Spontaneous Abortion and Chikungunya Infection: Pathological Findings

Detalhes bibliográficos
Autor(a) principal: Salomão, Natália
Data de Publicação: 2021
Outros Autores: Brendolin, Michelle, Rabelo, Kíssila, Wakimoto, Mayumi, Filippis, Ana Maria de, Santos, Flavia dos, Moreira, Maria Elizabeth, Basílio-de-Oliveira, Carlos Alberto, Avvad-Portari, Elyzabeth, Paes, Marciano, Brasil, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47370
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Médica Interdisciplinar. Rio de Janeiro, RJ, Brasil.
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spelling Salomão, NatáliaBrendolin, MichelleRabelo, KíssilaWakimoto, MayumiFilippis, Ana Maria deSantos, Flavia dosMoreira, Maria ElizabethBasílio-de-Oliveira, Carlos AlbertoAvvad-Portari, ElyzabethPaes, MarcianoBrasil, Patrícia2021-05-25T20:22:20Z2021-05-25T20:22:20Z2021SALOMÃO, Natália et al. Spontaneous Abortion and Chikungunya Infection: Pathological Findings. Viruses, v. 13, n. 4, p. 1-11, Mar. 2021.1999-4915https://www.arca.fiocruz.br/handle/icict/4737010.3390/v13040554engMDPISpontaneous Abortion and Chikungunya Infection: Pathological Findingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Médica Interdisciplinar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, Criança e Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Médica Interdisciplinar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Intrauterine transmission of the Chikungunya virus (CHIKV) during early pregnancy has rarely been reported, although vertical transmission has been observed in newborns. Here, we report four cases of spontaneous abortion in women who became infected with CHIKV between the 11th and 17th weeks of pregnancy. Laboratorial confirmation of the infection was conducted by RT-PCR on a urine sample for one case, and the other three were by detection of IgM anti-CHIKV antibodies. Hematoxylin and eosin (H&E) staining and an electron microscopy assay allowed us to find histopathological, such as inflammatory infiltrate in the decidua and chorionic villi, as well as areas of calcification, edema and the deposition of fibrinoid material, and ultrastructural changes, such as mitochondria with fewer cristae and ruptured membranes, endoplasmic reticulum with dilated cisterns, dispersed chromatin in the nuclei and the presence of an apoptotic body in case 1. In addition, by immunohistochemistry (IHC), we found a positivity for the anti-CHIKV antibody in cells of the endometrial glands, decidual cells, syncytiotrophoblasts, cytotrophoblasts, Hofbauer cells and decidual macrophages. Electron microscopy also helped in identifying virus-like particles in the aborted material with a diameter of 40-50 nm, which was consistent with the size of CHIKV particles in the literature. Our findings in this study suggest early maternal fetal transmission, adding more evidence on the role of CHIKV in fetal death.ChikungunyaPCR confirmed infectionPathological findingsSpontaneous abortioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/47370/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALSpontaneous_Patricia_Brasil_etal_INI_2021.pdfSpontaneous_Patricia_Brasil_etal_INI_2021.pdfapplication/pdf2340865https://www.arca.fiocruz.br/bitstream/icict/47370/2/Spontaneous_Patricia_Brasil_etal_INI_2021.pdfd6d160e854644e10c5546dfd374f9e60MD52TEXTSpontaneous_Patricia_Brasil_etal_INI_2021.pdf.txtSpontaneous_Patricia_Brasil_etal_INI_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Spontaneous Abortion and Chikungunya Infection: Pathological Findings
title Spontaneous Abortion and Chikungunya Infection: Pathological Findings
spellingShingle Spontaneous Abortion and Chikungunya Infection: Pathological Findings
Salomão, Natália
Chikungunya
PCR confirmed infection
Pathological findings
Spontaneous abortion
title_short Spontaneous Abortion and Chikungunya Infection: Pathological Findings
title_full Spontaneous Abortion and Chikungunya Infection: Pathological Findings
title_fullStr Spontaneous Abortion and Chikungunya Infection: Pathological Findings
title_full_unstemmed Spontaneous Abortion and Chikungunya Infection: Pathological Findings
title_sort Spontaneous Abortion and Chikungunya Infection: Pathological Findings
author Salomão, Natália
author_facet Salomão, Natália
Brendolin, Michelle
Rabelo, Kíssila
Wakimoto, Mayumi
Filippis, Ana Maria de
Santos, Flavia dos
Moreira, Maria Elizabeth
Basílio-de-Oliveira, Carlos Alberto
Avvad-Portari, Elyzabeth
Paes, Marciano
Brasil, Patrícia
author_role author
author2 Brendolin, Michelle
Rabelo, Kíssila
Wakimoto, Mayumi
Filippis, Ana Maria de
Santos, Flavia dos
Moreira, Maria Elizabeth
Basílio-de-Oliveira, Carlos Alberto
Avvad-Portari, Elyzabeth
Paes, Marciano
Brasil, Patrícia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salomão, Natália
Brendolin, Michelle
Rabelo, Kíssila
Wakimoto, Mayumi
Filippis, Ana Maria de
Santos, Flavia dos
Moreira, Maria Elizabeth
Basílio-de-Oliveira, Carlos Alberto
Avvad-Portari, Elyzabeth
Paes, Marciano
Brasil, Patrícia
dc.subject.en.pt_BR.fl_str_mv Chikungunya
PCR confirmed infection
Pathological findings
Spontaneous abortion
topic Chikungunya
PCR confirmed infection
Pathological findings
Spontaneous abortion
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Médica Interdisciplinar. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-05-25T20:22:20Z
dc.date.available.fl_str_mv 2021-05-25T20:22:20Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALOMÃO, Natália et al. Spontaneous Abortion and Chikungunya Infection: Pathological Findings. Viruses, v. 13, n. 4, p. 1-11, Mar. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47370
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v13040554
identifier_str_mv SALOMÃO, Natália et al. Spontaneous Abortion and Chikungunya Infection: Pathological Findings. Viruses, v. 13, n. 4, p. 1-11, Mar. 2021.
1999-4915
10.3390/v13040554
url https://www.arca.fiocruz.br/handle/icict/47370
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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