Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18728 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. |
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Cunha Junior, Edézio FerreiraAndrade Neto, Valter VianaLima, Marta LopesSilva, Thais Alves da CostaGalisteo Junior, Andres J.Abengózar, Maria A.Barbas, CoralRivas, LuisAmaral, Elmo Eduardo AlmeidaTempone, Andre GustavoSantos, Eduardo Caio Torres2017-05-04T12:14:58Z2017-05-04T12:14:58Z2017CUNHA JUNIOR, Edézio Ferreira; et al. Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. PLoS Negl Trop Dis, v.11, n.1, e0005281, 11p, Jan. 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/1872810.1371/journal.pntd.00052811935-2735engPublic Library of ScienceLieshmanioseCyclobenzaprineTerapêuticaCyclobenzaprinetherapeuticvisceral leishmaniasisCyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil.Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain.Universidad CEU San Pablo. Faculty of Pharmacy. Center for Metabolomics and Bioanalysis (CEMBIO. Madrid, Spain.Centro de Investigaciones BioloÂgicas (CSIC). Unidad Asociada Interacciones, Metabolismo y Bioanálisis CSIC-CEU. Madrid, Spain.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.Instituto Adolfo Lutz. Centro de Parasitologia e Micologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring. This paper describes the effect of CBP in experimental visceral leishmaniasis, its inhibitory effect in trypanothione reductase and the potential immunomodulatory activity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18728/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALedesio_cunhajr_etal_IOC_2017.pdfedesio_cunhajr_etal_IOC_2017.pdfapplication/pdf1518221https://www.arca.fiocruz.br/bitstream/icict/18728/2/edesio_cunhajr_etal_IOC_2017.pdf6be150919adf4e381a7886f6406acc7bMD52TEXTedesio_cunhajr_etal_IOC_2017.pdf.txtedesio_cunhajr_etal_IOC_2017.pdf.txtExtracted texttext/plain29609https://www.arca.fiocruz.br/bitstream/icict/18728/3/edesio_cunhajr_etal_IOC_2017.pdf.txt3e8ae2e96cfd7f03e4b03b7e56e1f3a7MD53icict/187282023-09-14 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| dc.title.pt_BR.fl_str_mv |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| title |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| spellingShingle |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice Cunha Junior, Edézio Ferreira Lieshmaniose Cyclobenzaprine Terapêutica Cyclobenzaprine therapeutic visceral leishmaniasis |
| title_short |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| title_full |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| title_fullStr |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| title_full_unstemmed |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| title_sort |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice |
| author |
Cunha Junior, Edézio Ferreira |
| author_facet |
Cunha Junior, Edézio Ferreira Andrade Neto, Valter Viana Lima, Marta Lopes Silva, Thais Alves da Costa Galisteo Junior, Andres J. Abengózar, Maria A. Barbas, Coral Rivas, Luis Amaral, Elmo Eduardo Almeida Tempone, Andre Gustavo Santos, Eduardo Caio Torres |
| author_role |
author |
| author2 |
Andrade Neto, Valter Viana Lima, Marta Lopes Silva, Thais Alves da Costa Galisteo Junior, Andres J. Abengózar, Maria A. Barbas, Coral Rivas, Luis Amaral, Elmo Eduardo Almeida Tempone, Andre Gustavo Santos, Eduardo Caio Torres |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cunha Junior, Edézio Ferreira Andrade Neto, Valter Viana Lima, Marta Lopes Silva, Thais Alves da Costa Galisteo Junior, Andres J. Abengózar, Maria A. Barbas, Coral Rivas, Luis Amaral, Elmo Eduardo Almeida Tempone, Andre Gustavo Santos, Eduardo Caio Torres |
| dc.subject.other.pt_BR.fl_str_mv |
Lieshmaniose Cyclobenzaprine Terapêutica |
| topic |
Lieshmaniose Cyclobenzaprine Terapêutica Cyclobenzaprine therapeutic visceral leishmaniasis |
| dc.subject.en.pt_BR.fl_str_mv |
Cyclobenzaprine therapeutic visceral leishmaniasis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. |
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2017 |
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2017-05-04T12:14:58Z |
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2017-05-04T12:14:58Z |
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2017 |
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CUNHA JUNIOR, Edézio Ferreira; et al. Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. PLoS Negl Trop Dis, v.11, n.1, e0005281, 11p, Jan. 2017. |
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https://www.arca.fiocruz.br/handle/icict/18728 |
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1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0005281 |
| dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
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CUNHA JUNIOR, Edézio Ferreira; et al. Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. PLoS Negl Trop Dis, v.11, n.1, e0005281, 11p, Jan. 2017. 1935-2727 10.1371/journal.pntd.0005281 1935-2735 |
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