High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.2147/DMSO.S211253 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40971 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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Silvares, Raquel RangelPereira, Evelyn Nunes Goulart da SilvaFlores, Edgar Eduardo IlaquitaRodrigues, Karine LinoSilva, Adriana RibeiroAlbuquerque, Cassiano Felipe Gonçalves deDaliry, Anissa2020-04-26T20:17:28Z2020-04-26T20:17:28Z2019SILVARES, Raquel Rangel et al. High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 1773-1781, 2019.1178-7007https://www.arca.fiocruz.br/handle/icict/4097110.2147/DMSO.S2112531178-7007engDove Medical PressSíndrome metabólicaAvançado produtos finais de glicaçãoPiridoxaminaDisfunção endotelial renalMetabolic syndromeKidney endothelial dysfunctionPyridoxamineAdvanced glycation end productsHigh-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defenseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunifarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunifarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Introduction: This study aimed to investigate changes in renal function and the AGERAGE axis in the kidney of a non-genetic animal model of metabolic syndrome (MetS) induced by high-fat diet (HFD). Additionally, we evaluated the protective effect of pyridoxamine (PM), a vitamin B6 analog with anti-AGE effects, in the context of diet-related renal endothelial dysfunction. Methodology: In Wistar rats, the MetS animal model was induced by 20 or 28 weeks of HFD feeding. When indicated, a subgroup of animals was treated daily with PM (60 mg/kg) for 2 months. Tissue perfusion in renal microcirculation was examined by laser speckle contrast imaging. Oxidative stress was analyzed by thiobarbituric acid reactive species and the inflammatory markers by ELISA (TNF-α and IL-1β). Reverse transcription polymerase chain reaction was used to analyze eNOs, IL-6, vascular cell adhesion molecule (VCAM), NADPH oxidase subunit 47 (N47), catalase, and receptor for AGE (RAGE) gene expression. Results: Wistar rats fed a HFD showed negligible alteration in renal function, decrease in catalase mRNA transcripts and catalase enzyme activity compared to control (CTL) animals. Increased levels of IL-1β were observed in the kidney of MetS-induced rats. HFD-fed rats exhibited kidney endothelial dysfunction, with no significant differences in basal microvascular blood flow. PM significantly improved kidney vasorelaxation in HFD-fed rats. eNOS, VCAM, and RAGE gene expression and AGE content were not altered in kidneys of HFDinduced MetS rats in comparison to CTLs. Conclusions: Our findings suggest that HFD-induced microvascular dysfunction precedes the decline in renal function, and could be related to antioxidant machinery defects and inflammation activation in the kidney. PM showed a vasoprotective effect, and thus, could be an important contributory factor in ameliorating diet-induced renal damage.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40971/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlissaDaliry_RaquelSIlvaresètal_IOC_2019.pdfAlissaDaliry_RaquelSIlvaresètal_IOC_2019.pdfapplication/pdf2197961https://www.arca.fiocruz.br/bitstream/icict/40971/2/AlissaDaliry_RaquelSIlvares%c3%a8tal_IOC_2019.pdf1504deffc1b7ade8da839c1279bdf619MD52TEXTAlissaDaliry_RaquelSIlvaresètal_IOC_2019.pdf.txtAlissaDaliry_RaquelSIlvaresètal_IOC_2019.pdf.txtExtracted texttext/plain36850https://www.arca.fiocruz.br/bitstream/icict/40971/3/AlissaDaliry_RaquelSIlvares%c3%a8tal_IOC_2019.pdf.txt5a9a2395b980c0aef51be31fcb900deaMD53icict/409712020-04-30 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| dc.title.pt_BR.fl_str_mv |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| title |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| spellingShingle |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense Silvares, Raquel Rangel Síndrome metabólica Avançado produtos finais de glicação Piridoxamina Disfunção endotelial renal Metabolic syndrome Kidney endothelial dysfunction Pyridoxamine Advanced glycation end products |
| title_short |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| title_full |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| title_fullStr |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| title_full_unstemmed |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| title_sort |
High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense |
| author |
Silvares, Raquel Rangel |
| author_facet |
Silvares, Raquel Rangel Pereira, Evelyn Nunes Goulart da Silva Flores, Edgar Eduardo Ilaquita Rodrigues, Karine Lino Silva, Adriana Ribeiro Albuquerque, Cassiano Felipe Gonçalves de Daliry, Anissa |
| author_role |
author |
| author2 |
Pereira, Evelyn Nunes Goulart da Silva Flores, Edgar Eduardo Ilaquita Rodrigues, Karine Lino Silva, Adriana Ribeiro Albuquerque, Cassiano Felipe Gonçalves de Daliry, Anissa |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silvares, Raquel Rangel Pereira, Evelyn Nunes Goulart da Silva Flores, Edgar Eduardo Ilaquita Rodrigues, Karine Lino Silva, Adriana Ribeiro Albuquerque, Cassiano Felipe Gonçalves de Daliry, Anissa |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome metabólica Avançado produtos finais de glicação Piridoxamina Disfunção endotelial renal |
| topic |
Síndrome metabólica Avançado produtos finais de glicação Piridoxamina Disfunção endotelial renal Metabolic syndrome Kidney endothelial dysfunction Pyridoxamine Advanced glycation end products |
| dc.subject.en.pt_BR.fl_str_mv |
Metabolic syndrome Kidney endothelial dysfunction Pyridoxamine Advanced glycation end products |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2019 |
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2019 |
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2020-04-26T20:17:28Z |
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2020-04-26T20:17:28Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVARES, Raquel Rangel et al. High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 1773-1781, 2019. |
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https://www.arca.fiocruz.br/handle/icict/40971 |
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1178-7007 |
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10.2147/DMSO.S211253 |
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1178-7007 |
| identifier_str_mv |
SILVARES, Raquel Rangel et al. High-fat diet-induced kidney alterations in rats with metabolic syndrome: endothelial dysfunction and decreased antioxidant defense. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 1773-1781, 2019. 1178-7007 10.2147/DMSO.S211253 |
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Dove Medical Press |
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Dove Medical Press |
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