Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy

Detalhes bibliográficos
Autor(a) principal: Amor, Ana Lúcia Moreno
Data de Publicação: 2014
Outros Autores: Santos, Leonardo Nascimento, Galvão, Alana Alcântara, Belitardo, Emília Maria Medeiros de Andrade, Silva, Eduardo Santos, Neves, Neuza Maria Alcântara, Pontes-de-Carvalho, Lain Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.2217/imt.14.89
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15564
Resumo: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Campus do Governo. Santo Antônio de Jesus, BA, Brasil
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spelling Amor, Ana Lúcia MorenoSantos, Leonardo NascimentoGalvão, Alana AlcântaraBelitardo, Emília Maria Medeiros de AndradeSilva, Eduardo SantosNeves, Neuza Maria AlcântaraPontes-de-Carvalho, Lain Carlos2016-08-31T17:41:01Z2016-08-31T17:41:01Z2014AMOR, A. L. M. et al. Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy. Immunotherapy, v. 6, n.12, p. 1255-1264, 2014.1750-743Xhttps://www.arca.fiocruz.br/handle/icict/1556410.2217/imt.14.89engFuture MedicineCandidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Campus do Governo. Santo Antônio de Jesus, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BAUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BAUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BAUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BAUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThis study's objective was to investigate whether candidin or trichophytin elicit recall immune responses that could potentially inhibit a Th2 response. MATERIALS & METHODS: Peripheral blood mononuclear cells from nine allergic and seven nonallergic individuals were cultivated in vitro in the presence or absence of these fungal extracts. RESULTS: Trichophytin or candidin, or both, stimulated the production of regulatory cytokines (TGF-β and/or IL-10), accompanied or not by stimulation of production of cytokines associated with the Th1 response (TNF-α, IL-12 and IFN-γ), but without stimulation of Th2 cytokines (IL-5 and IL-13) and IL-17, by peripheral blood mononuclear cells of most allergic and nonallergic individuals. CONCLUSION: These results indicate that these fungal extracts could be used as adjuvants in personalized therapeutic vaccines in a fair proportion of individuals. In addition, they justify the carrying out of investigations aimed at identifying molecules in these extracts that might exclusively induce Treg and/or Th1 immune responses.CandidinCytokineImmune responseImmunotherapyTrichophytininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15564/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAmor ALM Candidin and trichophytin....pdfAmor ALM Candidin and trichophytin....pdfapplication/pdf693738https://www.arca.fiocruz.br/bitstream/icict/15564/2/Amor%20ALM%20Candidin%20and%20trichophytin....pdf73222b342a64a31b9e644e05d57ab0e6MD52TEXTAmor ALM Candidin and trichophytin....pdf.txtAmor ALM Candidin and trichophytin....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
title Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
spellingShingle Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
Amor, Ana Lúcia Moreno
Candidin
Cytokine
Immune response
Immunotherapy
Trichophytin
title_short Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
title_full Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
title_fullStr Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
title_full_unstemmed Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
title_sort Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy
author Amor, Ana Lúcia Moreno
author_facet Amor, Ana Lúcia Moreno
Santos, Leonardo Nascimento
Galvão, Alana Alcântara
Belitardo, Emília Maria Medeiros de Andrade
Silva, Eduardo Santos
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
author_role author
author2 Santos, Leonardo Nascimento
Galvão, Alana Alcântara
Belitardo, Emília Maria Medeiros de Andrade
Silva, Eduardo Santos
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amor, Ana Lúcia Moreno
Santos, Leonardo Nascimento
Galvão, Alana Alcântara
Belitardo, Emília Maria Medeiros de Andrade
Silva, Eduardo Santos
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
dc.subject.en.pt_BR.fl_str_mv Candidin
Cytokine
Immune response
Immunotherapy
Trichophytin
topic Candidin
Cytokine
Immune response
Immunotherapy
Trichophytin
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biointeração. Laboratório de Alergia e Acarologia. Salvador, BA / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Campus do Governo. Santo Antônio de Jesus, BA, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-08-31T17:41:01Z
dc.date.available.fl_str_mv 2016-08-31T17:41:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv AMOR, A. L. M. et al. Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy. Immunotherapy, v. 6, n.12, p. 1255-1264, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15564
dc.identifier.issn.pt_BR.fl_str_mv 1750-743X
dc.identifier.doi.none.fl_str_mv 10.2217/imt.14.89
identifier_str_mv AMOR, A. L. M. et al. Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy. Immunotherapy, v. 6, n.12, p. 1255-1264, 2014.
1750-743X
10.2217/imt.14.89
url https://www.arca.fiocruz.br/handle/icict/15564
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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