Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/21003 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Paiva, Marcelo H. S.Lovin, Diane D.Mori, AkioMelo-Santos, Maria A. V.Severson, David W.Ayres, Constância F. J.2017-09-13T17:43:33Z2017-09-13T17:43:33Z2016PAIVA, M. H. S. et al. Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti. Genomics, v. 107, n. 1, p. 40–48, jan. 2016.1089-8646https://www.arca.fiocruz.br/handle/icict/2100310.1016/j.ygeno.2015.11.004porAedesResistência a InseticidasLocos de Características QuantitativasAedesdrug effectsgeneticsAnimalsChromosomes, InsectInsecticide ResistanceInsecticidesQuantitative Trait LociTemefostoxicityAedesAnimaisCromossomos de InsetosResistência a InseticidasInseticidasLocos de Características QuantitativasTemefósIdentification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegyptiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilOrganophosphate insecticides (OP) have extensively been used to control mosquitoes, such as the vector Aedes aegypti. Unfortunately, OP resistance has hampered control programs worldwide. We used Quantitative Trait Locus (QTL) mapping to evaluate temephos resistance in two F1 intercross populations derived from crosses between a resistant Ae. aegypti strain (RecR) and two susceptible strains (MoyoD and Red). A single major effect QTL was identified on chromosome 2 of both segregating populations, named rtt1 (resistance to temephos 1). Bioinformatics analyses identified a cluster of carboxylesterase genes (CCE) within the rtt1 interval. qRT-PCR demonstrated that different CCEs were up-regulated in F2 resistant individuals from both crosses. However, none exceeded the 2-fold expression. Primary mechanisms for temephos resistance may vary between Ae. aegypti populations, yet also appear to support previous findings suggesting that multiple linked esterase genes may contribute to temephos resistance in the RecR strain as well as other populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21003/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26576515 2015 pai-ana.oa.pdf26576515 2015 pai-ana.oa.pdfapplication/pdf602511https://www.arca.fiocruz.br/bitstream/icict/21003/2/26576515%202015%20pai-ana.oa.pdfa3bdfb10f98627983fa539648d310799MD52TEXT26576515 2015 pai-ana.oa.pdf.txt26576515 2015 pai-ana.oa.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| title |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| spellingShingle |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti Paiva, Marcelo H. S. Aedes Resistência a Inseticidas Locos de Características Quantitativas Aedes drug effects genetics Animals Chromosomes, Insect Insecticide Resistance Insecticides Quantitative Trait Loci Temefos toxicity Aedes Animais Cromossomos de Insetos Resistência a Inseticidas Inseticidas Locos de Características Quantitativas Temefós |
| title_short |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| title_full |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| title_fullStr |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| title_full_unstemmed |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| title_sort |
Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti |
| author |
Paiva, Marcelo H. S. |
| author_facet |
Paiva, Marcelo H. S. Lovin, Diane D. Mori, Akio Melo-Santos, Maria A. V. Severson, David W. Ayres, Constância F. J. |
| author_role |
author |
| author2 |
Lovin, Diane D. Mori, Akio Melo-Santos, Maria A. V. Severson, David W. Ayres, Constância F. J. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Paiva, Marcelo H. S. Lovin, Diane D. Mori, Akio Melo-Santos, Maria A. V. Severson, David W. Ayres, Constância F. J. |
| dc.subject.other.pt_BR.fl_str_mv |
Aedes Resistência a Inseticidas Locos de Características Quantitativas |
| topic |
Aedes Resistência a Inseticidas Locos de Características Quantitativas Aedes drug effects genetics Animals Chromosomes, Insect Insecticide Resistance Insecticides Quantitative Trait Loci Temefos toxicity Aedes Animais Cromossomos de Insetos Resistência a Inseticidas Inseticidas Locos de Características Quantitativas Temefós |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes drug effects genetics Animals Chromosomes, Insect Insecticide Resistance Insecticides Quantitative Trait Loci Temefos toxicity |
| dc.subject.decs.pt_BR.fl_str_mv |
Aedes Animais Cromossomos de Insetos Resistência a Inseticidas Inseticidas Locos de Características Quantitativas Temefós |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2016 |
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2016 |
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2017-09-13T17:43:33Z |
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2017-09-13T17:43:33Z |
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PAIVA, M. H. S. et al. Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti. Genomics, v. 107, n. 1, p. 40–48, jan. 2016. |
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https://www.arca.fiocruz.br/handle/icict/21003 |
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1089-8646 |
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10.1016/j.ygeno.2015.11.004 |
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PAIVA, M. H. S. et al. Identification of a major Quantitative Trait Locus determining resistance to the organophosphate temephos in the dengue vector mosquito Aedes aegypti. Genomics, v. 107, n. 1, p. 40–48, jan. 2016. 1089-8646 10.1016/j.ygeno.2015.11.004 |
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