Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58482 |
Resumo: | Universidade Federal de Pernambuco. Centro Acadêmico do Agreste. Núcleo de Ciências da Vida. Caruaru, PE, Brasil. |
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Guedes, Diego LinsJusto, Alda MariaBarbosa Júnior, Walter LinsSilva, Elis Dionísio daAquino, Samuel Ricarte deLima Junior, Manoel Sebastiao da CostaMontarroyos, UlissesBezerra, Gilberto Silva NunesVieira, Amanda Virginia BatistaPereira, Valéria Rêgo AlvesMedeiros, Zulma Maria de2023-05-18T16:46:18Z2023-05-18T16:46:18Z2021GUEDES, Diego Lins et al. Asymptomatic Leishmania infection in HIV- positive outpatients on antiretroviral therapy in Pernambuco, Brazil. Plos Neglected Tropical Diseases. [S. l.], p. 1-11. 21 jan. 2021.1935-2735https://www.arca.fiocruz.br/handle/icict/5848210.1371/journal.pntd.00090671935-2735porAgglutination TestsAnti-Retroviral AgentsAsymptomatic InfectionsBrazilCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHIVHIV InfectionsHumansLeishmaniaLeishmaniasisLeishmaniasis, VisceralOutpatientsAsymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Centro Acadêmico do Agreste. Núcleo de Ciências da Vida. Caruaru, PE, Brasil.Instituto Aggeu Magalhães. Fundação Oswaldo Cruz. Departamento de Parasitologia. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Núcleo de Pós-Graduação. Recife, PE, Brasil.Instituto Aggeu Magalhães. Fundação Oswaldo Cruz. Departamento de Imunologia. Recife, PE, Brasil.Universidade Federal do Vale do São Francisco. Hospital Universitário. Petrolina, PE, Brasil.Background: Visceral leishmaniasis (VL) in HIV-positive individuals is a global health problem. HIV-Leishmania coinfection worsens prognosis and mortality risk, and HIV-Leishmania coinfected individuals are more susceptible to VL relapses. Early initiation of antiretroviral therapy can protect against Leishmania infection in individuals living in VL-endemic areas, and regular use of antiretrovirals might prevent VL relapses in these individuals. We conducted a cross-sectional study in Petrolina, Brazil, an VL-endemic area, to estimate the prevalence of asymptomatic Leishmania cases among HIV-positive outpatients. Methods: We invited any HIV-positive patients, aged ≥ 18-years-old, under antiretroviral therapy, and who were asymptomatic for VL. Patients were tested for Leishmania with enzyme-linked immunosorbent assays (ELISA)-rK39, immunochromatographic test (ICT)-rK39, direct agglutination test (DAT), latex agglutination test (KAtex), and conventional polymerase chain reaction (PCR). HIV-Leishmania coinfection was diagnosed when at least one VL test was positive. Results: A total of 483 patients were included. The sample was predominantly composed of single, < 48-years-old, black/pardo, heterosexual males, with fewer than 8 years of schooling. The prevalence of asymptomatic HIV-Leishmania coinfection was 9.11% (44/483). HIV mono-infected and HIV-Leishmania coinfected groups differed statistically significantly in terms of race (p = 0.045), marital status (p = 0.030), and HIV viral load (p = 0.046). Black/pardo patients, married patients, and those with an HIV viral load up to 100,000 copies/ml presented higher odds for HIV-Leishmania coinfection. Conclusions: A considerable number of asymptomatic Leishmania cases were observed among HIV-positive individuals in a VL-endemic area. Given the potential impact on transmission and health costs, as well as the impact on these coinfected individuals, studies of asymptomatic Leishmania carriers can be useful for guiding public health policies in VL-endemic areas aiming to control and eliminate the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAsymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil.pdfAsymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil.pdfapplication/pdf539495https://www.arca.fiocruz.br/bitstream/icict/58482/2/Asymptomatic%20Leishmania%20infection%20in%20HIV-positive%20outpatients%20on%20antiretroviral%20therapy%20in%20Pernambuco%2c%20Brazil.pdf73f3cfe6f41f80ee06ba602b3e36be8fMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58482/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584822023-05-18 13:46:19.997oai:www.arca.fiocruz.br:icict/58482Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-18T16:46:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| title |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| spellingShingle |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil Guedes, Diego Lins Agglutination Tests Anti-Retroviral Agents Asymptomatic Infections Brazil Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay HIV HIV Infections Humans Leishmania Leishmaniasis Leishmaniasis, Visceral Outpatients |
| title_short |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| title_full |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| title_fullStr |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| title_full_unstemmed |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| title_sort |
Asymptomatic Leishmania infection in HIV-positive outpatients on antiretroviral therapy in Pernambuco, Brazil |
| author |
Guedes, Diego Lins |
| author_facet |
Guedes, Diego Lins Justo, Alda Maria Barbosa Júnior, Walter Lins Silva, Elis Dionísio da Aquino, Samuel Ricarte de Lima Junior, Manoel Sebastiao da Costa Montarroyos, Ulisses Bezerra, Gilberto Silva Nunes Vieira, Amanda Virginia Batista Pereira, Valéria Rêgo Alves Medeiros, Zulma Maria de |
| author_role |
author |
| author2 |
Justo, Alda Maria Barbosa Júnior, Walter Lins Silva, Elis Dionísio da Aquino, Samuel Ricarte de Lima Junior, Manoel Sebastiao da Costa Montarroyos, Ulisses Bezerra, Gilberto Silva Nunes Vieira, Amanda Virginia Batista Pereira, Valéria Rêgo Alves Medeiros, Zulma Maria de |
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author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Guedes, Diego Lins Justo, Alda Maria Barbosa Júnior, Walter Lins Silva, Elis Dionísio da Aquino, Samuel Ricarte de Lima Junior, Manoel Sebastiao da Costa Montarroyos, Ulisses Bezerra, Gilberto Silva Nunes Vieira, Amanda Virginia Batista Pereira, Valéria Rêgo Alves Medeiros, Zulma Maria de |
| dc.subject.mesh.en_US.fl_str_mv |
Agglutination Tests Anti-Retroviral Agents Asymptomatic Infections Brazil Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay HIV HIV Infections Humans Leishmania Leishmaniasis Leishmaniasis, Visceral Outpatients |
| topic |
Agglutination Tests Anti-Retroviral Agents Asymptomatic Infections Brazil Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay HIV HIV Infections Humans Leishmania Leishmaniasis Leishmaniasis, Visceral Outpatients |
| description |
Universidade Federal de Pernambuco. Centro Acadêmico do Agreste. Núcleo de Ciências da Vida. Caruaru, PE, Brasil. |
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2021 |
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2021 |
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2023-05-18T16:46:18Z |
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2023-05-18T16:46:18Z |
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GUEDES, Diego Lins et al. Asymptomatic Leishmania infection in HIV- positive outpatients on antiretroviral therapy in Pernambuco, Brazil. Plos Neglected Tropical Diseases. [S. l.], p. 1-11. 21 jan. 2021. |
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10.1371/journal.pntd.0009067 |
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1935-2735 |
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GUEDES, Diego Lins et al. Asymptomatic Leishmania infection in HIV- positive outpatients on antiretroviral therapy in Pernambuco, Brazil. Plos Neglected Tropical Diseases. [S. l.], p. 1-11. 21 jan. 2021. 1935-2735 10.1371/journal.pntd.0009067 |
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