immunodeficiency Virus Human Immunodeficiency Virus Patient Directly Observe Therapy Final Multivariate Model Treatment Default |
| dc.subject.decs.pt_BR.fl_str_mv |
Infecções Oportunistas Relacionadas com a AIDS / quimioterapia Infecções Oportunistas Relacionadas com a AIDS / epidemiologia Terapia Antirretroviral de Alta Atividade Brasil Contagem de linfócitos CD4 Status educacional Infecções por HIV / complicações Infecções por HIV / quimioterapia Conformidade do paciente Estudos Prospectivos Fatores de Risco Fatores Sexuais Tuberculose / complicações Tuberculose / quimioterapia Tuberculose / epidemiologia Adulto jovem Fumar Infecções por HIV / epidemiologia |
| description |
Ministério da Saúde do Brasil / Programa DST / AIDS / UNESCO (CSV 182/06 - Projeto "Estudo Clínico-Epidemiológico da Co-Infecção HIV / Tuberculose em Recife"). Os autores foram parcialmente apoiados pelo CNPq (bolsa 308311 / 2009-4 para RAAX e bolsa 301779 / 2009-0 para MFPMA e bolsa 310911 / 2009-5 para HRL). |
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2011 |
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2011 |
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2018-09-05T12:15:05Z |
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2018-09-05T12:15:05Z |
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MARUZA, M. et al. Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study. BMC infectious diseases, v. 11, p. 351, 16 dez. 2011. |
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https://www.arca.fiocruz.br/handle/icict/28564 |
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1471-2334 |
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10.1186/1471-2334-11-351 |
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MARUZA, M. et al. Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study. BMC infectious diseases, v. 11, p. 351, 16 dez. 2011. 1471-2334 10.1186/1471-2334-11-351 |
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