Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.

Detalhes bibliográficos
Autor(a) principal: Lanzaro, G. C
Data de Publicação: 1999
Outros Autores: Lopes, Angela Hampshire de Carvalho Santos, Ribeiro, José Marcos Chaves, Shoemaker, Charles B, Warburg, A, Soares, Milena Botelho Pereira, Titus, Richard G
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9909
Resumo: University of Texas Medical Branch. University Boulevard. Department of Pathology & Center for Tropical Diseases. Galveston, USA
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spelling Lanzaro, G. CLopes, Angela Hampshire de Carvalho SantosRibeiro, José Marcos ChavesShoemaker, Charles BWarburg, ASoares, Milena Botelho PereiraTitus, Richard G2015-04-07T14:02:23Z2015-04-07T14:02:23Z1999LANZARO, G. C. et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Molecular Biology, v. 8, n. 2, p. 267-275, 1999.0962-1075https://www.arca.fiocruz.br/handle/icict/9909engBlackwell ScienceVariation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Texas Medical Branch. University Boulevard. Department of Pathology & Center for Tropical Diseases. Galveston, USAUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, BrasilNational Institute for Health and Welfare. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USAHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAHebrew University-Hadassah Medical School. Ein Kerem, Jerusalem, IsraelFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilColorado State University. College of Veterinary Medicine & Biomedical Sciences. Fort Collins, CO, USAMaxadilan is an approximately 7kDa peptide that occurs in the saliva of the sand fly Lutzomyia longipalpis. This peptide is a potent vasodilator and may also have immunomodulatory effects related to the pathogenesis of leishmanial infections. Variation in the primary DNA and inferred amino acid sequence of maxadilan is reported. Differences were found within and among natural field populations as well as among sibling species. Extensive amino acid sequence differentiation, up to 23%, was observed among maxadilan from different populations. This is a remarkable degree of polymorphism considering the small size of this peptide. The vasodilatory activity of maxadilan was equivalent among recombinant maxadilan variants. All maxadilan variants induce interleukin-6. Predicted secondary structure and hydrophobicity plots suggest that these characteristics are conserved among variant peptides. However, profiles based on the antigenic index do differ among peptides.MaxadalinPopulation geneticsSalivaVasodilatorProteínas de Insetos/farmacologiaPsychodidaeProteínas e Peptídeos Salivares/farmacologiaVasodilatadores/farmacologiaAnimaisSequência de BasesDNAProteínas de Insetos/químicaInterleucina-6/biossínteseMacrófagos Peritoneais/efeitos de drogasDados de Sequência MolecularEstrutura Secundária de ProteínaCoelhosProteínas e Peptídeos Salivares/químicaVasodilatadores/químicaVasodilatadores/classificaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9909/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALLanzaro GC Variation....pdfLanzaro GC Variation....pdfapplication/pdf1322465https://www.arca.fiocruz.br/bitstream/icict/9909/2/Lanzaro%20GC%20Variation....pdfa7482db4964cace69ffd751e35af1d15MD52TEXTLanzaro GC Variation....pdf.txtLanzaro GC Variation....pdf.txtExtracted texttext/plain9https://www.arca.fiocruz.br/bitstream/icict/9909/3/Lanzaro%20GC%20Variation....pdf.txt33f4f15a16a9843faf6a25d4f387b6fdMD53icict/99092023-03-15 14:33:22.741oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
title Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
spellingShingle Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
Lanzaro, G. C
Maxadalin
Population genetics
Saliva
Vasodilator
Proteínas de Insetos/farmacologia
Psychodidae
Proteínas e Peptídeos Salivares/farmacologia
Vasodilatadores/farmacologia
Animais
Sequência de Bases
DNA
Proteínas de Insetos/química
Interleucina-6/biossíntese
Macrófagos Peritoneais/efeitos de drogas
Dados de Sequência Molecular
Estrutura Secundária de Proteína
Coelhos
Proteínas e Peptídeos Salivares/química
Vasodilatadores/química
Vasodilatadores/classificação
title_short Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
title_full Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
title_fullStr Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
title_full_unstemmed Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
title_sort Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex.
author Lanzaro, G. C
author_facet Lanzaro, G. C
Lopes, Angela Hampshire de Carvalho Santos
Ribeiro, José Marcos Chaves
Shoemaker, Charles B
Warburg, A
Soares, Milena Botelho Pereira
Titus, Richard G
author_role author
author2 Lopes, Angela Hampshire de Carvalho Santos
Ribeiro, José Marcos Chaves
Shoemaker, Charles B
Warburg, A
Soares, Milena Botelho Pereira
Titus, Richard G
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lanzaro, G. C
Lopes, Angela Hampshire de Carvalho Santos
Ribeiro, José Marcos Chaves
Shoemaker, Charles B
Warburg, A
Soares, Milena Botelho Pereira
Titus, Richard G
dc.subject.en.pt_BR.fl_str_mv Maxadalin
Population genetics
Saliva
Vasodilator
topic Maxadalin
Population genetics
Saliva
Vasodilator
Proteínas de Insetos/farmacologia
Psychodidae
Proteínas e Peptídeos Salivares/farmacologia
Vasodilatadores/farmacologia
Animais
Sequência de Bases
DNA
Proteínas de Insetos/química
Interleucina-6/biossíntese
Macrófagos Peritoneais/efeitos de drogas
Dados de Sequência Molecular
Estrutura Secundária de Proteína
Coelhos
Proteínas e Peptídeos Salivares/química
Vasodilatadores/química
Vasodilatadores/classificação
dc.subject.decs.pt_BR.fl_str_mv Proteínas de Insetos/farmacologia
Psychodidae
Proteínas e Peptídeos Salivares/farmacologia
Vasodilatadores/farmacologia
Animais
Sequência de Bases
DNA
Proteínas de Insetos/química
Interleucina-6/biossíntese
Macrófagos Peritoneais/efeitos de drogas
Dados de Sequência Molecular
Estrutura Secundária de Proteína
Coelhos
Proteínas e Peptídeos Salivares/química
Vasodilatadores/química
Vasodilatadores/classificação
description University of Texas Medical Branch. University Boulevard. Department of Pathology & Center for Tropical Diseases. Galveston, USA
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2015-04-07T14:02:23Z
dc.date.available.fl_str_mv 2015-04-07T14:02:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LANZARO, G. C. et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Molecular Biology, v. 8, n. 2, p. 267-275, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9909
dc.identifier.issn.none.fl_str_mv 0962-1075
identifier_str_mv LANZARO, G. C. et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Molecular Biology, v. 8, n. 2, p. 267-275, 1999.
0962-1075
url https://www.arca.fiocruz.br/handle/icict/9909
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Science
publisher.none.fl_str_mv Blackwell Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/9909/2/Lanzaro%20GC%20Variation....pdf
https://www.arca.fiocruz.br/bitstream/icict/9909/3/Lanzaro%20GC%20Variation....pdf.txt
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