The A-Z of Zika drug discovery
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27785 |
Resumo: | Universidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil. |
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Mottin, MelinaBorba, Joyce V. V. B.Braga, Rodolpho C.Torres, Pedro H. M.Martini, Matheus C.Módena, Jose Luiz ProencaJudice, Carla C.Costa, Fabio T. M.Ekins, SeanPerryman, Alexander L.Andrade, Carolina Horta2018-08-02T12:47:52Z2018-08-02T12:47:52Z2018MOTTIN, Melina; et al. The A–Z of Zika drug discovery. Drug Discovery Today, v.00, n.00, 15p, June 2018.1359-6446https://www.arca.fiocruz.br/handle/icict/2778510.1016/j.drudis.2018.06.014engElsevierZika VirusMedicamentosZika VirusDrugs discoveryThe A-Z of Zika drug discoveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil.Universidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil.Universidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / University of Cambridge. Department of Biochemistry. London, UK.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Collaborations Pharmaceuticals, Inc. Raleigh, NC 27606, USA.Rutgers University–New Jersey Medical School. Department of Pharmacology, Physiology and Neuroscience. Newark, NJ, USA.Universidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil / Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A-Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27785/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPHM_torres_etal_IOC_2018.pdfPHM_torres_etal_IOC_2018.pdfapplication/pdf2136278https://www.arca.fiocruz.br/bitstream/icict/27785/2/PHM_torres_etal_IOC_2018.pdf0c319e8dd6057f423b6a61ea6b50d413MD52TEXTPHM_torres_etal_IOC_2018.pdf.txtPHM_torres_etal_IOC_2018.pdf.txtExtracted texttext/plain96921https://www.arca.fiocruz.br/bitstream/icict/27785/3/PHM_torres_etal_IOC_2018.pdf.txtfe4bf5bee9bee1fa3da1d548d69c65cdMD53icict/277852018-08-15 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| dc.title.pt_BR.fl_str_mv |
The A-Z of Zika drug discovery |
| title |
The A-Z of Zika drug discovery |
| spellingShingle |
The A-Z of Zika drug discovery Mottin, Melina Zika Virus Medicamentos Zika Virus Drugs discovery |
| title_short |
The A-Z of Zika drug discovery |
| title_full |
The A-Z of Zika drug discovery |
| title_fullStr |
The A-Z of Zika drug discovery |
| title_full_unstemmed |
The A-Z of Zika drug discovery |
| title_sort |
The A-Z of Zika drug discovery |
| author |
Mottin, Melina |
| author_facet |
Mottin, Melina Borba, Joyce V. V. B. Braga, Rodolpho C. Torres, Pedro H. M. Martini, Matheus C. Módena, Jose Luiz Proenca Judice, Carla C. Costa, Fabio T. M. Ekins, Sean Perryman, Alexander L. Andrade, Carolina Horta |
| author_role |
author |
| author2 |
Borba, Joyce V. V. B. Braga, Rodolpho C. Torres, Pedro H. M. Martini, Matheus C. Módena, Jose Luiz Proenca Judice, Carla C. Costa, Fabio T. M. Ekins, Sean Perryman, Alexander L. Andrade, Carolina Horta |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mottin, Melina Borba, Joyce V. V. B. Braga, Rodolpho C. Torres, Pedro H. M. Martini, Matheus C. Módena, Jose Luiz Proenca Judice, Carla C. Costa, Fabio T. M. Ekins, Sean Perryman, Alexander L. Andrade, Carolina Horta |
| dc.subject.other.pt_BR.fl_str_mv |
Zika Virus Medicamentos |
| topic |
Zika Virus Medicamentos Zika Virus Drugs discovery |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Virus Drugs discovery |
| description |
Universidade Federal de Goias. Faculdade de Farmácia. Laboratório de Planejamento de Fármacos e Modelagem Molecular. Goiânia, GO, Brasil. |
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2018 |
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2018-08-02T12:47:52Z |
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2018 |
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MOTTIN, Melina; et al. The A–Z of Zika drug discovery. Drug Discovery Today, v.00, n.00, 15p, June 2018. |
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https://www.arca.fiocruz.br/handle/icict/27785 |
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1359-6446 |
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10.1016/j.drudis.2018.06.014 |
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MOTTIN, Melina; et al. The A–Z of Zika drug discovery. Drug Discovery Today, v.00, n.00, 15p, June 2018. 1359-6446 10.1016/j.drudis.2018.06.014 |
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