Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil

Detalhes bibliográficos
Autor(a) principal: Moura, Ana Rafaela Silva Simões
Data de Publicação: 2018
Outros Autores: Kretz, Cécilia Batmalle, Ferreira, Ítalo Eustáquio, Nunes, Amélia Maria Pithon Borges, Filippis, Ivano de, Moraes, José Cássio de, Reis, Mitermayer Galvão dos, McBride, Alan John Alexander, Wang, Xin, Campos, Leila Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25978
Resumo: Ministério da Saúde, Brazil (grant number TC335/2013), and Fundação de Amparo à Pesquisa do Estado da Bahia (grant number SUS 007/2014).
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spelling Moura, Ana Rafaela Silva SimõesKretz, Cécilia BatmalleFerreira, Ítalo EustáquioNunes, Amélia Maria Pithon BorgesFilippis, Ivano deMoraes, José Cássio deReis, Mitermayer Galvão dosMcBride, Alan John AlexanderWang, XinCampos, Leila Carvalho2018-04-20T13:27:05Z2018-04-20T13:27:05Z2018MOURA, A. R. S. S. et al. Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil. International Journal of Medical Microbiology, 2018.1438-4221https://www.arca.fiocruz.br/handle/icict/2597810.1016/j.ijmm.2018.03.007Ministério da Saúde, Brazil (grant number TC335/2013), and Fundação de Amparo à Pesquisa do Estado da Bahia (grant number SUS 007/2014).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilCenters for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta GA, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, BrasilSanta Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal de Pelotas. Centro de Desenvolvimento Tecnológico. Núcleo de Biotecnologia. Pelotas, RS, BrasilCenters for Disease Control and Prevention. Meningitis and Vaccine Preventable Diseases Branch. Division of Bacterial Diseases. Atlanta GA, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilNeisseria lactamica is a nonpathogenic commensal bacterium that is potentially associated with the development of natural immunity against N. meningitidis. However, the genetic variation present in natural populations of N. lactamica has not been fully investigated. To better understand its epidemiology and genetic variation, we studied N. lactamica carriage in 1200 students aged 11-19 years old in Salvador, Brazil. The carriage prevalence was 4.5% (54/1200), with no statistical difference among sex and age, although we observed a trend towards higher carriage prevalence among 11-year-old individuals. Whole genome sequence analysis revealed a high genetic diversity among the isolates, with the presence of 32 different STs, 28 (87.5%) of which were new. A total of 21/50 (42%) isolates belonged to three different clonal complexes. While none of the isolates contained nadA or fHpb alleles, we detected 21 FetA variants, 20 NhbA variants and two variants of PorB. The data provide detailed information on circulating N. lactamica isolates in adolescents in Brazil and are complementary to studies in other countries.engElsevierNeisseria lactamicaNeisseria meningitidisTransporte orofaríngeoVacinasNeisseria lactamicaNeisseria meningitidisOropharyngeal carriageVaccinesEpidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25978/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMoura A Epidemiology and molecular....pdfMoura A Epidemiology and 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dc.title.pt_BR.fl_str_mv Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
title Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
spellingShingle Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
Moura, Ana Rafaela Silva Simões
Neisseria lactamica
Neisseria meningitidis
Transporte orofaríngeo
Vacinas
Neisseria lactamica
Neisseria meningitidis
Oropharyngeal carriage
Vaccines
title_short Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
title_full Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
title_fullStr Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
title_full_unstemmed Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
title_sort Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil
author Moura, Ana Rafaela Silva Simões
author_facet Moura, Ana Rafaela Silva Simões
Kretz, Cécilia Batmalle
Ferreira, Ítalo Eustáquio
Nunes, Amélia Maria Pithon Borges
Filippis, Ivano de
Moraes, José Cássio de
Reis, Mitermayer Galvão dos
McBride, Alan John Alexander
Wang, Xin
Campos, Leila Carvalho
author_role author
author2 Kretz, Cécilia Batmalle
Ferreira, Ítalo Eustáquio
Nunes, Amélia Maria Pithon Borges
Filippis, Ivano de
Moraes, José Cássio de
Reis, Mitermayer Galvão dos
McBride, Alan John Alexander
Wang, Xin
Campos, Leila Carvalho
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Ana Rafaela Silva Simões
Kretz, Cécilia Batmalle
Ferreira, Ítalo Eustáquio
Nunes, Amélia Maria Pithon Borges
Filippis, Ivano de
Moraes, José Cássio de
Reis, Mitermayer Galvão dos
McBride, Alan John Alexander
Wang, Xin
Campos, Leila Carvalho
dc.subject.other.pt_BR.fl_str_mv Neisseria lactamica
Neisseria meningitidis
Transporte orofaríngeo
Vacinas
topic Neisseria lactamica
Neisseria meningitidis
Transporte orofaríngeo
Vacinas
Neisseria lactamica
Neisseria meningitidis
Oropharyngeal carriage
Vaccines
dc.subject.en.pt_BR.fl_str_mv Neisseria lactamica
Neisseria meningitidis
Oropharyngeal carriage
Vaccines
description Ministério da Saúde, Brazil (grant number TC335/2013), and Fundação de Amparo à Pesquisa do Estado da Bahia (grant number SUS 007/2014).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-04-20T13:27:05Z
dc.date.available.fl_str_mv 2018-04-20T13:27:05Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOURA, A. R. S. S. et al. Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil. International Journal of Medical Microbiology, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25978
dc.identifier.issn.pt_BR.fl_str_mv 1438-4221
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijmm.2018.03.007
identifier_str_mv MOURA, A. R. S. S. et al. Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil. International Journal of Medical Microbiology, 2018.
1438-4221
10.1016/j.ijmm.2018.03.007
url https://www.arca.fiocruz.br/handle/icict/25978
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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