Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy

Detalhes bibliográficos
Autor(a) principal: Matos, Sheila N. F. Liberato de
Data de Publicação: 2022
Outros Autores: Rocha, Giovanna Ladeia, Carneiro Neto, José Abraão, Oliveira, Cassius J. V. de, Araújo Neto, Cesar, Passos, Lúcia, Oliveira Filho, Jamary, Carvalho, Edgar M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54909
Resumo: Maria Emília Fundação Freire Pedreira de Carvalho. Conselho Nacional de Pesquisa (CNPq) . Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB).
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spelling Matos, Sheila N. F. Liberato deRocha, Giovanna LadeiaCarneiro Neto, José AbraãoOliveira, Cassius J. V. deAraújo Neto, CesarPassos, LúciaOliveira Filho, JamaryCarvalho, Edgar M2022-09-28T12:18:30Z2022-09-28T12:18:30Z2022MATOS, Sheila N. F. Liberato de et al. Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy. Annals of Clinical and Translational Neurology, v. 9, p. 1–9, 2022.2328-9503https://www.arca.fiocruz.br/handle/icict/5490910.1002/acn3.51521Maria Emília Fundação Freire Pedreira de Carvalho. Conselho Nacional de Pesquisa (CNPq) . Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / UniFTC, Salvador, BA, Brasil.Memorial da Imagem/DASA. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Memorial da Imagem/DASA. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Hospital Universitário Professor Edgard Santos. Serviço de Neurologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil.Objective: In the diagnosis of HTLV-1-associated myelopathy (HAM), while magnetic resonance imaging (MRI) is essential to exclude other diseases, its power is limited regarding HAM diagnosis, as only 30% of affected patients present with spinal cord atrophy. Diffusion tensor imaging (DTI) may enable the detection of damage in the white matter microstructure. Here, we quantitatively assess spinal cord damage using DTI and evaluate conventional MRI parameters of the spinal cord in HTLV-1-infected individuals. Methods: This cross-sectional study involved 33 HTLV-1 carriers, 28 patients with definite-HAM, and 11 seronegative healthy subjects (HS). Region-of-interest (ROI)-based fractional anisotropy (FA) and mean diffusivity (MD) measurements were performed in the upper thoracic and lumbar regions of the spinal cord. Thoracic index was defined as 1/ (anteroposterior diameter × transverse diameter) measured at the fifth 5th vertebral level. Receiver operating characteristic (ROC) curve analysis was used to determine optimal cutoff FA, MD, and thoracic index values. Results: Spinal cord atrophy was observed in 15 (53.6%) patients with definite-HAM. The area under the ROC curve in the thoracic spinal cord was 0.824 (95% CI, 0.716–0.932), 0.839 (95% CI: 0.736–0.942), and 0.838 (95% CI: 0.728–0.949) for FA, MD, and the thoracic index, respectively. Lower FA and higher MD values were observed in the definite-HAM group compared to HTLV-1 carriers and HS at the T5 vertebral level (p < 0.01). Interpretation: Complementary to conventional MRI, DTI analysis of the spinal cord and thoracic index determination can offer additional insight that may prove useful in the diagnosis of HAM.engWiley Open AccessSpinal Cord DiseasesHuman T-lymphotropic virus 1MielopatiaHTLV-1Tensor de difusãoMyelopathyHTLV-1Diffusion tensorDoenças da Medula EspinalVírus Linfotrópico T Tipo 1 HumanoImagem de Tensor de DifusãoDiffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54909/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMatos, Sheila N. F Liberato - Diffusion tensor imaging metrics in diagnosis of HTLV‐1‐associated.pdfMatos, Sheila N. F Liberato - Diffusion tensor imaging metrics in diagnosis of HTLV‐1‐associated.pdfapplication/pdf293208https://www.arca.fiocruz.br/bitstream/icict/54909/2/Matos%2c%20Sheila%20N.%20F%20Liberato%20-%20Diffusion%20tensor%20imaging%20metrics%20in%20diagnosis%20of%20HTLV%e2%80%901%e2%80%90associated.pdf276dfebd6c42a9f0dbb38244c886d421MD52icict/549092023-03-15 14:32:53.259oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
title Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
spellingShingle Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
Matos, Sheila N. F. Liberato de
Spinal Cord Diseases
Human T-lymphotropic virus 1
Mielopatia
HTLV-1
Tensor de difusão
Myelopathy
HTLV-1
Diffusion tensor
Doenças da Medula Espinal
Vírus Linfotrópico T Tipo 1 Humano
Imagem de Tensor de Difusão
title_short Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
title_full Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
title_fullStr Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
title_full_unstemmed Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
title_sort Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy
author Matos, Sheila N. F. Liberato de
author_facet Matos, Sheila N. F. Liberato de
Rocha, Giovanna Ladeia
Carneiro Neto, José Abraão
Oliveira, Cassius J. V. de
Araújo Neto, Cesar
Passos, Lúcia
Oliveira Filho, Jamary
Carvalho, Edgar M
author_role author
author2 Rocha, Giovanna Ladeia
Carneiro Neto, José Abraão
Oliveira, Cassius J. V. de
Araújo Neto, Cesar
Passos, Lúcia
Oliveira Filho, Jamary
Carvalho, Edgar M
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Matos, Sheila N. F. Liberato de
Rocha, Giovanna Ladeia
Carneiro Neto, José Abraão
Oliveira, Cassius J. V. de
Araújo Neto, Cesar
Passos, Lúcia
Oliveira Filho, Jamary
Carvalho, Edgar M
dc.subject.mesh.en_US.fl_str_mv Spinal Cord Diseases
Human T-lymphotropic virus 1
topic Spinal Cord Diseases
Human T-lymphotropic virus 1
Mielopatia
HTLV-1
Tensor de difusão
Myelopathy
HTLV-1
Diffusion tensor
Doenças da Medula Espinal
Vírus Linfotrópico T Tipo 1 Humano
Imagem de Tensor de Difusão
dc.subject.other.en_US.fl_str_mv Mielopatia
HTLV-1
Tensor de difusão
dc.subject.en.en_US.fl_str_mv Myelopathy
HTLV-1
Diffusion tensor
dc.subject.decs.en_US.fl_str_mv Doenças da Medula Espinal
Vírus Linfotrópico T Tipo 1 Humano
Imagem de Tensor de Difusão
description Maria Emília Fundação Freire Pedreira de Carvalho. Conselho Nacional de Pesquisa (CNPq) . Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-28T12:18:30Z
dc.date.available.fl_str_mv 2022-09-28T12:18:30Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MATOS, Sheila N. F. Liberato de et al. Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy. Annals of Clinical and Translational Neurology, v. 9, p. 1–9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54909
dc.identifier.issn.en_US.fl_str_mv 2328-9503
dc.identifier.doi.none.fl_str_mv 10.1002/acn3.51521
identifier_str_mv MATOS, Sheila N. F. Liberato de et al. Diffusion tensor imaging metrics in diagnosis of HTLV-1- associated myelopathy. Annals of Clinical and Translational Neurology, v. 9, p. 1–9, 2022.
2328-9503
10.1002/acn3.51521
url https://www.arca.fiocruz.br/handle/icict/54909
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54909/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54909/2/Matos%2c%20Sheila%20N.%20F%20Liberato%20-%20Diffusion%20tensor%20imaging%20metrics%20in%20diagnosis%20of%20HTLV%e2%80%901%e2%80%90associated.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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