Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17879 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. |
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Martins, Darliane A.Bomfim Filho, Lucius F.Silva, Cleiton M. daFátima, Ângelo deLouro, Sonia R. W.Batista, Denise G. J.Soeiro, Maria de Nazaré C.Carvalho, João Ernesto deTeixeira, Letícia R.2017-02-21T17:26:39Z2017-02-21T17:26:39Z2016MARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017.0103-5053https://www.arca.fiocruz.br/handle/icict/1787910.5935/0103-5053.201601501678-4790engInstituto de Química - UNICAMPAlbuminasBase de schiffComplexos de cobre (II)DNAAtividade biológicaSchiff basecopper(II) complexesbiological activityDNAalbuminCopper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albuminsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Campinas, SP, Brasil.Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino) phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17879/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarianazare2_soeiro_etal_IOC_2016.pdfmarianazare2_soeiro_etal_IOC_2016.pdfapplication/pdf767152https://www.arca.fiocruz.br/bitstream/icict/17879/2/marianazare2_soeiro_etal_IOC_2016.pdff32ce4acf41e59b1c19fa54460e1a094MD52TEXTmarianazare2_soeiro_etal_IOC_2016.pdf.txtmarianazare2_soeiro_etal_IOC_2016.pdf.txtExtracted texttext/plain41368https://www.arca.fiocruz.br/bitstream/icict/17879/3/marianazare2_soeiro_etal_IOC_2016.pdf.txtd40e0e4b3d247e76c027c388a954fc10MD53icict/178792023-09-14 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| dc.title.pt_BR.fl_str_mv |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| title |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| spellingShingle |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins Martins, Darliane A. Albuminas Base de schiff Complexos de cobre (II) DNA Atividade biológica Schiff base copper(II) complexes biological activity DNA albumin |
| title_short |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| title_full |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| title_fullStr |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| title_full_unstemmed |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| title_sort |
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins |
| author |
Martins, Darliane A. |
| author_facet |
Martins, Darliane A. Bomfim Filho, Lucius F. Silva, Cleiton M. da Fátima, Ângelo de Louro, Sonia R. W. Batista, Denise G. J. Soeiro, Maria de Nazaré C. Carvalho, João Ernesto de Teixeira, Letícia R. |
| author_role |
author |
| author2 |
Bomfim Filho, Lucius F. Silva, Cleiton M. da Fátima, Ângelo de Louro, Sonia R. W. Batista, Denise G. J. Soeiro, Maria de Nazaré C. Carvalho, João Ernesto de Teixeira, Letícia R. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Martins, Darliane A. Bomfim Filho, Lucius F. Silva, Cleiton M. da Fátima, Ângelo de Louro, Sonia R. W. Batista, Denise G. J. Soeiro, Maria de Nazaré C. Carvalho, João Ernesto de Teixeira, Letícia R. |
| dc.subject.other.pt_BR.fl_str_mv |
Albuminas Base de schiff Complexos de cobre (II) DNA Atividade biológica |
| topic |
Albuminas Base de schiff Complexos de cobre (II) DNA Atividade biológica Schiff base copper(II) complexes biological activity DNA albumin |
| dc.subject.en.pt_BR.fl_str_mv |
Schiff base copper(II) complexes biological activity DNA albumin |
| description |
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2017-02-21T17:26:39Z |
| dc.date.available.fl_str_mv |
2017-02-21T17:26:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
MARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017. |
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https://www.arca.fiocruz.br/handle/icict/17879 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0103-5053 |
| dc.identifier.doi.none.fl_str_mv |
10.5935/0103-5053.20160150 |
| dc.identifier.eissn.none.fl_str_mv |
1678-4790 |
| identifier_str_mv |
MARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017. 0103-5053 10.5935/0103-5053.20160150 1678-4790 |
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openAccess |
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Instituto de Química - UNICAMP |
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Instituto de Química - UNICAMP |
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